Structure, kinetic properties and biological function of mechanosensitive Piezo channels

Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap

(2020) Amanda H. Lewis et al.   Cell Reports

The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism

(2020) Yanhua Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells

(2020) Kathrin Diem et al.   FASEB JOURNAL

YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation

(2020) Kana Hasegawa et al.   JOURNAL OF PATHOLOGY

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels

(2020) Jian Shi et al.   Cell Reports

Targeting Piezo1 unleashes innate immunity against cancer and infectious disease

(2020) Berk Aykut et al.   Science Immunology

A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels

(2019) Wang Zheng et al.   eLife

PIEZO1 Hypomorphic Variants in Congenital Lymphatic Dysplasia Cause Shape and Hydration Alterations of Red Blood Cells

(2019) Immacolata Andolfo et al.   Frontiers in Physiology

Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice

(2019) Mingmin Zhang et al.   Cell Reports

Dietary fatty acids fine-tune Piezo1 mechanical response

(2019) Luis O. Romero et al.   Nature Communications

Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer

(2019) Weiyang Lou et al.   Aging-US

Correction to: Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?

(2019) Gemma Mazzuoli-Weber et al.   CELL AND TISSUE RESEARCH

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

(2019) Nikita Mikhailov et al.   NEUROPHARMACOLOGY

Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

(2019) Andras Iring et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-guided examination of the mechanogating mechanism of PIEZO2

(2019) Francisco J. Taberner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIEZO1 Is Selectively Expressed in Small Diameter Mouse DRG Neurons Distinct From Neurons Strongly Expressing TRPV1

(2019) Jigong Wang et al.   Frontiers in Molecular Neuroscience

Advances of injectable hydrogel-based scaffolds for cartilage regeneration

(2019) Jiawei Li et al.   Regenerative Biomaterials

Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier

(2019) Ming Zhong et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Structure and mechanogating of the mammalian tactile channel PIEZO2

(2019) Li Wang et al.   NATURE

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Force-induced conformational changes in PIEZO1

(2019) Yi-Chih Lin et al.   NATURE

Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors

(2019) Wang Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Piezo1 attenuates demyelination in the central nervous system

(2019) María Velasco‐Estevez et al.   GLIA

A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1

(2019) Wesley M. Botello-Smith et al.   Nature Communications

The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation

(2019) Shinsuke Fujii et al.   LABORATORY INVESTIGATION

Piezo Ion Channels in Cardiovascular Mechanobiology

(2019) Dominique Douguet et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Piezo1 Cation Channel Mediates Uterine Artery Shear Stress Mechanotransduction and Vasodilation During Rat Pregnancy

(2018) Liam John et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation

(2018) Elizabeth L Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

Neural stem cells in neuropsychiatric disorders

(2018) Roberto Sacco et al.   CURRENT OPINION IN NEUROBIOLOGY

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

(2018) Yanfeng Wang et al.   Nature Communications

TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels

(2018) Evan O. Anderson et al.   Cell Reports

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

(2018) Julián Albarrán-Juárez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

(2018) Josefina Inés del Mármol et al.   eLife

Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

(2018) Hojin Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stretch-Activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries

(2018) Audrey Lhomme et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation

(2018) Keiko Nonomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

(2018) Wei-Zheng Zeng et al.   SCIENCE

PIEZO2 mediates injury-induced tactile pain in mice and humans

(2018) Marcin Szczot et al.   Science Translational Medicine

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

(2018) Swetha E. Murthy et al.   Science Translational Medicine

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

(2018) María Velasco-Estevez et al.   Frontiers in Aging Neuroscience

Piezo’s membrane footprint and its contribution to mechanosensitivity

(2018) Christoph A Haselwandter et al.   eLife

Mechanical Stimulation of Piezo1 Receptors Depends on Extracellular Matrix Proteins and Directionality of Force

(2017) Benjamin M. Gaub et al.   NANO LETTERS

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

(2017) Alice Arcourt et al.   NEURON

A protein interaction mechanism for suppressing the mechanosensitive Piezo channels

(2017) Tingxin Zhang et al.   Nature Communications

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

(2017) Baptiste Rode et al.   Nature Communications

Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction

(2017) Marcin Szczot et al.   Cell Reports

Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix

(2017) Jason Wu et al.   Cell Reports

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels

(2017) Virgilio L. Lew et al.   Frontiers in Physiology

Biallelic Loss of Proprioception-Related PIEZO2 Causes Muscular Atrophy with Perinatal Respiratory Distress, Arthrogryposis, and Scoliosis

(2016) Andrea Delle Vedove et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Complex morphology of gastrin-releasing G-cells in the antral region of the mouse stomach

