The pleiotropic roles of sphingolipid signaling in autophagy

Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3

(2014) Hiroshi Aoki et al.   Autophagy

Fenretinide induces autophagic cell death in caspase-defective breast cancer cells

(2014) Barbara Fazi et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Regulation of autophagy by ceramide-CD95-PERK signaling

(2014) Margaret A. Park et al.   Autophagy

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

(2014) E Gabandé-Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Control of autophagy maturation by acid sphingomyelinase in mouse coronary arterial smooth muscle cells: protective role in atherosclerosis

(2014) Xiang Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

Regulation of Autophagy by Sphingolipids

(2012) Carmen Bedia et al.   Anti-Cancer Agents in Medicinal Chemistry

Ceramide-Based Therapeutics for the Treatment of Cancer

(2012) Brian M. Barth et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagy in lysosomal storage disorders

(2012) Andrew P. Lieberman et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells

(2012) Samy A. F. Morad et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Sphingolipid Signaling in Metabolic Disorders

(2012) Timothy Hla et al.   Cell Metabolism

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Impaired proteolysis underlies autophagic dysfunction in Niemann–Pick type C disease

(2012) Matthew J. Elrick et al.   HUMAN MOLECULAR GENETICS

Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy

(2012) Vincenzo Gagliostro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

(2012) Makoto Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages

(2012) Joel D. Schilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

A comprehensive glossary of autophagy-related molecules and processes (2ndedition)

(2011) Daniel J Klionsky et al.   Autophagy

Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae

(2011) Maki Yamagata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

(2011) Daniel Canals et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

(2011) M. A. Dickson et al.   CLINICAL CANCER RESEARCH

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide

(2011) Qing Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage

(2011) Sandrine Lépine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroceramide-based Response to Hypoxia

(2011) Cecilia M. Devlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells

(2011) Ting Sun et al.   Journal of Translational Medicine

1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation

(2011) Teng Yu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Autophagy Inhibition Enhances Daunorubicin-Induced Apoptosis in K562 Cells

(2011) Weidong Han et al.   PLoS One

A comprehensive glossary of autophagy-related molecules and processes

(2010) Daniel J. Klionsky et al.   Autophagy

Autophagosome maturation is impaired in Fabry disease

(2010) Marc Chévrier et al.   Autophagy

Gangliosides induce autophagic cell death in astrocytes

(2010) Jaegyu Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Angioprevention with fenretinide: Targeting angiogenesis in prevention and therapeutic strategies

(2010) Ilaria Sogno et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: Implications for future therapeutic approaches

(2010) Stephen M. Schleicher et al.   DRUG RESISTANCE UPDATES

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Saposin C mutations in Gaucher disease patients resulting in lysosomal lipid accumulation, saposin C deficiency, but normal prosaposin processing and sorting

(2010) A. M. Vaccaro et al.   HUMAN MOLECULAR GENETICS

Kdo2-Lipid A, a TLR4-specific Agonist, Inducesde NovoSphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

(2010) Kacee Sims et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB as a common signaling pathway in ganglioside-induced autophagic cell death and activation of astrocytes

(2010) Jaegyu Hwang et al.   JOURNAL OF NEUROIMMUNOLOGY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells

(2010) V. Beljanski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Autophagy basics

(2010) Isei Tanida   MICROBIOLOGY AND IMMUNOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

White and gray matter alterations in adults with Niemann-Pick disease type C: A cross-sectional study

(2010) M. Walterfang et al.   NEUROLOGY

Pathology and Current Treatment of Neurodegenerative Sphingolipidoses

(2010) Matthias Eckhardt   NEUROMOLECULAR MEDICINE

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide

(2010) L S Turner et al.   PROSTATE CANCER AND PROSTATIC DISEASES

S1P5 is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells

(2009) Chi-Lun Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The paradox of autophagy and its implication in cancer etiology and therapy

(2009) Avital Eisenberg-Lerner et al.   APOPTOSIS

Safingol (l-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway

(2009) Jesse Coward et al.   Autophagy

Mechanisms and consequences of impaired lipid trafficking in Niemann–Pick type C1-deficient mammalian cells

(2009) Barbara Karten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells

(2009) Paola Signorelli et al.   CANCER LETTERS

Natural Sphingadienes Inhibit Akt-Dependent Signaling and Prevent Intestinal Tumorigenesis

(2009) H. Fyrst et al.   CANCER RESEARCH

In Vitroandin VivoAnti-angiogenic Activities and Inhibition of Hormone-Dependent and -Independent Breast Cancer Cells by Ceramide Methylaminoethylphosphonate

(2009) Madhavi Chintalapati et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sphingolipidomics: Methods for the comprehensive analysis of sphingolipids

(2009) Christopher A. Haynes et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of autophagy with cholesterol-accumulated compartments in Niemann-Pick disease type C cells

(2009) Seiya Ishibashi et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

(2009) T. Walker et al.   MOLECULAR PHARMACOLOGY

Lysosomal Storage Disorders in the Newborn

(2009) O. Staretz-Chacham et al.   PEDIATRICS

mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

(2009) E. Y. Chan   Science Signaling

The pathogenesis of Niemann–Pick type C disease: a role for autophagy?

(2008) Chris D. Pacheco et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

Nystatin Interferes with the Effects of N-Methyl-N′-nitro-N-nitrosoguanidine on Sphingolipid Metabolism in Human FL Cells

(2008) Guangyi Liu et al.   LIPIDS

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

(2008) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

(2008) Ayman EM Mahdy et al.   MOLECULAR THERAPY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE

Novel analogs of d-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids

(2007) Alicja Bielawska et al.   BIOORGANIC & MEDICINAL CHEMISTRY