Several New Putative Bacterial ADP-Ribosyltransferase Toxins Are Revealed from In Silico Data Mining, Including the Novel Toxin Vorin, Encoded by the Fire Blight Pathogen Erwinia amylovora

Characterization of C3larvinA, a novel RhoA-targeting ADP-ribosyltransferase toxin produced by the honey bee pathogen, Paenibacillus larvae

(2020) Madison Turner et al.   BIOSCIENCE REPORTS

ParST is a widespread toxin–antitoxin module that targets nucleotide metabolism

(2019) Frank J. Piscotta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TagF-mediated repression of bacterial type VI secretion systems involves a direct interaction with the cytoplasmic protein Fha

(2018) Jer-Sheng Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phylogeny and putative virulence gene analysis of Bartonella bovis

(2018) Sun Tee TAY et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Recent advances in the understanding of Xanthomonas citri ssp. citri pathogenesis and citrus canker disease management

(2018) Christopher M. Ference et al.   MOLECULAR PLANT PATHOLOGY

Effector–Immunity Pairs Provide the T6SS Nanomachine its Offensive and Defensive Capabilities

(2018) Xiaobing Yang et al.   MOLECULES

Deregulation of autophagy and vesicle trafficking in Parkinson’s disease

(2018) Patricia Sheehan et al.   NEUROSCIENCE LETTERS

Dynamics of Scabin toxin. A proposal for the binding mode of the DNA substrate

(2018) Miguel R. Lugo et al.   PLoS One

Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection

(2018) Niladri Bhusan Pati et al.   Scientific Reports

Fire blight host-pathogen interaction: proteome profiles of Erwinia amylovora infecting apple rootstocks

(2018) Michelle Holtappels et al.   Scientific Reports

PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems

(2017) Jiale Ma et al.   ENVIRONMENTAL MICROBIOLOGY

Characterization of the toxin Plx2A, a RhoA-targeting ADP-ribosyltransferase produced by the honey bee pathogen Paenibacillus larvae

(2017) Julia Ebeling et al.   ENVIRONMENTAL MICROBIOLOGY

Distinct roles of the polarity factors Boi1 and Boi2 in the control of exocytosis and abscission in budding yeast

(2017) Aina Masgrau et al.   MOLECULAR BIOLOGY OF THE CELL

Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex

(2017) Goran Stjepanovic et al.   MOLECULAR CELL

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

ModFOLD6: an accurate web server for the global and local quality estimation of 3D protein models

(2017) Ali H. A. Maghrabi et al.   NUCLEIC ACIDS RESEARCH

The Type VI Secretion System: A Dynamic System for Bacterial Communication?

(2017) Mathias Gallique et al.   Frontiers in Microbiology

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

(2016) J. M. Backer   BIOCHEMICAL JOURNAL

Genetic analysis of human clinical isolates of Lactococcus garvieae : Relatedness with isolates from foods

(2016) Mercedes Reguera-Brito et al.   INFECTION GENETICS AND EVOLUTION

Scabin, a Novel DNA-acting ADP-ribosyltransferase fromStreptomyces scabies

(2016) Bronwyn Lyons et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA

(2016) Gytis Jankevicius et al.   MOLECULAR CELL

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

(2016) Alexander Hahn et al.   MOLECULAR CELL

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Protein ADP-Ribosylation Takes Control in Plant–Bacterium Interactions

(2016) Baomin Feng et al.   PLoS Pathogens

Structure, Biology, and Therapeutic Application of Toxin–Antitoxin Systems in Pathogenic Bacteria

(2016) Ki-Young Lee et al.   Toxins

Membrane Trafficking in the Yeast Saccharomyces cerevisiae Model

(2015) Serge Feyder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intraspecies Competition in Serratia marcescens Is Mediated by Type VI-Secreted Rhs Effectors and a Conserved Effector-Associated Accessory Protein

(2015) Juliana Alcoforado Diniz et al.   JOURNAL OF BACTERIOLOGY

Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure

(2015) Akiyuki Toda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Composition, function, and regulation of T6SS in Pseudomonas aeruginosa

(2015) Lihua Chen et al.   MICROBIOLOGICAL RESEARCH

Atg27 Tyrosine Sorting Motif is Important for Its Trafficking and Atg9 Localization

(2015) Verónica A. Segarra et al.   TRAFFIC

New Players in the Toxin Field: Polymorphic Toxin Systems in Bacteria

(2015) Anne Jamet et al.   mBio

Control of fire blight (Erwinia amylovora) on apple trees with trunk-injected plant resistance inducers and antibiotics and assessment of induction of pathogenesis-related protein genes

(2015) Srd¯an G. Aćimović et al.   Frontiers in Plant Science

Agrobacterium tumefaciens Deploys a Superfamily of Type VI Secretion DNase Effectors as Weapons for Interbacterial Competition In Planta

(2014) Lay-Sun Ma et al.   Cell Host & Microbe

Expression of the Bacterial Type III Effector DspA/E inSaccharomyces cerevisiaeDown-regulates the Sphingolipid Biosynthetic Pathway Leading to Growth Arrest

(2014) Sabrina Siamer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C3larvin Toxin, an ADP-ribosyltransferase fromPaenibacillus larvae

(2014) Daniel Krska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The VgrG Proteins Are “à la Carte” Delivery Systems for Bacterial Type VI Effectors

(2014) Abderrahman Hachani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Tc toxin action revealed in molecular detail