(2016) Claudia Frick et al.   CELL AND TISSUE RESEARCH

Neural Stem Cell Transplantation and CNS Diseases

(2016) Rodolfo Gonzalez et al.   CNS & Neurological Disorders-Drug Targets

Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis

(2016) Isabel Spier et al.   Familial Cancer

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

(2016) Fan Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Piezo1 expression increases in rat bladder after partial bladder outlet obstruction

(2016) Mai Michishita et al.   LIFE SCIENCES

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

(2016) Keiko Nonomura et al.   NATURE

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Piezo1-dependent regulation of urinary osmolarity

(2016) Joana Raquel Martins et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

A family of distal arthrogryposis type 5 due to a novelPIEZO2mutation

(2015) Mariko Okubo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mechanotransduction's Impact on Animal Development, Evolution, and Tumorigenesis

(2015) Maria-Elena Fernandez-Sanchez et al.   Annual Review of Cell and Developmental Biology

Protonation of the Human PIEZO1 Ion Channel Stabilizes Inactivation

(2015) Chilman Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Piezo1 regulates mechanotransductive release of ATP from human RBCs

(2015) Eyup Cinar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocytes: Myelination and Axonal Support

(2015) Mikael Simons et al.   Cold Spring Harbor Perspectives in Biology

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis

(2015) Elisavet Fotiou et al.   Nature Communications

Piezo1 ion channel pore properties are dictated by C-terminal region

(2015) Bertrand Coste et al.   Nature Communications

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

(2015) Kevin Retailleau et al.   Cell Reports

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

(2015) Amanda H Lewis et al.   eLife

Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5

(2014) Margaret J. McMillin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional Role for Piezo1 in Stretch-evoked Ca2+Influx and ATP Release in Urothelial Cell Cultures

(2014) Tatsuya Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels

(2014) Nils R. Blumenthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct β Sandwich Fold

(2014) Aron Kamajaya et al.   STRUCTURE

Mechanics in Neuronal Development and Repair

(2013) Kristian Franze et al.   Annual Review of Biomedical Engineering

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1

(2013) I. Andolfo et al.   BLOOD

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

(2013) Rémi Peyronnet et al.   EMBO REPORTS

Piezo1 plays a role in erythrocyte volume homeostasis

(2013) A. Faucherre et al.   HAEMATOLOGICA

piezo2bRegulates Vertebrate Light Touch Response

(2013) Adèle Faucherre et al.   JOURNAL OF NEUROSCIENCE

Correction: Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain

(2013) Jizhe Hao et al.   NEURON

TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear

(2013) Bifeng Pan et al.   NEURON

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

(2013) C. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels

(2013) Juliette Albuisson et al.   Nature Communications

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

GTP-dependent run-up of Piezo2-type mechanically activated currents in rat dorsal root ganglion neurons

(2013) Zhanfeng Jia et al.   Molecular Brain

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

The mechanobiology of brain function

(2012) William J. Tyler   NATURE REVIEWS NEUROSCIENCE

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons

(2011) Cécile Hilaire et al.   BIOCHEMICAL JOURNAL

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood–brain barrier endothelial cells

(2011) Jonathan Berrout et al.   BRAIN RESEARCH

The DEG/ENaC Protein MEC-10 Regulates the Transduction Channel Complex in Caenorhabditis elegans Touch Receptor Neurons

(2011) J. Arnadottir et al.   JOURNAL OF NEUROSCIENCE

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

(2011) Stuart M. Brierley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

(2011) Shireen R Lamandé et al.   NATURE GENETICS

Molecular mechanisms of mechanotransduction in mammalian sensory neurons

(2011) Patrick Delmas et al.   NATURE REVIEWS NEUROSCIENCE

The emerging role of forces in axonal elongation

(2011) Daniel M. Suter et al.   PROGRESS IN NEUROBIOLOGY

Endothelium-derived Vasoactive Factors and Hypertension: Possible Roles in Pathogenesis and as Treatment Targets

(2010) Michel Félétou et al.   CURRENT HYPERTENSION REPORTS

The cell biology of touch

(2010) Ellen A. Lumpkin et al.   JOURNAL OF CELL BIOLOGY

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanosensitive gating of CFTR

(2010) Wei Kevin Zhang et al.   NATURE CELL BIOLOGY

C. elegans TRP Family Protein TRP-4 Is a Pore-Forming Subunit of a Native Mechanotransduction Channel

(2010) Lijun Kang et al.   NEURON

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Lysophosphatidyl choline modulates mechanosensitive L-type Ca2+ current in circular smooth muscle cells from human jejunum

(2009) Robert E. Kraichely et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Multifunctional rapidly adapting mechanosensitive enteric neurons (RAMEN) in the myenteric plexus of the guinea pig ileum

(2009) Gemma Mazzuoli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tuning the mechanosensitivity of a BK channel by changing the linker length

(2008) Hucheng Zhao et al.   CELL RESEARCH