Molecular Tweezers Targeting Transthyretin Amyloidosis

Molecular Tweezers with Varying Anions: A Comparative Study

(2013) Som Dutt et al.   JOURNAL OF ORGANIC CHEMISTRY

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular tweezers modulate 14-3-3 protein–protein interactions

(2013) David Bier et al.   Nature Chemistry

A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

(2012) A. Attar et al.   BRAIN

Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin

(2012) Maria Rosário Almeida et al.   FEBS LETTERS

Tafamidis

(2012) Gerard Said et al.   NATURE REVIEWS DRUG DISCOVERY

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

Epigallocatechin-3-Gallate as a Potential Therapeutic Drug for TTR-Related Amyloidosis: “In Vivo” Evidence from FAP Mice Models

(2012) Nelson Ferreira et al.   PLoS One

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (−)-Epigallocatechin-3-gallate

(2010) Shi-Hui Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity

(2009) Nelson Ferreira et al.   FEBS LETTERS

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

(2009) Orly Weinreb et al.   Genes and Nutrition

Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy

(2008) Bárbara Macedo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases

(2008) Silvia A. Mandel et al.   CNS Neuroscience & Therapeutics

Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition

(2008) Peter Talbiersky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems

(2008) Sofia Duque Santos et al.   NEUROBIOLOGY OF AGING