(2014) Dominic Meusch et al.   NATURE

Novel bacterial ADP-ribosylating toxins: structure and function

(2014) Nathan C. Simon et al.   NATURE REVIEWS MICROBIOLOGY

Type VI secretion system effectors: poisons with a purpose

(2014) Alistair B. Russell et al.   NATURE REVIEWS MICROBIOLOGY

ADP-Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity

(2014) Santanu Bose et al.   mBio

The pleiotropic roles of sphingolipid signaling in autophagy

(2014) Y Li et al.   Cell Death & Disease

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

(2014) Sulochanadevi Baskaran et al.   eLife

A bird’s-eye view of autophagy

(2013) Petro Starokadomskyy et al.   Autophagy

Comparative genome analysis of Spiroplasma melliferum IPMB4A, a honeybee-associated bacterium

(2013) Wen-Sui Lo et al.   BMC GENOMICS

Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast

(2013) N. A. Gaur et al.   GENETICS

ADP-ribosylation of Translation Elongation Factor 2 by Diphtheria Toxin in Yeast Inhibits Translation and Cell Separation

(2013) Maria K. Mateyak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Type VI Effector-Immunity Complex (Tae4-Tai4) Provides Novel Insights into the Inhibition Mechanism of the Effector by Its Immunity Protein

(2013) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

(2013) Jason N. Busby et al.   NATURE

Comparative Genomics of 12 Strains of Erwinia amylovora Identifies a Pan-Genome with a Large Conserved Core

(2013) Rachel A. Mann et al.   PLoS One

Strain-alleviation model of ADP-ribosylation

(2013) Thomas Jank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex

(2013) Toshiharu Tsurumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhs proteins from diverse bacteria mediate intercellular competition

(2013) S. Koskiniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fire Blight: Applied Genomic Insights of the Pathogen and Host

(2012) Mickael Malnoy et al.   Annual Review of Phytopathology

Improved model quality assessment using ProQ2

(2012) Arjun Ray et al.   BMC BIOINFORMATICS

Enterobacter cloacaecomplex: clinical impact and emerging antibiotic resistance

(2012) Maria Lina Mezzatesta et al.   Future Microbiology

Genome Sequence of the Bacteriocin-Producing Strain Lactococcus garvieae DCC43

(2012) C. Gabrielsen et al.   JOURNAL OF BACTERIOLOGY

Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase fromBacillus cereus

(2012) Danielle Visschedyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Plasmids in a Human Clinical Strain of Lactococcus garvieae

(2012) Mónica Aguado-Urda et al.   PLoS One

Role of autophagy in disease resistance and hypersensitive response-associated cell death

(2011) D Hofius et al.   CELL DEATH AND DIFFERENTIATION

Actin as target for modification by bacterial protein toxins

(2011) Klaus Aktories et al.   FEBS Journal

A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

(2011) John E. Weldon et al.   FEBS Journal

Application of Spiroplasma melliferum Proteogenomic Profiling for the Discovery of Virulence Factors and Pathogenicity Mechanisms in Host-associated Spiroplasmas

(2011) Dmitry Alexeev et al.   JOURNAL OF PROTEOME RESEARCH

HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment

(2011) Michael Remmert et al.   NATURE METHODS

A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems

(2011) Dapeng Zhang et al.   NUCLEIC ACIDS RESEARCH

Cellular Vacuoles Induced by Mycoplasma pneumoniae CARDS Toxin Originate from Rab9-Associated Compartments

(2011) Coreen Johnson et al.   PLoS One

Atomic-Level Protein Structure Refinement Using Fragment-Guided Molecular Dynamics Conformation Sampling

(2011) Jian Zhang et al.   STRUCTURE

Identification of Functional Toxin/Immunity Genes Linked to Contact-Dependent Growth Inhibition (CDI) and Rearrangement Hotspot (Rhs) Systems

(2011) Stephen J. Poole et al.   PLoS Genetics

Newly Discovered and Characterized Antivirulence Compounds Inhibit Bacterial Mono-ADP-Ribosyltransferase Toxins

(2010) Zachari Turgeon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Partial Chromosome Sequence of Spiroplasma citri Reveals Extensive Viral Invasion and Important Gene Decay

(2010) P. Carle et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome Sequence of an Erwinia amylovora Strain with Pathogenicity Restricted to Rubus Plants

(2010) R. Powney et al.   JOURNAL OF BACTERIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

An improved yeast transformation method for the generation of very large human antibody libraries

(2010) Lorenzo Benatuil et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Cholera- and Anthrax-Like Toxins Are among Several New ADP-Ribosyltransferases

(2010) Robert J. Fieldhouse et al.   PLoS Computational Biology

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ceramide-induced autophagy: To junk or to protect cells?

(2009) Sophie Pattingre et al.   Autophagy

Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway,

(2009) Erin J. Heenan et al.   BIOCHEMISTRY

Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement

(2009) Andrew P Jackson et al.   BMC GENOMICS

Yeast as a tool for characterizing mono-ADP-ribosyltransferase toxins

(2009) Zachari Turgeon et al.   FEMS MICROBIOLOGY LETTERS

Mitochondrial F1Fo-ATP Synthase: The Small Subunits e and g Associate with Monomeric Complexes to Trigger Dimerization

(2009) Karina Wagner et al.   JOURNAL OF MOLECULAR BIOLOGY

The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin

(2008) Pradeep K. Gupta et al.   CELLULAR MICROBIOLOGY

Chlamydia-like bacteria in respiratory samples of community-acquired pneumonia patients

(2008) Susanne Haider et al.   FEMS MICROBIOLOGY LETTERS

Cholix Toxin, a Novel ADP-ribosylating Factor fromVibrio cholerae

(2008) René Jørgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH

An in Vivo Map of the Yeast Protein Interactome

(2008) K. Tarassov et al.   SCIENCE

Needle in the haystack: structure-based toxin discovery

(2008) Robert J. Fieldhouse et al.   TRENDS IN BIOCHEMICAL SCIENCES

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY