The Roles of Integrin α5β1 in Human Cancer

Alternative splicing of Ikaros regulates the FUT4/LeX-α5β1 integrin-FAK axis in acute lymphoblastic leukemia

(2019) Lijun Yi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

(2019) Minhong Shen et al.   CANCER CELL

c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow

(2019) Bochuan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Improved in vivo Targeting Capability and Pharmacokinetics of 99mTc-labeled isoDGR by Dimerization and Albumin-Binding for Glioma imaging

(2019) Hannan Gao et al.   BIOCONJUGATE CHEMISTRY

Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

(2019) Swechha M. Pokharel et al.   Nature Communications

RNA aptamers targeting integrin α5β1 as probes for cyto- and histo-fluorescence in glioblastoma

(2019) P. Fechter et al.   Molecular Therapy-Nucleic Acids

Autocrine Production of PDGF Stimulated by the Tenascin-C-Derived Peptide TNIIIA2 Induces Hyper-Proliferation in Glioblastoma Cells

(2019) Motomichi Fujita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CKAP4 Regulates Cell Migration via the Interaction with and Recycling of Integrin

(2019) Yoshihito Osugi et al.   MOLECULAR AND CELLULAR BIOLOGY

ATN-161 reduces virus proliferation in PHEV-infected mice by inhibiting the integrin α5β1-FAK signaling pathway

(2019) Xiaoling Lv et al.   VETERINARY MICROBIOLOGY

Functional identification and characterization of the nuclear egress complex of a gammaherpesvirus

(2019) Ying Lv et al.   JOURNAL OF VIROLOGY

Integrin-EGFR interaction regulates anoikis resistance in colon cancer cells

(2019) Deblina Guha et al.   APOPTOSIS

EWS-FLI1-mediated tenascin-C expression promotes tumour progression by targeting MALAT1 through integrin α5β1-mediated YAP activation in Ewing sarcoma

(2019) Shaohui He et al.   BRITISH JOURNAL OF CANCER

Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis

(2019) Sanguk Yun et al.   JOURNAL OF CLINICAL INVESTIGATION

Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions

(2019) Rattila et al.   Cells

The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis

(2019) Wen-Ye Tjong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

αvβ3 and α5β1 integrin-specific ligands: From tumor angiogenesis inhibitors to vascularization promoters in regenerative medicine?

(2018) Luís A. Rocha et al.   BIOTECHNOLOGY ADVANCES

Phase I study of the anti-α5β1 monoclonal antibody MINT1526A with or without bevacizumab in patients with advanced solid tumors

(2018) Colin D. Weekes et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress

(2018) Meng Lu et al.   HEPATOLOGY

Native and recombinant phospholipases A 2 of Scorpio maurus venom glands impair angiogenesis by targeting integrins α5β1 and αvβ3

(2018) Najeh Krayem et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration

(2018) Nicole L. Diggins et al.   JOURNAL OF CELL SCIENCE

Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

(2018) Ruixia Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma

(2018) François Kuonen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent

(2018) Tobias G. Kapp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of aptamers for in vivo molecular imaging and theranostics

(2018) Alix Bouvier-Müller et al.   ADVANCED DRUG DELIVERY REVIEWS

EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors

(2018) Nevenka Dudvarski Stanković et al.   EMBO Molecular Medicine

Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation

(2018) Zaki Al-Yafeai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-1β promotes transendothelial migration of PBMCs by upregulation of the FN/α5β1 signalling pathway in immortalised human brain microvascular endothelial cells

(2018) Josephine Labus et al.   EXPERIMENTAL CELL RESEARCH

CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17

(2018) Yesenia Machado-Pineda et al.   Frontiers in Immunology

A Key Regulator of Cell Adhesion: Identification and Characterization of Important N -Glycosylation Sites on Integrin α5 for Cell Migration

(2017) Qinglei Hang et al.   MOLECULAR AND CELLULAR BIOLOGY

The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin α5β1/ERK/Runx2 pathway

(2017) Sin-Hye Oh et al.   PLoS One

Extracellular matrix and α5β1 integrin signaling control the maintenance of bone formation capacity by human adipose-derived stromal cells

(2017) Nunzia Di Maggio et al.   Scientific Reports

Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth

(2017) H J Nakaoka et al.   Oncogenesis

Exploring the Role of RGD-Recognizing Integrins in Cancer

(2017) Markus Nieberler et al.   Cancers

The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation

(2017) Xiulei Cai et al.   Scientific Reports

99mTc-HisoDGR as a Potential SPECT Probe for Orthotopic Glioma Detection via Targeting of Integrin α5β1

(2016) Haitao Zhao et al.   BIOCONJUGATE CHEMISTRY

YAP/TAZ as therapeutic targets in cancer

(2016) Francesca Zanconato et al.   CURRENT OPINION IN PHARMACOLOGY

RGD-based Therapy: Principles of Selectivity

(2016) Mikhail A. Rubtsov et al.   CURRENT PHARMACEUTICAL DESIGN

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1

(2016) Cheng Gong et al.   ONCOLOGY REPORTS

The Interaction of CD154 with the α5β1 Integrin Inhibits Fas-Induced T Cell Death

(2016) Meriem Bachsais et al.   PLoS One

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

(2016) Giulia Mana et al.   Nature Communications

Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3

(2016) Liang Lin et al.   Oncotarget

Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells

(2016) Guillaume Renner et al.   Oncotarget

The modulation of MiR-155 and MiR-23a manipulates Klebsiella pneumoniae Adhesion on Human pulmonary Epithelial cells via Integrin α5β1 Signaling

(2016) Yan Teng et al.   Scientific Reports

N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4

(2016) Qinglei Hang et al.   Scientific Reports

Integrin α5β1 simultaneously controls EGFR-dependent proliferation and Akt-dependent pro-survival signaling in epidermoid carcinoma cells

(2016) Galina E Morozevich et al.   Aging-US

Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma

(2015) G Renner et al.   CELL DEATH AND DIFFERENTIATION

 5 and  v integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo

(2015) C. J. Turner et al.   DEVELOPMENT

In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366

(2015) Calogero D’Alessandria et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma

(2015) M Bosnjak et al.   GENE THERAPY

Predictive markers of chemoresistance in advanced stages epithelial ovarian carcinoma

(2015) Claire Bonneau et al.   GYNECOLOGIC ONCOLOGY

Wnt/β-Catenin Signaling Mediates Osteoblast Differentiation Triggered by Peptide-induced α5β1 Integrin Priming in Mesenchymal Skeletal Cells

(2015) Zuzana Saidak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

(2015) Nikki R. Paul et al.   JOURNAL OF CELL BIOLOGY

The specifical inhibition of the expression of integrin alpha5/beta1 probably enhances the treatment effects and improves the prognosis of epithelial ovarian cancer

(2015) Xiaoyan Xie et al.   MEDICAL HYPOTHESES

Integrins and haptoglobin: Molecules overexpressed in ovarian cancer

(2015) Julio César Villegas-Pineda et al.   PATHOLOGY RESEARCH AND PRACTICE

Alpha2beta1 integrin in cancer development and chemoresistance

(2015) Dalila Naci et al.   SEMINARS IN CANCER BIOLOGY

CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and fibronectin-enriched matrices

(2015) Suzanne McFarlane et al.   Oncotarget

Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties

(2015) Alain C. Jung et al.   Oncotarget

Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors

(2015) Patrick A. Murphy et al.   PLoS One

A d-amino acid containing peptide as a potent, noncovalent inhibitor of α5β1 integrin in human prostate cancer invasion and lung colonization

(2014) Donna M. Veine et al.   CLINICAL & EXPERIMENTAL METASTASIS

Gln-362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with α5β1 Integrin

(2014) Hyo Seon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increasing Cancer-Specific Gene Expression by Targeting Overexpressed α5β1 Integrin and Upregulated Transcriptional Activity of NF-κB

(2014) Maroof M. Adil et al.   MOLECULAR PHARMACEUTICS

MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis

(2014) S-H Chan et al.   ONCOGENE

CD9 Negatively Regulates CD26 Expression and Inhibits CD26-Mediated Enhancement of Invasive Potential of Malignant Mesothelioma Cells

(2014) Toshihiro Okamoto et al.   PLoS One

Role of integrins and their ligands in osteoarthritic cartilage

(2014) Jian Tian et al.   RHEUMATOLOGY INTERNATIONAL

The Secreted Protein ANGPTL2 Promotes Metastasis of Osteosarcoma Cells Through Integrin  5 1, p38 MAPK, and Matrix Metalloproteinases

(2014) H. Odagiri et al.   Science Signaling

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3

(2013) Stefanie Neubauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prognostic Significance of α5β1-integrin Expression in Cervical Cancer

(2013) Hua-Yi Wang et al.   Asian Pacific Journal of Cancer Prevention

Integrin α5β1-fimbriae binding and actin rearrangement are essential for Porphyromonas gingivalis invasion of osteoblasts and subsequent activation of the JNK pathway

(2013) Wenjian Zhang et al.   BMC MICROBIOLOGY

Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells

(2013) Hana Janouskova et al.   CANCER LETTERS

Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial  5 Integrin

(2013) Y. Cao et al.   CANCER RESEARCH

CCN2 promotes keratinocyte adhesion and migration via integrin α5β1

(2013) Elizabeth Kiwanuka et al.   EXPERIMENTAL CELL RESEARCH

Clinical Implications of CSN6 Protein Expression and Correlation with Mutant-type P53 Protein in Breast Cancer

(2013) W. Wang et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

RhoC Interacts with Integrin α5β1 and Enhances Its Trafficking in Migrating Pancreatic Carcinoma Cells

(2013) Ningfeng Fiona Li et al.   PLoS One

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

(2013) Florence Schaffner et al.   Cancers

Phase Ib safety and pharmacokinetic study of volociximab, an anti-α5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer

(2012) B. Besse et al.   ANNALS OF ONCOLOGY

Modulation of MMPs by Cell Surface Integrin Receptor α5β1

(2012) Sekhar Pal et al.   Anti-Cancer Agents in Medicinal Chemistry

HMGB-1 induces cell motility and α5β1 integrin expression in human chondrosarcoma cells

(2012) Chih-Hsin Tang et al.   CANCER LETTERS

Integrin  5 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

(2012) H. Janouskova et al.   CANCER RESEARCH

Neuropilin-1Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor Microenvironment

(2012) Usman Yaqoob et al.   CANCER RESEARCH

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia

(2012) Longxuan Li et al.   EXPERIMENTAL NEUROLOGY

Elevated Levels of Lewis Y and Integrin α5β1 Correlate with Chemotherapeutic Drug Resistance in Epithelial Ovarian Carcinoma

(2012) Zhenhua Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Periostin activates integrin α5β1 through a PI3K/AKT-dependent pathway in invasion of cholangiocarcinoma

(2012) KUSUMAWADEE UTISPAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Epidermal Growth Factor (EGF) Regulates α5β1 Integrin Activation State in Human Cancer Cell Lines through the p90RSK-dependent Phosphorylation of Filamin A

(2012) Daniel Vial et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function and localization in epithelial cells

(2012) K Mythreye et al.   ONCOGENE

Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling

(2011) Vermont P. Dia et al.   CANCER LETTERS

Integrin α5β1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity

(2011) Galina Morozevich et al.   CELL CYCLE

Integrin α3β1 as a breast cancer target

(2011) Sita Subbaram et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

Involvement of the TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma

(2011) Erika C. Cosset et al.   INTERNATIONAL JOURNAL OF CANCER

Integrin  5 1 facilitates cancer cell invasion through enhanced contractile forces

(2011) C. T. Mierke et al.   JOURNAL OF CELL SCIENCE

H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis

(2011) Yi-Chun Yeh et al.   MOLECULAR CARCINOGENESIS

Fibronectin-Integrin (α5β1) Modulates Migration and Invasion of Murine Melanoma Cell Line B16F10 by Involving MMP-9

(2011) Hrishikesh Sil et al.   ONCOLOGY RESEARCH

Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines

(2011) Solange Landreville et al.   Pigment Cell & Melanoma Research

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin  5 1 and Fibronectin

(2010) J.-M. Nam et al.   CANCER RESEARCH

TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin  5 and its signaling pathways

(2010) S. Kim et al.   CARCINOGENESIS

Endothelial  5 and  v integrins cooperate in remodeling of the vasculature during development

(2010) A. van der Flier et al.   DEVELOPMENT

Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes

(2010) Viola Hélène Lobert et al.   DEVELOPMENTAL CELL

α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells

(2010) Eva Martinkova et al.   INTERNATIONAL JOURNAL OF CANCER

ADAM15 to α5β1 integrin switch in colon carcinoma cells: A late event in cancer progression associated with tumor dedifferentiation and poor prognosis

(2010) Claire Toquet et al.   INTERNATIONAL JOURNAL OF CANCER

Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis

(2010) A K Mitra et al.   ONCOGENE

A New α5β1 Integrin-Dependent Survival Pathway Through GSK3β Activation in Leukemic Cells

(2010) Fabienne De Toni-Costes et al.   PLoS One

α5β1 Integrin Blockade Inhibits Lymphangiogenesis in Airway Inflammation

(2009) Tatsuma Okazaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Importance of N-Glycosylation on α5β1 Integrin for Its Biological Functions

(2009) Jianguo Gu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion

(2009) X N Meng et al.   BRITISH JOURNAL OF CANCER

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Vesicle-associated membrane protein 2 mediates trafficking of α5β1 integrin to the plasma membrane

(2009) Nazarul Hasan et al.   EXPERIMENTAL CELL RESEARCH

N-Glycosylation of the I-like Domain of β1 Integrin Is Essential for β1 Integrin Expression and Biological Function

(2009) Tomoya Isaji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computer Aided Identification of Small Molecules Disrupting uPAR/α5β1- Integrin Interaction: A New Paradigm for Metastasis Prevention

(2009) Pratima Chaurasia et al.   PLoS One

Caveolin-1 regulates glioblastoma aggressiveness through the control of α5β1 integrin expression and modulates glioblastoma responsiveness to SJ749, an α5β1 integrin antagonist

(2008) Sophie Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via  5-Integrin, which Is a Therapeutic Target

(2008) K. Sawada et al.   CANCER RESEARCH

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH