PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems

Bacteroides fragilistype VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species

(2016) Maria Chatzidaki-Livanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aim, Load, Fire: The Type VI Secretion System, a Bacterial Nanoweapon

(2016) Francesca R. Cianfanelli et al.   TRENDS IN MICROBIOLOGY

VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System

(2016) Francesca R. Cianfanelli et al.   PLoS Pathogens

An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

(2015) John C. Whitney et al.   CELL

Structure of the Type VI Secretion System Contractile Sheath

(2015) Mikhail Kudryashev et al.   CELL

Chimeric adaptor proteins translocate diverse type VI secretion system effectors in Vibrio cholerae

(2015) D. Unterweger et al.   EMBO JOURNAL

Intraspecies Competition in Serratia marcescens Is Mediated by Type VI-Secreted Rhs Effectors and a Conserved Effector-Associated Accessory Protein

(2015) Juliana Alcoforado Diniz et al.   JOURNAL OF BACTERIOLOGY

Identification of divergent type VI secretion effectors using a conserved chaperone domain

(2015) Xiaoye Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ecology of the microbiome: Networks, competition, and stability

(2015) K. Z. Coyte et al.   SCIENCE

Secretome Analysis of Vibrio cholerae Type VI Secretion System Reveals a New Effector-Immunity Pair

(2015) Emrah Altindis et al.   mBio

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization

(2015) Yannick R. Brunet et al.   PLoS Genetics

The Extraintestinal Pathogenic Escherichia coli Factor RqlI Constrains the Genotoxic Effects of the RecQ-Like Helicase RqlH

(2015) Colin W. Russell et al.   PLoS Pathogens

Two Functional Type VI Secretion Systems in Avian Pathogenic Escherichia coli Are Involved in Different Pathogenic Pathways

(2014) Jiale Ma et al.   INFECTION AND IMMUNITY

The VgrG Proteins Are “à la Carte” Delivery Systems for Bacterial Type VI Effectors

(2014) Abderrahman Hachani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetically distinct pathways guide effector export through the type VI secretion system

(2014) John C. Whitney et al.   MOLECULAR MICROBIOLOGY

Type VI secretion system effectors: poisons with a purpose

(2014) Alistair B. Russell et al.   NATURE REVIEWS MICROBIOLOGY

Marker for type VI secretion system effectors

(2014) D. Salomon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors

(2014) Eric Durand et al.   TRENDS IN MICROBIOLOGY

The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition

(2014) Daniel Unterweger et al.   Nature Communications

Selection of Orphan Rhs Toxin Expression in Evolved Salmonella enterica Serovar Typhimurium

(2014) Sanna Koskiniemi et al.   PLoS Genetics

Exploring host-microbiota interactions in animal models and humans

(2013) A. D. Kostic et al.   GENES & DEVELOPMENT

Genetic diversity and features analysis of type VI secretion systems loci in avian pathogenic Escherichia coli by wide genomic scanning

(2013) Jiale Ma et al.   INFECTION GENETICS AND EVOLUTION

Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair

(2013) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lytic Activity of theVibrio choleraeType VI Secretion Toxin VgrG-3 Is Inhibited by the Antitoxin TsaB

(2013) Teresa M. Brooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Identification of Novel Secreted Antibacterial Toxins of theSerratia marcescensType VI Secretion System

(2013) Maximilian J. Fritsch et al.   MOLECULAR & CELLULAR PROTEOMICS

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

(2013) Julie M. Silverman et al.   MOLECULAR CELL

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

(2013) Alistair B. Russell et al.   NATURE

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

(2013) Mikhail M. Shneider et al.   NATURE

Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae

(2013) T. G. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhs proteins from diverse bacteria mediate intercellular competition

(2013) S. Koskiniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Independent Pathways for Self-Recognition in Proteus mirabilis Are Linked by Type VI-Dependent Export

(2013) L. M. Wenren et al.   mBio

Comprehensive Assignment of Roles for Salmonella Typhimurium Genes in Intestinal Colonization of Food-Producing Animals

(2013) Roy R. Chaudhuri et al.   PLoS Genetics

Dual Expression Profile of Type VI Secretion System Immunity Genes Protects Pandemic Vibrio cholerae

(2013) Sarah T. Miyata et al.   PLoS Pathogens

A Novel Two-Component Signaling System Facilitates Uropathogenic Escherichia coli's Ability to Exploit Abundant Host Metabolites

(2013) Wentong Cai et al.   PLoS Pathogens

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

(2012) Dapeng Zhang et al.   Biology Direct

A Widespread Bacterial Type VI Secretion Effector Superfamily Identified Using a Heuristic Approach

(2012) Alistair B. Russell et al.   Cell Host & Microbe

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster ofSerratia marcescens

(2012) Grant English et al.   MOLECULAR MICROBIOLOGY

An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome

(2012) V. L. Kung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Cloned RhsA Sequences Perturbs the Cellular Translational Machinery in Escherichia coli

(2011) K. Aggarwal et al.   JOURNAL OF BACTERIOLOGY

Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study

(2011) Martina Bielaszewska et al.   LANCET INFECTIOUS DISEASES

Type VI secretion delivers bacteriolytic effectors to target cells

(2011) Alistair B. Russell et al.   NATURE

A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems

(2011) Dapeng Zhang et al.   NUCLEIC ACIDS RESEARCH

Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems

(2011) Lakshminarayan M. Iyer et al.   NUCLEIC ACIDS RESEARCH

Genetic Analysis of Anti-Amoebae and Anti-Bacterial Activities of the Type VI Secretion System in Vibrio cholerae

(2011) Jun Zheng et al.   PLoS One

Identification of Functional Toxin/Immunity Genes Linked to Contact-Dependent Growth Inhibition (CDI) and Rearrangement Hotspot (Rhs) Systems

(2011) Stephen J. Poole et al.   PLoS Genetics

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

(2010) Rachel D. Hood et al.   Cell Host & Microbe

Nooks and Crannies in Type VI Secretion Regulation

(2010) C. S. Bernard et al.   JOURNAL OF BACTERIOLOGY

A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria

(2010) Stephanie K. Aoki et al.   NATURE

Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement

(2009) Andrew P Jackson et al.   BMC GENOMICS

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis

(2009) B. Lesic et al.   MICROBIOLOGY-SGM