Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders

Compound 21, a selective agonist of angiotensin AT2receptors, prevents endothelial inflammation and leukocyte adhesionin vitroandin vivo

(2015) Amanda K Sampson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice

(2015) Verónica Valero-Esquitino et al.   CLINICAL SCIENCE

Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison

(2015) Daniel Villela et al.   CLINICAL SCIENCE

Hypotensive and sympathoinhibitory responses to selective central AT2receptor stimulation in spontaneously hypertensive rats

(2015) Sofie Brouwers et al.   CLINICAL SCIENCE

New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon?

(2015) Ludovit Paulis et al.   CURRENT HYPERTENSION REPORTS

AT2R Agonist, Compound 21, Is Reno-Protective Against Type 1 Diabetic Nephropathy

(2015) C. Koulis et al.   HYPERTENSION

Stimulation of the Angiotensin II AT2 Receptor is Anti-inflammatory in Human Lipopolysaccharide-Activated Monocytic Cells

(2015) Mario Menk et al.   INFLAMMATION

A Nonpeptide Angiotensin II Type 2 Receptor Agonist Prevents Renal Inflammation in Early Diabetes

(2015) Luis C. Matavelli et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Direct Stimulation of Angiotensin II Type 2 Receptor Initiated After Stroke Ameliorates Ischemic Brain Damage

(2014) Li-Juan Min et al.   AMERICAN JOURNAL OF HYPERTENSION

Activation of Central Angiotensin Type 2 Receptors by Compound 21 Improves Arterial Baroreflex Sensitivity in Rats With Heart Failure

(2014) J. Gao et al.   AMERICAN JOURNAL OF HYPERTENSION

AT 2 Receptor Activation Induces Natriuresis and Lowers Blood Pressure

(2014) Brandon A. Kemp et al.   CIRCULATION RESEARCH

Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats

(2014) Lucinda M. Hilliard et al.   HYPERTENSION

Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production

(2014) Isha Dhande et al.   HYPERTENSION RESEARCH

Angiotensin type 2 receptor in pancreatic islets of adult rats: a novel insulinotropic mediator

(2013) Chunhong Shao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of Angiotensin Type 2 Receptors Partially Ameliorates Streptozotocin-Induced Diabetes in Male Rats by Islet Protection

(2013) Chunhong Shao et al.   ENDOCRINOLOGY

Angiotensin II Type 2 Receptor–Mediated and Nitric Oxide–Dependent Renal Vasodilator Response to Compound 21 Unmasked by Angiotensin-Converting Enzyme Inhibition in Spontaneously Hypertensive Rats In Vivo

(2013) Sofie Brouwers et al.   HYPERTENSION

Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart

(2013) Dilyara Lauer et al.   HYPERTENSION

Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials

(2013) H. Makani et al.   BMJ-British Medical Journal

Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats

(2012) Michaël Shum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice

(2012) Masao Takeda et al.   DIABETES

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

(2012) et al.   EUROPEAN HEART JOURNAL

Direct Angiotensin II Type 2 Receptor Stimulation in N ω -Nitro- l -Arginine-Methyl Ester–Induced Hypertension

(2012) Ludovit Paulis et al.   HYPERTENSION

Inhibition of the renin–angiotensin–aldosterone system

(2012) Massimo Volpe et al.   JOURNAL OF HYPERTENSION

Dual RAAS suppression: recent developments and implications in light of the ALTITUDE study

(2012) Rudolf A de Boer et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

(2012) Hans-Henrik Parving et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct Angiotensin II Type 2 Receptor Stimulation Ameliorates Insulin Resistance in Type 2 Diabetes Mice with PPARγ Activation

(2012) Kousei Ohshima et al.   PLoS One

Aliskiren in Combination with Losartan Reduces Albuminuria Independent of Baseline Blood Pressure in Patients with Type 2 Diabetes and Nephropathy

(2011) F. Persson et al.   Clinical Journal of the American Society of Nephrology

High-Dose Treatment With Telmisartan Induces Monocytic Peroxisome Proliferator-Activated Receptor-γ Target Genes in Patients With the Metabolic Syndrome

(2011) Ilse-Nirmala Bähr et al.   HYPERTENSION

Angiotensin Type 2 Receptor Agonist Compound 21 Reduces Vascular Injury and Myocardial Fibrosis in Stroke-Prone Spontaneously Hypertensive Rats

(2011) Asia Rehman et al.   HYPERTENSION

Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes

(2011) Hermann Haller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Angiotensin I-Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice

(2010) S. M. Bindom et al.   DIABETES

Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor κB

(2010) Franziska Rompe et al.   HYPERTENSION

Angiotensin AT 2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension

(2010) Luis C. Matavelli et al.   HYPERTENSION

Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness

(2010) Charalambos Vlachopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors

(2009) Shin-ichiro Miura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New insights into the regulation of angiotensin receptors

(2009) Masaki Mogi et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Chronic Treatment With Losartan Results in Sufficient Serum Levels of the Metabolite EXP3179 for PPARγ Activation

(2009) Kai Kappert et al.   HYPERTENSION

Next generation multifunctional angiotensin receptor blockers

(2009) Theodore W Kurtz et al.   HYPERTENSION RESEARCH

Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage

(2009) Paolo Gelosa et al.   JOURNAL OF HYPERTENSION

Epoxyeicosatrienoic Acid Agonist Rescues the Metabolic Syndrome Phenotype of HO-2-Null Mice

(2009) K. Sodhi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcriptional Integration of TLR2 and TLR4 Signaling at the NCoR Derepression Checkpoint

(2009) Wendy Huang et al.   MOLECULAR CELL

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Angiotensin II Type 2 Receptor Stimulation

(2008) Elena Kaschina et al.   CIRCULATION

Liver-Specific Peroxisome Proliferator-Activated Receptor   Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan

(2008) M. Clemenz et al.   DIABETES

Inhibiting angiotensin type 1 receptors as a target for diabetes

(2008) Ulrich Kintscher et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

(2008) Johannes FE Mann et al.   LANCET

Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy

(2008) Hans-Henrik Parving et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Over-expression of angiotensin II type 2 receptor (agtr2) decreases collagen accumulation in atherosclerotic plaque

(2007) Abhijit Dandapat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS