Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer’s Disease: A Hypothesis

Amyloid-β Metabolite Sensing: Biochemical Linking of Glycation Modification and Misfolding

(2018) Janelle N. Fawver et al.   JOURNAL OF ALZHEIMERS DISEASE

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

(2017) Masato Hasegawa et al.   PHARMACOLOGY & THERAPEUTICS

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

(2017) Samantha B. Nicholls et al.   PLoS One

How Does Hyperphopsphorylation Promote Tau Aggregation and Modulate Filament Structure and Stability?

(2016) Liang Xu et al.   ACS Chemical Neuroscience

Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property

(2016) Kefu Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

(2016) Sachin Suresh Tiwari et al.   BRAIN

Formation, release, and internalization of stable tau oligomers in cells

(2016) Susanne Wegmann et al.   JOURNAL OF NEUROCHEMISTRY

PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains

(2016) Eri Saijo et al.   JOURNAL OF VIROLOGY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

The Prion-Like Behavior of Assembled Tau in Transgenic Mice

(2016) Florence Clavaguera et al.   Cold Spring Harbor Perspectives in Medicine

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

(2016) Ksenia Kurbatskaya et al.   Acta Neuropathologica Communications

Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII

(2015) Yan Wei et al.   AGING CELL

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Therapeutic Mechanisms of Tau Antibodies

(2015) Kristen E. Funk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

(2015) Lixin Song et al.   Molecular Neurodegeneration

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Tau immunization: a cautionary tale?

(2015) Alexandra J. Mably et al.   NEUROBIOLOGY OF AGING

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Glyceraldehyde caused Alzheimer’s disease-like alterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells

(2015) Yoshiki Koriyama et al.   Scientific Reports

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of phosphoproteome in RAGE signaling

(2014) Kedar B. Batkulwar et al.   PROTEOMICS

Role of advanced glycation end products in cellular signaling

(2014) Christiane Ott et al.   Redox Biology

The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes

(2014) Cristian A Lasagna-Reeves et al.   Acta Neuropathologica Communications

A Double-Blind, Placebo-Controlled, Ascending-Dose, Randomized Study to Evaluate the Safety, Tolerability and Effects on Cognition of AL-108 after 12 Weeks of Intranasal Administration in Subjects with Mild Cognitive Impairment

(2013) Bruce H. Morimoto et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties

(2013) Enrico Cancellotti et al.   EMBO JOURNAL

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

(2013) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome release from infected dendritic cells: A clue for a fast spread of prions in the periphery?

(2013) Peter-Christian Klöhn et al.   JOURNAL OF INFECTION

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates

(2012) Ilan Margalith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunotherapy in prion disease

(2012) Yvonne Roettger et al.   Nature Reviews Neurology

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Monoclonal Antibodies Specific for Glycated Prion Protein

(2011) Eva Dvorakova et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Immunotherapy for prion diseases: opportunities and obstacles

(2010) Li Li et al.   Immunotherapy

Phosphorylation of Tau at Thr212, Thr231, and Ser262Combined Causes Neurodegeneration

(2010) Alejandra D. Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosylation of PrPC Determines Timing of Neuroinvasion and Targeting in the Brain following Transmissible Spongiform Encephalopathy Infection by a Peripheral Route

(2010) E. Cancellotti et al.   JOURNAL OF VIROLOGY

‘Prion-Like’ Propagation of Mouse and Human Tau Aggregates in an Inducible Mouse Model of Tauopathy

(2010) Astrid Sydow et al.   Neurodegenerative Diseases

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

(2009) Bruno Bulic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics

(2008) Adria C. LeBoeuf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY