- Home
- Publications
- Publication Search
- Publication Details
Title
TRPA1 as a drug target—promise and challenges
Authors
Keywords
TRPA1, Drug target, Promise, Challenges
Journal
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Volume 388, Issue 4, Pages 451-463
Publisher
Springer Nature
Online
2015-02-02
DOI
10.1007/s00210-015-1088-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway
- (2015) Mirjam Eberhardt et al. Nature Communications
- Development of novel azabenzofuran TRPA1 antagonists as in vivo tools
- (2014) Katrina W. Copeland et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout
- (2014) Gabriela Trevisan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists
- (2014) Lisa Rooney et al. JOURNAL OF MEDICINAL CHEMISTRY
- Transient Receptor Potential Channel Ankyrin-1 Is Not a Cold Sensor for Autonomic Thermoregulation in Rodents
- (2014) C. de Oliveira et al. JOURNAL OF NEUROSCIENCE
- Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice
- (2014) Gabriela Trevisan et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Significant Determinants of Mouse Pain Behaviour
- (2014) Michael S. Minett et al. PLoS One
- Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
- (2014) Lavanya Moparthi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
- (2014) Victor Meseguer et al. Nature Communications
- Contribution of Transient Receptor Potential Ankyrin 1 to Chronic Pain in Aged Mice With Complete Freund's Adjuvant-Induced Arthritis
- (2014) Sheldon R. Garrison et al. Arthritis & Rheumatology
- Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade
- (2013) G. Trevisan et al. CANCER RESEARCH
- The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
- (2013) Sarah R. Wilson et al. CELL
- Mechanisms involved in abdominal nociception induced by either TRPV1 or TRPA1 stimulation of rat peritoneum
- (2013) Gabriela Trevisan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis
- (2013) Boyi Liu et al. FASEB JOURNAL
- The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6
- (2013) Jeanne de la Roche et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRPA1-Dependent Pruritus in IL-13-Induced Chronic Atopic Dermatitis
- (2013) M.-H. Oh et al. JOURNAL OF IMMUNOLOGY
- The Ion Channel TRPA1 Is Required for Chronic Itch
- (2013) S. R. Wilson et al. JOURNAL OF NEUROSCIENCE
- TRPV1 and TRPA1 Antagonists Prevent the Transition of Acute to Chronic Inflammation and Pain in Chronic Pancreatitis
- (2013) E. S. Schwartz et al. JOURNAL OF NEUROSCIENCE
- Structure of the TRPV1 ion channel determined by electron cryo-microscopy
- (2013) Maofu Liao et al. NATURE
- Methylglyoxal Evokes Pain by Stimulating TRPA1
- (2013) David A. Andersson et al. PLoS One
- Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine
- (2012) Toru Kono et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Quantitative analysis of TRP channel genes in mouse organs
- (2012) Yongwoo Jang et al. ARCHIVES OF PHARMACAL RESEARCH
- C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel
- (2012) Lucie Sura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)
- (2012) Mirjam J. Eberhardt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals
- (2012) M. Sisignano et al. JOURNAL OF NEUROSCIENCE
- Recruitment of Dynamic Endothelial Ca2+Signals by the TRPA1 Channel Activator AITC in Rat Cerebral Arteries
- (2012) Xun Qian et al. MICROCIRCULATION
- TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism
- (2012) Serena Materazzi et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells
- (2012) De-Shou Cao et al. PLoS One
- TRPA1 Is a Polyunsaturated Fatty Acid Sensor in Mammals
- (2012) Arianne L. Motter et al. PLoS One
- Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation
- (2012) Romina Nassini et al. PLoS One
- TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation
- (2012) Richard C. Lennertz et al. PLoS One
- TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide
- (2012) David A. Andersson et al. PLoS One
- TRPA1 and Substance P Mediate Colitis in Mice
- (2011) Matthias A. Engel et al. GASTROENTEROLOGY
- The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons
- (2011) Matthias A. Engel et al. JOURNAL OF GASTROENTEROLOGY
- Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells
- (2011) Indranil Mukhopadhyay et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila
- (2011) Kyeongjin Kang et al. NATURE
- TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
- (2011) Eiji Shigetomi et al. NATURE NEUROSCIENCE
- TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch
- (2011) Sarah R Wilson et al. NATURE NEUROSCIENCE
- Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain
- (2011) Y. Chen et al. NEUROSCIENCE
- Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat
- (2011) Hong Wei et al. PAIN
- Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
- (2011) Jun Chen et al. PAIN
- Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy
