Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Agephagy – Adapting Autophagy for Health During Aging

(2019) Eleanor R. Stead et al.   Frontiers in Cell and Developmental Biology

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy maintains stem cells and intestinal homeostasis in Drosophila

(2018) Péter Nagy et al.   Scientific Reports

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

(2017) Thomas Wilhelm et al.   GENES & DEVELOPMENT

Good Ol’ Fat: Links between Lipid Signaling and Longevity

(2017) Victor Bustos et al.   TRENDS IN BIOCHEMICAL SCIENCES

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Individual variability in human blood metabolites identifies age-related differences

(2016) Romanas Chaleckis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

(2016) Sveta Chakrabarti et al.   PLoS Genetics

Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants

(2016) Robert J. Shmookler Reis et al.   Aging-US

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Haemocytes control stem cell activity in the Drosophila intestine

(2015) Arshad Ayyaz et al.   NATURE CELL BIOLOGY

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Profiles and Signals for Long Life

(2015) Elizabeth A. Schroeder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Evolution of Atg1 function and regulation

(2014) Edmond Y. Chan et al.   Autophagy

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

The paradox of mitochondrial dysfunction and extended longevity

(2014) Erin Munkácsy et al.   EXPERIMENTAL GERONTOLOGY

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

Autophagy genes are required for normal lipid levels inC. elegans

(2013) Louis R. Lapierre et al.   Autophagy

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

(2013) Drew Stenesen et al.   Cell Metabolism

Reproduction, Fat Metabolism, and Life Span: What Is the Connection?

(2013) Malene Hansen et al.   Cell Metabolism

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: Role of autophagy

(2013) Xihui Xu et al.   JOURNAL OF HEPATOLOGY

A novel method for the identification of factors involved in host–pathogen interactions in Drosophila melanogaster

(2013) Beáta Kari et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Autophagy and ageing: Insights from invertebrate model organisms

(2012) Eirini Lionaki et al.   AGEING RESEARCH REVIEWS

The mystery of C. elegans aging: An emerging role for fat

(2012) Daniel Ackerman et al.   BIOESSAYS

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

(2012) Helena M Cochemé et al.   Nature Protocols

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A perspective on the determination of mitochondrial biogenesis

(2011) Benjamin F. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis

(2011) Richard A. Scheltema et al.   ANALYTICAL CHEMISTRY

Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction

(2011) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

(2011) Ivana Bjedov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

(2011) Helena M. Cochemé et al.   Cell Metabolism

Separating the wheat from the chaff: a prioritisation pipeline for the analysis of metabolomics datasets

(2011) Andris Jankevics et al.   Metabolomics

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis

(2010) J M I Barth et al.   CELL DEATH AND DIFFERENTIATION

Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila

(2010) Selim Terhzaz et al.   CELLULAR SIGNALLING

Does calorie restriction induce mitochondrial biogenesis? A reevaluation

(2010) Chad R. Hancock et al.   FASEB JOURNAL

A new DAF-16 isoform regulates longevity

(2010) Eun-Soo Kwon et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation

(2009) Yu-Yun Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Characterization of theDrosophilaGene-Switch system in aging studies: a cautionary tale

(2008) Luc Poirier et al.   AGING CELL

Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity

(2008) Chunli Ren et al.   EXPERIMENTAL GERONTOLOGY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction

(2007) Sergiy Libert et al.   MOLECULAR IMMUNOLOGY