Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?

Engagement of MicroRNA-155 in Exaggerated Oxidative Stress Signal and TRPA1 in the Dorsal Horn of the Spinal Cord and Neuropathic Pain During Chemotherapeutic Oxaliplatin

(2019) Fenghua Miao et al.   NEUROTOXICITY RESEARCH

MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite-allergic rhinitis

(2018) I. Kortekaas Krohn et al.   ALLERGY

Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1)

(2018) Torsten Lowin et al.   BIOCHEMICAL PHARMACOLOGY

A Prospective Study of Chronic Oxaliplatin-Induced Neuropathy in Patients with Colon Cancer: Long-Term Outcomes and Predictors of Severe Oxaliplatin-Induced Neuropathy

(2018) Su-Hyun Kim et al.   Journal of Clinical Neurology

Puerarin ameliorates allodynia and hyperalgesia in rats with peripheral nerve injury

(2018) Zhong-Yuan Xia et al.   Neural Regeneration Research

Oxaliplatin-induced changes in expression of transient receptor potential channels in the dorsal root ganglion as a neuropathic mechanism for cold hypersensitivity

(2018) Akiko Chukyo et al.   NEUROPEPTIDES

Acrolein Contributes to the Neuropathic Pain and Neuron Damage after Ischemic–Reperfusion Spinal Cord Injury

(2018) Yazhou Lin et al.   NEUROSCIENCE

Roles of TRPV1 and TRPA1 in Spontaneous Pain from Inflamed Masseter Muscle

(2018) Sheng Wang et al.   NEUROSCIENCE

Inhibition of TRPA1 Attenuates Doxorubicin-Induced Acute Cardiotoxicity by Suppressing Oxidative Stress, the Inflammatory Response, and Endoplasmic Reticulum Stress

(2018) Zhen Wang et al.   Oxidative Medicine and Cellular Longevity

Analgesic effects of the novel semicarbazide-sensitive amine oxidase inhibitor SZV 1287 in mouse pain models with neuropathic mechanisms: Involvement of transient receptor potential vanilloid 1 and ankyrin 1 receptors

(2018) Ádám Horváth et al.   PHARMACOLOGICAL RESEARCH

Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel

(2018) Lucie Zimova et al.   Science Signaling

Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel

(2018) Lucie Zimova et al.   Science Signaling

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice

(2018) Fabio Arturo Iannotti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Facilitation of MrgprD by TRP-A1 promotes neuropathic pain

(2018) Changming Wang et al.   FASEB JOURNAL

Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis

(2018) Xenia Kodji et al.   FASEB JOURNAL

A TRP channel trio mediates acute noxious heat sensing

(2018) Ine Vandewauw et al.   NATURE

Attenuated lipopolysaccharide-induced inflammatory bladder hypersensitivity in mice deficient of transient receptor potential ankilin1

(2018) Jun Kamei et al.   Scientific Reports

Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model

(2018) Chiara Demartini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice

(2018) Zhen Wang et al.   EBioMedicine

Regulation of transient receptor potential cation channel subfamily V1 protein synthesis by the phosphoinositide 3-kinase/Akt pathway in colonic hypersensitivity

(2017) Shanwei Shen et al.   EXPERIMENTAL NEUROLOGY

TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain

(2017) Matthias G. Schwarz et al.   JOURNAL OF PAIN

Exogenous Acrolein intensifies sensory hypersensitivity after spinal cord injury in rat

(2017) Breanne Butler et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE

(2017) Shan Lu et al.   Molecular Medicine Reports

Oxidative Stress in the Amygdala Contributes to Neuropathic Pain

(2017) B. Sagalajev et al.   NEUROSCIENCE

Muscle Reactive Oxygen Species (ROS) Contribute to Post-Incisional Guarding via the TRPA1 Receptor

(2017) Daisuke Sugiyama et al.   PLoS One

Identification of a putative binding site critical for general anesthetic activation of TRPA1

(2017) Hoai T. Ton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Estrogen Receptor β Stimulation in a Rat Model of Non-Bacterial Prostatic Inflammation

(2017) Shinsuke Mizoguchi et al.   PROSTATE

Sensory TRP channels contribute differentially to skin inflammation and persistent itch

(2017) Jing Feng et al.   Nature Communications

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

(2017) Francesco De Logu et al.   Nature Communications

Regulation of Pain and Itch by TRP Channels

(2017) Carlene Moore et al.   Neuroscience Bulletin

Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

(2017) Beatrice Oehler et al.   Scientific Reports

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis

(2017) Kenta Maruyama et al.   Cell Reports

The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel

(2017) Lenka Marsakova et al.   Frontiers in Molecular Neuroscience

Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin

(2017) Takahito Miyake et al.   Frontiers in Physiology

Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide

(2017) Shohei Oyama et al.   Frontiers in Physiology

Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1

(2017) Mirjam J. Eberhardt et al.   Scientific Reports

Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis

(2016) Paola Prandini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1

(2016) Daniel J. Conklin   Annals of the New York Academy of Sciences

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

(2016) Gabriela Trevisan et al.   BRAIN

Sensing of redox status by TRP channels

(2016) Nozomi Ogawa et al.   CELL CALCIUM

Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation

(2016) Elenice M. Alvarenga et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Frutalin reduces acute and neuropathic nociceptive behaviours in rodent models of orofacial pain

(2016) Marina B.M.V. Damasceno et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms

(2016) Saulo J.F. Mendes et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation

(2016) Jin-Feng Zhao et al.   International Journal of Biological Sciences

TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?

(2016) L. G. B. Ferreira et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Elevated H2O2levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel

(2016) Yoko Kogure et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury

(2016) Zhe Chen et al.   JOURNAL OF NEUROCHEMISTRY

Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1

(2016) Alexandru Babes et al.   JOURNAL OF NEUROSCIENCE

Gout

(2016) Nicola Dalbeth et al.   LANCET

Transcriptome analysis of trigeminal ganglia following masseter muscle inflammation in rats

(2016) Man-Kyo Chung et al.   Molecular Pain

(+)-Borneol attenuates oxaliplatin-induced neuropathic hyperalgesia in mice

(2016) Hai-Hui Zhou et al.   NEUROREPORT

Mechanical antihypersensitivity effect induced by repeated spinal administrations of a TRPA1 antagonist or a gap junction decoupler in peripheral neuropathy

(2016) Hong Wei et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

(2016) Takahito Miyake et al.   Nature Communications

Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain

(2016) Katrin Kistner et al.   Scientific Reports

Intrathecal administration of TRPA1 antagonists attenuate cyclophosphamide-induced cystitis in rats with hyper-reflexia micturition

(2016) Zhipeng Chen et al.   BMC Urology

The Outer Pore and Selectivity Filter of TRPA1

(2016) Adam P. Christensen et al.   PLoS One

Role of TRP channels in the cardiovascular system

(2015) Zhichao Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

(2015) Romina Nassini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient Receptor Potential Channels and Corneal Stromal Inflammation

(2015) Yuka Okada et al.   CORNEA

Role of Transient Receptor Potential Channels in Intestinal Inflammation and Visceral Pain

(2015) Marta Zielińska et al.   INFLAMMATORY BOWEL DISEASES

A synergistic effect of simultaneous TRPA1 and TRPV1 activations on vagal pulmonary C-fiber afferents

(2015) Yu-Jung Lin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Role of calcium ions in the positive interaction between TRPA1 and TRPV1 channels in bronchopulmonary sensory neurons

(2015) Chun-Chun Hsu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury

(2015) Jonghyuck Park et al.   JOURNAL OF NEUROCHEMISTRY

Blocking PAR2 attenuates oxaliplatin-induced neuropathic pain via TRPV1 and releases of substance P and CGRP in superficial dorsal horn of spinal cord

(2015) Kun Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca2+

(2015) An-Hsuan Lin et al.   MEDIATORS OF INFLAMMATION

Transient Receptor Potential Ankyrin 1 that is Induced in Dorsal Root Ganglion Neurons Contributes to Acute Cold Hypersensitivity after Oxaliplatin Administration

(2015) Ken Yamamoto et al.   Molecular Pain

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Changes in transient receptor potential channels in the rat geniculate ganglion after chorda tympani nerve injury

(2015) Emiko Tatsumi et al.   NEUROREPORT

Evidence for TRPA1 involvement in central neural mechanisms in a rat model of dry eye

(2015) A. Katagiri et al.   NEUROSCIENCE

The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats

(2015) J. Asgar et al.   NEUROSCIENCE

Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: Implications for drug access to cytoplasmic targets

(2015) James E. Biggs et al.   NEUROSCIENCE LETTERS

Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice – potential role of TRPA1 in osteoarthritis

(2015) L.J. Moilanen et al.   OSTEOARTHRITIS AND CARTILAGE

Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough

(2015) Kian Fan Chung et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner

(2015) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

Biological Roles of Resolvins and Related Substances in the Resolution of Pain

(2015) Ji Yeon Lim et al.   Biomed Research International

Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 Deficient Mice – Potential Role for Transient Receptor Potential Ankyrin 1 in Gout

(2015) Lauri J. Moilanen et al.   PLoS One

Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice

(2014) R B M Silva et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

(2014) Junhong Gui et al.   CURRENT BIOLOGY

Activation of TLR-4 to produce tumour necrosis factor-α in neuropathic pain caused by paclitaxel

(2014) Z. Wu et al.   EUROPEAN JOURNAL OF PAIN

Identification of Significant Amino Acids in Multiple Transmembrane Domains of Human Transient Receptor Potential Ankyrin 1 (TRPA1) for Activation by Eudesmol, an Oxygenized Sesquiterpene in Hop Essential Oil

(2014) Kazuaki Ohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma

(2014) Yuka Okada et al.   LABORATORY INVESTIGATION

Temperature-Sensitive Transient Receptor Potential Channels in Corneal Tissue Layers and Cells

(2014) Stefan Mergler et al.   OPHTHALMIC RESEARCH

Vagal anandamide signaling via cannabinoid receptor 1 contributes to luminal 5-HT modulation of visceral nociception in rats

(2014) Chen-Chen Feng et al.   PAIN

The Pore-Domain of TRPA1 Mediates the Inhibitory Effect of the Antagonist 6-Methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole

(2014) Hans Moldenhauer et al.   PLoS One

Characterization of a Ligand Binding Site in the Human Transient Receptor Potential Ankyrin 1 Pore

(2013) Göran Klement et al.   BIOPHYSICAL JOURNAL

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

(2013) B Romano et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics

(2013) J Sousa-Valente et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient receptor potential (TRP) channels: a clinical perspective

(2013) Yosuke Kaneko et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade

(2013) G. Trevisan et al.   CANCER RESEARCH

Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis

(2013) Flavia C. Meotti et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain

(2013) Ryosuke Kojima et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

(2013) Boyi Liu et al.   FASEB JOURNAL

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6

(2013) Jeanne de la Roche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1-Dependent Pruritus in IL-13-Induced Chronic Atopic Dermatitis

(2013) M.-H. Oh et al.   JOURNAL OF IMMUNOLOGY

The Ion Channel TRPA1 Is Required for Chronic Itch

(2013) S. R. Wilson et al.   JOURNAL OF NEUROSCIENCE

Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity

(2013) Masayuki Takaishi et al.   Journal of Physiological Sciences

N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor

(2012) Karl S.A. Vallin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system

(2012) L.M.S. Pereira et al.   EUROPEAN JOURNAL OF PAIN

Advances in modulating thermosensory TRP channels

(2012) Antonio Ferrer-Montiel et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1

(2012) Elizabeth S. Fernandes et al.   FASEB JOURNAL

Acute Cold Hypersensitivity Characteristically Induced by Oxaliplatin is Caused by the Enhanced Responsiveness of TRPA1 in Mice

(2012) Meng Zhao et al.   Molecular Pain

Pain and disability retirement: A prospective cohort study

(2012) Peppiina Saastamoinen et al.   PAIN

TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism

(2012) Serena Materazzi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

(2012) Tong Liu et al.   Neuroscience Bulletin

The dilated TRPA1 channel pore state is blocked by amiloride and analogues

(2011) Tue G. Banke   BRAIN RESEARCH

The thermo-TRP ion channel family: properties and therapeutic implications

(2011) Laura Vay et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo

(2011) Lisa Alenmyr et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

TRPV1 and TRPA1 Function and Modulation Are Target Tissue Dependent

(2011) S. Malin et al.   JOURNAL OF NEUROSCIENCE

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

(2011) Y. Chen et al.   NEUROSCIENCE

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

(2011) Romina Nassini et al.   PAIN

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

(2011) Peter Holzer   PHARMACOLOGY & THERAPEUTICS

TRPA1 antagonists as potential analgesic drugs

(2011) E.L. Andrade et al.   PHARMACOLOGY & THERAPEUTICS

Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation

(2010) T. G. Banke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

(2010) Elizabeth S. Fernandes et al.   ARTHRITIS AND RHEUMATISM

Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels

(2010) Martina Mitrovic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

(2010) Nobuaki Takahashi et al.   Channels

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Pharmacology and treatment of neuropathic pains

(2009) Troels S Jensen et al.   CURRENT OPINION IN NEUROLOGY

The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli

(2009) Stuart M. Brierley et al.   GASTROENTEROLOGY

Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels

(2009) Thomas E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pore Dilation Occurs in TRPA1 but Not in TRPM8 Channels

(2009) Jun Chen et al.   Molecular Pain

Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

(2009) Manuela Schmidt et al.   NEURON

Animal models of chemotherapy-evoked painful peripheral neuropathies

(2009) Nicolas Authier et al.   Neurotherapeutics

Selective Targeting of TRPV1 Expressing Sensory Nerve Terminals in the Spinal Cord for Long Lasting Analgesia

(2009) Joseph A. Jeffry et al.   PLoS One

TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

(2009) K. Nozawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient receptor potential A1 mediates an osmotically activated ion channel

(2008) Xu-Feng Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

(2008) Yuanyuan Y. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1 is a major oxidant sensor in murine airway sensory neurons

(2008) Bret F. Bessac et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

(2008) J. Chen et al.   JOURNAL OF NEUROSCIENCE

Molecular and Cellular Limits to Somatosensory Specificity

(2008) Carlos Belmonte et al.   Molecular Pain

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states

(2008) E.J. Cavanaugh et al.   NEUROSCIENCE

Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis

(2008) Jing Yang et al.   NEUROSCIENCE LETTERS

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

(2007) Tomi Streng et al.   EUROPEAN UROLOGY