- (2011) Ari Koivisto et al. PHARMACOLOGICAL RESEARCH
- Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
- (2011) J. F. Cordero-Morales et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice
- (2010) Eugene Ceppa et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- The Met268Pro Mutation of Mouse TRPA1 Changes the Effect of Caffeine from Activation to Suppression
- (2010) Katsuhiro Nagatomo et al. BIOPHYSICAL JOURNAL
- Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators
- (2010) Nobuaki Takahashi et al. Channels
- Recent advances in the biology and medicinal chemistry of TRPA1
- (2010) Jason C Rech et al. Future Medicinal Chemistry
- Exposure to Low Temperature Induces Elevation of Intracellular Calcium in Cultured Human Keratinocytes
- (2010) Moe Tsutsumi et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- TRPA1 Contributes to Cold Hypersensitivity
- (2010) D. del Camino et al. JOURNAL OF NEUROSCIENCE
- TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats
- (2010) Steve McGaraughty et al. Molecular Pain
- Molecular basis of infrared detection by snakes
- (2010) Elena O. Gracheva et al. NATURE
- A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
- (2010) Barbara Kremeyer et al. NEURON
- TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
- (2010) Wendy M. Knowlton et al. PAIN
- Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors
- (2010) Shannon D. Shields et al. PAIN
- TRPA1 Mediates Mechanical Currents in the Plasma Membrane of Mouse Sensory Neurons
- (2010) Daniel Vilceanu et al. PLoS One
- Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals
- (2009) Hong Wei et al. ANESTHESIOLOGY
- Transient Receptor Potential A1 and Cannabinoid Receptor Activity in Human Normal and Hyperplastic Prostate: Relation to Nerves and Interstitial Cells
- (2009) Christian Gratzke et al. EUROPEAN UROLOGY
- Non-Neuronal Expression of Transient Receptor Potential Type A1 (TRPA1) in Human Skin
- (2009) Ruzanna Atoyan et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons
- (2009) K. Y. Kwan et al. JOURNAL OF NEUROSCIENCE
- Pharmacological Blockade of TRPA1 Inhibits Mechanical Firing in Nociceptors
- (2009) Patrick C Kerstein et al. Molecular Pain
- TRPA1 agonists delay gastric emptying in rats through serotonergic pathways
- (2009) Hitoshi Doihara et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat
- (2009) Hong Wei et al. NEUROPHARMACOLOGY
- TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
- (2009) K. Nozawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TRPA1 acts as a cold sensor in vitro and in vivo
- (2009) Y. Karashima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
- (2009) A. I. Caceres et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TRPA1: A potential target for anti-tussive therapy
- (2009) Thomas E. Taylor-Clark et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- Plasma α-Oxoaldehyde Levels in Diabetic and Nondiabetic Chronic Kidney Disease Patients
- (2008) Keisuke Nakayama et al. AMERICAN JOURNAL OF NEPHROLOGY
- Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
- (2008) Shenglan Wang et al. BRAIN
- Transient receptor potential A1 mediates an osmotically activated ion channel
- (2008) Xu-Feng Zhang et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Transient Receptor Potential A1 (TRPA1) Activity in the Human Urethra—Evidence for a Functional Role for TRPA1 in the Outflow Region
- (2008) Christian Gratzke et al. EUROPEAN UROLOGY
- Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases
- (2008) Bret F. Bessac et al. FASEB JOURNAL
- The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions
- (2008) Yuanyuan Y. Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRPA1 is a major oxidant sensor in murine airway sensory neurons
- (2008) Bret F. Bessac et al. JOURNAL OF CLINICAL INVESTIGATION
- Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels
- (2008) B. Xiao et al. JOURNAL OF NEUROSCIENCE
- Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress
- (2008) D. A. Andersson et al. JOURNAL OF NEUROSCIENCE
- Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
- (2008) J. Chen et al. JOURNAL OF NEUROSCIENCE
- Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal
- (2008) T. E. Taylor-Clark et al. JOURNAL OF PHYSIOLOGY-LONDON
- Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1
- (2008) Lillian Cruz-Orengo et al. Molecular Pain
- HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity
- (2008) Samer R Eid et al. Molecular Pain
- An internal thermal sensor controlling temperature preference in Drosophila
- (2008) Fumika N. Hamada et al. NATURE
- Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade
- (2008) Young Kwon et al. NATURE NEUROSCIENCE
- TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons
- (2008) U. Anand et al. NEUROSCIENCE LETTERS
- Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder
- (2007) Tomi Streng et al. EUROPEAN UROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started