Type VI secretion system effectors: poisons with a purpose

Structural basis for type VI secreted peptidoglycanDL-endopeptidase function, specificity and neutralization inSerratia marcescens

(2013) Velupillai Srikannathasan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural insights into the inhibition of type VI effector Tae3 by its immunity protein Tai3

(2013) Cheng Dong et al.   BIOCHEMICAL JOURNAL

Colonization strategies of Pseudomonas fluorescens Pf0-1: activation of soil-specific genes important for diverse and specific environments

(2013) Katila Varivarn et al.   BMC MICROBIOLOGY

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Exploring host-microbiota interactions in animal models and humans

(2013) A. D. Kostic et al.   GENES & DEVELOPMENT

Structure of the Type VI Effector-Immunity Complex (Tae4-Tai4) Provides Novel Insights into the Inhibition Mechanism of the Effector by Its Immunity Protein

(2013) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair

(2013) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lytic Activity of theVibrio choleraeType VI Secretion Toxin VgrG-3 Is Inhibited by the Antitoxin TsaB

(2013) Teresa M. Brooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in Aeromonas hydrophila SSU pathogenesis

(2013) J. Sha et al.   MICROBIOLOGY-SGM

Proteomic Identification of Novel Secreted Antibacterial Toxins of theSerratia marcescensType VI Secretion System

(2013) Maximilian J. Fritsch et al.   MOLECULAR & CELLULAR PROTEOMICS

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

(2013) Julie M. Silverman et al.   MOLECULAR CELL

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

(2013) Alistair B. Russell et al.   NATURE

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

(2013) Mikhail M. Shneider et al.   NATURE

Competition sensing: the social side of bacterial stress responses

(2013) Daniel M. Cornforth et al.   NATURE REVIEWS MICROBIOLOGY

Acinetobacter baumannii Utilizes a Type VI Secretion System for Bacterial Competition

(2013) Michael D. Carruthers et al.   PLoS One

Delivery of CdiA Nuclease Toxins into Target Cells during Contact-Dependent Growth Inhibition

(2013) Julia S. Webb et al.   PLoS One

Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2

(2013) Dor Salomon et al.   PLoS One

Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae

(2013) T. G. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhs proteins from diverse bacteria mediate intercellular competition

(2013) S. Koskiniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial contact-dependent growth inhibition

(2013) Zachary C. Ruhe et al.   TRENDS IN MICROBIOLOGY

Two Independent Pathways for Self-Recognition in Proteus mirabilis Are Linked by Type VI-Dependent Export

(2013) L. M. Wenren et al.   mBio

Imaging Type VI Secretion-Mediated Bacterial Killing

(2013) Yannick R. Brunet et al.   Cell Reports

Dual Expression Profile of Type VI Secretion System Immunity Genes Protects Pandemic Vibrio cholerae

(2013) Sarah T. Miyata et al.   PLoS Pathogens

Bacterial Persistence and Toxin-Antitoxin Loci

(2012) Kenn Gerdes et al.   Annual Review of Microbiology

Promoter Swapping Unveils the Role of the Citrobacter rodentium CTS1 Type VI Secretion System in Interbacterial Competition

(2012) Erwan Gueguen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Widespread Bacterial Type VI Secretion Effector Superfamily Identified Using a Heuristic Approach

(2012) Alistair B. Russell et al.   Cell Host & Microbe

Crystal structure of type VI effector Tse1 fromPseudomonas aeruginosa

(2012) Heng Zhang et al.   FEBS LETTERS

Hcp2, a Secreted Protein of the Phytopathogen Pseudomonas syringae pv. Tomato DC3000, Is Required for Fitness for Competition against Bacteria and Yeasts

(2012) Minna Haapalainen et al.   JOURNAL OF BACTERIOLOGY

Structural Insights into thePseudomonas aeruginosaType VI Virulence Effector Tse1 Bacteriolysis and Self-protection Mechanisms

(2012) Jingjin Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins

(2012) Yuichi Otsuka et al.   MOLECULAR MICROBIOLOGY

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster ofSerratia marcescens

(2012) Grant English et al.   MOLECULAR MICROBIOLOGY

The toxin/immunity network of Burkholderia pseudomallei contact-dependent growth inhibition (CDI) systems

(2012) Kiel Nikolakakis et al.   MOLECULAR MICROBIOLOGY

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

Microbial life in the phyllosphere

(2012) Julia A. Vorholt   NATURE REVIEWS MICROBIOLOGY

Structural biology of type VI secretion systems

(2012) E. Cascales et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structural Insights into the Effector – Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa

(2012) Juliane Benz et al.   PLoS One

Constitutive Type VI Secretion System Expression Gives Vibrio cholerae Intra- and Interspecific Competitive Advantages

(2012) Daniel Unterweger et al.   PLoS One

Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota

(2012) A. F. Goddard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decade-long bacterial community dynamics in cystic fibrosis airways

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword

(2012) M. LeRoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 6 Secretion Dynamics Within and Between Bacterial Cells

(2012) M. Basler et al.   SCIENCE

Structure of a Peptidoglycan Amidase Effector Targeted to Gram-Negative Bacteria by the Type VI Secretion System

(2012) Seemay Chou et al.   Cell Reports

The Burkholderia bcpAIOB Genes Define Unique Classes of Two-Partner Secretion and Contact Dependent Growth Inhibition Systems

(2012) Melissa S. Anderson et al.   PLoS Genetics

Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein

(2012) Mo Li et al.   PLoS Pathogens

Acid-Induced Type VI Secretion System Is Regulated by ExoR-ChvG/ChvI Signaling Cascade in Agrobacterium tumefaciens

(2012) Chih-Feng Wu et al.   PLoS Pathogens

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

Comparative genomics of the type VI secretion systems of Pantoea and Erwinia species reveals the presence of putative effector islands that may be translocated by the VgrG and Hcp proteins

(2011) Pieter De Maayer et al.   BMC GENOMICS

Microbial communities involved in enhanced biological phosphorus removal from wastewater—a model system in environmental biotechnology

(2011) Per Halkjær Nielsen et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c-di-GMP signalling

(2011) Joana A. Moscoso et al.   ENVIRONMENTAL MICROBIOLOGY

Vibrio cholerae Requires the Type VI Secretion System Virulence Factor VasX To Kill Dictyostelium discoideum

(2011) Sarah T. Miyata et al.   INFECTION AND IMMUNITY

Pathoadaptive Conditional Regulation of the Type VI Secretion System in Vibrio cholerae O1 Strains

(2011) Takahiko Ishikawa et al.   INFECTION AND IMMUNITY

The oral metagenome in health and disease

(2011) Pedro Belda-Ferre et al.   ISME Journal

The Opportunistic Pathogen Serratia marcescens Utilizes Type VI Secretion To Target Bacterial Competitors

(2011) S. L. Murdoch et al.   JOURNAL OF BACTERIOLOGY

Type VI Secretion System inPseudomonas aeruginosa

(2011) Abderrahman Hachani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxin-Antitoxin Systems ofMycobacterium smegmatisAre Essential for Cell Survival

(2011) Rebekah Frampton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type VI secretion delivers bacteriolytic effectors to target cells

(2011) Alistair B. Russell et al.   NATURE

Regulation of growth and death in Escherichia coli by toxin–antitoxin systems

(2011) Yoshihiro Yamaguchi et al.   NATURE REVIEWS MICROBIOLOGY

Genetic Analysis of Anti-Amoebae and Anti-Bacterial Activities of the Type VI Secretion System in Vibrio cholerae

(2011) Jun Zheng et al.   PLoS One

Social conflict drives the evolutionary divergence of quorum sensing

(2011) A. Eldar   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiology of the skin and the role of biofilms in infection

(2011) Steven L Percival et al.   International Wound Journal

An Epigenetic Switch Involving Overlapping Fur and DNA Methylation Optimizes Expression of a Type VI Secretion Gene Cluster

(2011) Yannick R. Brunet et al.   PLoS Genetics

Identification of Functional Toxin/Immunity Genes Linked to Contact-Dependent Growth Inhibition (CDI) and Rearrangement Hotspot (Rhs) Systems

(2011) Stephen J. Poole et al.   PLoS Genetics

Spiteful Interactions in a Natural Population of the Bacterium Xenorhabdus bovienii

(2010) Hadas Hawlena et al.   AMERICAN NATURALIST

Kin Discrimination and Cooperation in Microbes

(2010) Joan E. Strassmann et al.   Annual Review of Microbiology

Structure and Regulation of the Type VI Secretion System

(2010) Julie M. Silverman et al.   Annual Review of Microbiology

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

(2010) Rachel D. Hood et al.   Cell Host & Microbe

Inactivation of the GacA response regulator in Pseudomonas fluorescens Pf-5 has far-reaching transcriptomic consequences

(2010) Karl A. Hassan et al.   ENVIRONMENTAL MICROBIOLOGY

Nooks and Crannies in Type VI Secretion Regulation

(2010) C. S. Bernard et al.   JOURNAL OF BACTERIOLOGY

A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria

(2010) Stephanie K. Aoki et al.   NATURE

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Airway Microbiota and Pathogen Abundance in Age-Stratified Cystic Fibrosis Patients

(2010) Michael J. Cox et al.   PLoS One

The Vibrio cholerae type VI secretion system displays antimicrobial properties

(2010) D. L. MacIntyre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What is type VI secretion doing in all those bugs?

(2010) Sandra Schwarz et al.   TRENDS IN MICROBIOLOGY

Emergence of Spatial Structure in Cell Groups and the Evolution of Cooperation

(2010) Carey D. Nadell et al.   PLoS Computational Biology

Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions

(2010) Sandra Schwarz et al.   PLoS Pathogens

Beta-lactam antibiotics: from antibiosis to resistance and bacteriology

(2009) KOK-FAI KONG et al.   APMIS

Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes

(2009) Carlos J Blondel et al.   BMC GENOMICS

Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?

(2009) Frédéric Boyer et al.   BMC GENOMICS

Social Conflict in Centimeter-and Global-Scale Populations of the Bacterium Myxococcus xanthus

(2009) Michiel Vos et al.   CURRENT BIOLOGY

Bacterial landlines: contact-dependent signaling in bacterial populations

(2009) Matthew G Blango et al.   CURRENT OPINION IN MICROBIOLOGY

A Type VI Secretion System Effector Protein, VgrG1, from Aeromonas hydrophila That Induces Host Cell Toxicity by ADP Ribosylation of Actin

(2009) G. Suarez et al.   JOURNAL OF BACTERIOLOGY

Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models

(2009) Jennilee B. Robinson et al.   MICROBIAL PATHOGENESIS

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis

(2009) B. Lesic et al.   MICROBIOLOGY-SGM

Quorum Sensing Regulation of the Two hcp Alleles in Vibrio cholerae O1 Strains

(2009) Takahiko Ishikawa et al.   PLoS One

Structural similarity of tailed phages and pathogenic bacterial secretion systems

(2009) S. Kanamaru   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin

(2009) P. G. Leiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep-Sea Archaea Fix and Share Nitrogen in Methane-Consuming Microbial Consortia

(2009) A. E. Dekas et al.   SCIENCE

Bacterial Toxin–Antitoxin Systems: More Than Selfish Entities?

(2009) Laurence Van Melderen et al.   PLoS Genetics

Bacteriophage lysins as effective antibacterials

(2008) Vincent A Fischetti   CURRENT OPINION IN MICROBIOLOGY

SciN Is an Outer Membrane Lipoprotein Required for Type VI Secretion in Enteroaggregative Escherichia coli

(2008) M.-S. Aschtgen et al.   JOURNAL OF BACTERIOLOGY

Microarray profiling of host-extract-induced genes and characterization of the type VI secretion cluster in the potato pathogen Pectobacterium atrosepticum

(2008) L. Mattinen et al.   MICROBIOLOGY-SGM

Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB

(2008) Stephanie K. Aoki et al.   MOLECULAR MICROBIOLOGY

Physiological heterogeneity in biofilms

(2008) Philip S. Stewart et al.   NATURE REVIEWS MICROBIOLOGY

Genetic Determinants of Self Identity and Social Recognition in Bacteria

(2008) K. A. Gibbs et al.   SCIENCE

Microbial Ecology of Ocean Biogeochemistry: A Community Perspective

(2008) S. L. Strom   SCIENCE

Genetic Diversity and Microevolution of Burkholderia pseudomallei in the Environment

(2008) Narisara Chantratita et al.   PLoS Neglected Tropical Diseases

Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila

(2007) Giovanni Suarez et al.   MICROBIAL PATHOGENESIS