Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease

Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment

(2018) Xian-Si Zeng et al.   ASN Neuro

Therapeutic approaches to target alpha-synuclein pathology

(2017) Patrik Brundin et al.   EXPERIMENTAL NEUROLOGY

Enhanced Autophagy Contributes to Protective Effects of GM1 Ganglioside Against Aβ1-42-Induced Neurotoxicity and Cognitive Deficits

(2017) Ruwei Dai et al.   NEUROCHEMICAL RESEARCH

The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes

(2017) Rika Kasahara et al.   NEUROSCIENCE

Structure and function of the ULK1 complex in autophagy

(2016) Mary G Lin et al.   CURRENT OPINION IN CELL BIOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding

(2015) Jay S. Schneider et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease

(2015) Qing He et al.   MOLECULAR NEUROBIOLOGY

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Protective Effect of Chinonin in MPTP-Induced C57BL/6 Mouse Model of Parkinson’s Disease

(2014) Guoshuai Feng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial

(2014) PD MED Collaborative Group   LANCET

TFEB

(2013) Mickael Decressac et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

(2012) Jia-Hong Lu et al.   Autophagy

A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients

(2012) Jay S. Schneider et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease

(2011) Terina N. Martinez et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation and Function of Uncoordinated-51 Like Kinase Proteins

(2011) Edmond Y. Chan   ANTIOXIDANTS & REDOX SIGNALING

HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced stress

(2011) Min Su et al.   JOURNAL OF NEUROCHEMISTRY

The Parkinsonian Mimetic, MPP+, Specifically Impairs Mitochondrial Transport in Dopamine Axons

(2011) J. S. Kim-Han et al.   JOURNAL OF NEUROSCIENCE

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Regulatory Mechanisms of Nervous Systems with Glycosphingolipids

(2011) Koichi Furukawa et al.   NEUROCHEMICAL RESEARCH

Gangliosides induce autophagic cell death in astrocytes

(2010) Jaegyu Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

GM1 ganglioside in Parkinson's disease: Results of a five year open study

(2010) Jay S. Schneider et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Exogenous gangliosides increase the release of brain-derived neurotrophic factor

(2010) Seung T. Lim et al.   NEUROPHARMACOLOGY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Enhanced autophagy and mitochondrial aberrations in murine GM1-gangliosidosis

(2008) Ayumi Takamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS