The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

(2020) Yao Sun et al.   Journal of Neuroinflammation

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

(2020) Antonio Monaco et al.   MOLECULAR THERAPY

Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy

(2020) Seulgi Shin et al.   PROGRESS IN NEUROBIOLOGY

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

(2020) Shorena Janelidze et al.   Nature Communications

CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

(2020) Simon Hornung et al.   Frontiers in Molecular Neuroscience

Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age

(2020) Erden Eren et al.   Alzheimers & Dementia

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeting tau: Clinical trials and novel therapeutic approaches

(2020) Lawren VandeVrede et al.   NEUROSCIENCE LETTERS

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

(2020) Nora Bengoa-Vergniory et al.   Nature Communications

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

(2019) Ravinder Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

(2019) Clément Despres et al.   ACS Chemical Biology

The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy

(2019) Marcos Herrera-Vaquero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

(2019) Inesa Hadrovic et al.   Frontiers in Chemistry

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

(2019) Woo Shik Shin et al.   Alzheimers Research & Therapy

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation

(2019) Woo Shik Shin et al.   Frontiers in Molecular Neuroscience

Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer’s Disease

(2019) Celine Samaey et al.   Frontiers in Aging Neuroscience

Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer’s Disease: A Hypothesis

(2018) Shweta Kishor Sonawane et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

TOC1: Characterization of a Selective Oligomeric Tau Antibody

(2018) Sarah M. Ward et al.   JOURNAL OF ALZHEIMERS DISEASE

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

(2018) Michael Nshanian et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein

(2017) Franziska Richter et al.   Neurotherapeutics

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

(2017) Na Xu et al.   Journal of the American Heart Association

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

(2017) Maja Mustapic et al.   Frontiers in Neuroscience

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease

(2016) Min Shi et al.   Alzheimers & Dementia

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Molecular tweezers for lysine and arginine – powerful inhibitors of pathologic protein aggregation

(2016) Thomas Schrader et al.   CHEMICAL COMMUNICATIONS

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

(2016) Magdalena Przybyla et al.   NEUROSCIENCE LETTERS

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

(2016) Diana L. Castillo-Carranza et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism

(2015) Dahabada H. J. Lopes et al.   ACS Chemical Biology

Toxicity Inhibitors Protect Lipid Membranes from Disruption by Aβ42

(2015) Ravit Malishev et al.   ACS Chemical Neuroscience

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

(2015) Xueyun Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration

(2015) Janet van Eersel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Disrupting Self-Assembly and Toxicity of Amyloidogenic Protein Oligomers by “ Molecular Tweezers” - from the Test Tube to Animal Models

(2015) Aida Attar et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Tweezers Targeting Transthyretin Amyloidosis

(2014) Nelson Ferreira et al.   Neurotherapeutics

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity

(2014) Aida Attar et al.   BMC Pharmacology & Toxicology

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

(2013) Amy M Pooler et al.   Alzheimers Research & Therapy

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

(2012) A. Attar et al.   BRAIN

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice

(2012) Magali Dumont et al.   HUMAN MOLECULAR GENETICS

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition

(2008) Peter Talbiersky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates

(2008) G. Zamboni et al.   NEUROLOGY

A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition

(2007) Dorothy G. Flood et al.   NEUROBIOLOGY OF AGING