Structural basis for selectivity and diversity in angiotensin II receptors

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

(2016) A. J. Venkatakrishnan et al.   NATURE

Recent developments inCrystFEL

(2016) Thomas A. White et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

(2015) Haitao Zhang et al.   CELL

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

(2015) Haitao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Tactical Approaches to Interconverting GPCR Agonists and Antagonists

(2015) Peter I. Dosa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy

(2014) Maree T. Smith et al.   BEHAVIOURAL PHARMACOLOGY

AT 2 Receptor Activation Induces Natriuresis and Lowers Blood Pressure

(2014) Brandon A. Kemp et al.   CIRCULATION RESEARCH

Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor

(2014) P. Balakumar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial

(2014) Andrew S C Rice et al.   LANCET

Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography

(2014) Wei Liu et al.   Nature Protocols

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

(2014) Uwe Weierstall et al.   Nature Communications

Angiotensin II Type 1 and Type 2 Receptor-induced Cell Signaling

(2013) Hiroshi Akazawa et al.   CURRENT PHARMACEUTICAL DESIGN

Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats

(2013) Maree T. Smith et al.   PAIN MEDICINE

A Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonist Produces Analgesia in a Rat Model of Neuropathic Pain by Inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK Activation in the Dorsal Root Ganglia

(2013) Maree T. Smith et al.   PAIN MEDICINE

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Serial Femtosecond Crystallography of G Protein-Coupled Receptors

(2013) W. Liu et al.   SCIENCE

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Angiotensin II type 2 receptor (AT2R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons

(2012) U. Anand et al.   EUROPEAN JOURNAL OF PAIN

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

From the First Selective Non-Peptide AT2 Receptor Agonist to Structurally Related Antagonists

(2012) A. M. S. Murugaiah et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

(2012) Eugene Chun et al.   STRUCTURE

How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations?

(2012) Marie-Odile Guimond et al.   Frontiers in Endocrinology

The Angiotensin II Type 2 Receptor in Brain Functions: An Update

(2012) Marie-Odile Guimond et al.   International Journal of Hypertension

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors

(2009) Shin-ichiro Miura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

(2009) Enzo et al.   Frontiers in Bioscience-Landmark

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy

(2009) Enzo R. Porrello et al.   HYPERTENSION

Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

(2009) Vsevolod Katritch et al.   JOURNAL OF MOLECULAR RECOGNITION

Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation