Angiotensin Type 2 Receptors: Painful, or Not?

Emerging role of angiotensin AT2 receptor in anti-inflammation: an update

(2020) Sanket N. Patel et al.   CURRENT PHARMACEUTICAL DESIGN

AT2R agonist NP‐6A4 mitigates aortic stiffness and proteolytic activity in mouse model of aneurysm

(2020) Neekun Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

The Renin-Angiotensin System: Going Beyond the Classical Paradigms

(2019) Robson A. Souza Santos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Anti‐fibrotic mechanisms of angiotensin AT 2 ‐receptor stimulation

(2019) Colin Sumners et al.   Acta Physiologica

Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?

(2019) Simona Giorgi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unique Characteristics of the Dorsal Root Ganglion as a Target for Neuromodulation

(2019) Michael F Esposito et al.   PAIN MEDICINE

Identification of protein phosphatase involvement in the AT 2 receptor-induced activation of endothelial nitric oxide synthase

(2018) A. Augusto Peluso et al.   CLINICAL SCIENCE

Neuroprotection via AT 2 receptor agonists in ischemic stroke

(2018) Douglas M. Bennion et al.   CLINICAL SCIENCE

The Effect of a Non-peptide Angiotensin II type 2 receptor Agonist, Compound 21, on Aortic Aneurysm Growth in a Mouse Model of Marfan Syndrome

(2018) Peter Verbrugghe et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

(2018) Robson Augusto Souza Santos et al.   PHYSIOLOGICAL REVIEWS

Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels

(2018) Cristina Carrasco et al.   Frontiers in Physiology

AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47phox Phosphorylation by PP2A

(2018) Shahnawaz Ali Bhat et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effect of angiotensin II type 2 receptor stimulation in vincristine-induced mechanical allodynia

(2018) Flavien Bessaguet et al.   PAIN

Macrophage angiotensin II type 2 receptor triggers neuropathic pain

(2018) Andrew J. Shepherd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Specific Protective Signaling Induced by the Novel AT2R-Agonist NP-6A4 on Human Endothelial and Smooth Muscle Cells

(2018) Ryan Toedebusch et al.   Frontiers in Pharmacology

Attenuation of Unevoked Mechanical and Cold Pain Hypersensitivities Associated With Experimental Neuropathy in Mice by Angiotensin II Type-2 Receptor Antagonism

(2018) Andrew J. Shepherd et al.   ANESTHESIA AND ANALGESIA

Current understanding of the mixed pain concept: a brief narrative review

(2018) Rainer Freynhagen et al.   CURRENT MEDICAL RESEARCH AND OPINION

Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain

(2017) Temugin Berta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Advances in understanding nociception and neuropathic pain

(2017) Ewan St. John Smith   JOURNAL OF NEUROLOGY

Structural basis for selectivity and diversity in angiotensin II receptors

(2017) Haitao Zhang et al.   NATURE

Candesartan prevents resiniferatoxin-induced sensory small-fiber neuropathy in mice by promoting angiotensin II-mediated AT2 receptor stimulation

(2017) Flavien Bessaguet et al.   NEUROPHARMACOLOGY

Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months

(2017) Timothy R. Deer et al.   PAIN

AT2 receptors in cardiovascular and renal diseases

(2017) Elena Kaschina et al.   PHARMACOLOGICAL RESEARCH

Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor

(2017) U. Muscha Steckelings et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

(2017) Francesco De Logu et al.   Nature Communications

Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) Receptor Antagonist

(2017) Nemat Khan et al.   Frontiers in Molecular Neuroscience

Anti-fibrotic Potential of AT2 Receptor Agonists

(2017) Yan Wang et al.   Frontiers in Pharmacology

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Cardiovascular disease progression in female Zucker Diabetic Fatty rats occurs via unique mechanisms compared to males

(2017) Kelly Lum-Naihe et al.   Scientific Reports

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

(2016) Gabriela Trevisan et al.   BRAIN

Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

(2016) B. S. M. Chow et al.   CLINICAL SCIENCE

Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice

(2016) Annette D. de Kloet et al.   ENDOCRINOLOGY

Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1A1166Cand AGTR2G1675Agene polymorphisms

(2016) Marcin Cwynar et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain

(2016) Maree T. Smith et al.   PAIN

Neuropathic pain

(2016) Nanna B. Finnerup et al.   PAIN

Nitroxidative Signaling Mechanisms in Pathological Pain

(2016) Peter M. Grace et al.   TRENDS IN NEUROSCIENCES

Suppression of Resting Metabolism by the Angiotensin AT 2 Receptor

(2016) Nicole K. Littlejohn et al.   Cell Reports

Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders

(2015) Ludovit Paulis et al.   DRUGS

TRPA1 as a drug target—promise and challenges

(2015) Jun Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice

(2015) Wataru Nemoto et al.   NEUROPHARMACOLOGY

Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson's disease in CATH.a cells

(2015) Jie Lu et al.   NEUROTOXICOLOGY AND TERATOLOGY

ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration

(2015) Paula Santabárbara-Ruiz et al.   PLoS Genetics

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

AT 2 Receptor Activation Induces Natriuresis and Lowers Blood Pressure

(2014) Brandon A. Kemp et al.   CIRCULATION RESEARCH

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial

(2014) Andrew S C Rice et al.   LANCET

Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling

(2013) Liang Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Protective arms of the renin-angiotensin-system in neurological disease

(2013) Colin Sumners et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Angiotensin II Receptor Type 2 Activation Is Required for Cutaneous Sensory Hyperinnervation and Hypersensitivity in a Rat Hind Paw Model of Inflammatory Pain

(2013) Anuradha Chakrabarty et al.   JOURNAL OF PAIN

Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats

(2013) Maree T. Smith et al.   PAIN MEDICINE

Analgesic Efficacy and Mode of Action of a Selective Small Molecule Angiotensin II Type 2 Receptor Antagonist in a Rat Model of Prostate Cancer-Induced Bone Pain

(2013) Arjun Muralidharan et al.   PAIN MEDICINE

Species differences and molecular determinant of TRPA1 cold sensitivity

(2013) Jun Chen et al.   Nature Communications

Roles of Brain Angiotensin II in Cognitive Function and Dementia

(2012) Masaki Mogi et al.   International Journal of Hypertension

The Angiotensin II Type 2 Receptor in Brain Functions: An Update

(2012) Marie-Odile Guimond et al.   International Journal of Hypertension

The renin–angiotensin system in the breast and breast cancer

(2011) Gavin P Vinson et al.   ENDOCRINE-RELATED CANCER

Sex-Specific Influence of Angiotensin Type 2 Receptor Stimulation on Renal Function

(2011) Lucinda M. Hilliard et al.   HYPERTENSION

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

The angiotensin AT2 receptor in inflammation

(2010) F. Rompe et al.   DRUG NEWS & PERSPECTIVES

Identification of Noncytotoxic and IL-10-Producing CD8+AT2R+ T Cell Population in Response to Ischemic Heart Injury

(2010) C. Curato et al.   JOURNAL OF IMMUNOLOGY

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception

(2010) Kyeongjin Kang et al.   NATURE

The angiotensin II type 2 receptor in cardiovascular disease

(2009) Catherine A Lemarié et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Angiotensin II–Triggered p44/42 Mitogen-Activated Protein Kinase Mediates Sympathetic Excitation in Heart Failure Rats

(2008) Shun-Guang Wei et al.   HYPERTENSION

Enhanced Angiotensin II Type 2 Receptor Mechanisms Mediate Decreases in Arterial Pressure Attributable to Chronic Low-Dose Angiotensin II in Female Rats

(2008) Amanda K. Sampson et al.   HYPERTENSION

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

AT2 receptors: Functional relevance in cardiovascular disease

(2008) Emma S. Jones et al.   PHARMACOLOGY & THERAPEUTICS