Article
Oncology
Xu Yang, Lihua Yang, Annie Luo, Shanshan Liu, Xiaohong Zhang, Xiaoping Liu, Xiaodan Liu, Ailing Luo, Mansi Cai, Yaping Yan, Xuedong Wu, Ke Huang, Ling Xu, Hua Jiang
Summary: This study revealed an association between IKZF3 gene polymorphisms and increased susceptibility to childhood ALL, suggesting the potential use of IKZF3 polymorphisms as a biomarker for this disease.
Article
Biochemistry & Molecular Biology
Elanora Dovat, Chunhua Song, Tommy Hu, Mohammad Atiqur Rahman, Pavan Kumar Dhanyamraju, Morgann Klink, Daniel Bogush, Mario Soliman, Shriya Kane, Mary McGrath, Yali Ding, Dhimant Desai, Arati Sharma, Chandrika Gowda
Summary: IKAROS, encoded by the IKZF1 gene, acts as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL) by regulating the transcription of PIK3CD and PIKFYVE. On the other hand, CK2, a pro-oncogenic kinase, impairs IKAROS function and contributes to the upregulation of the PI3K signaling pathway in T-ALL. Inhibition of CK2 restores IKAROS's regulatory effects on the PI3K oncogenic signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Signe Modvig, Jenani Jeyakumar, Hanne Vibeke Marquart, Claus Christensen
Summary: The central nervous system is a restricted microenvironment where immune cells and some cancers can enter. Integrins, a family of adhesion molecules, are studied in both normal immune cells and cancer cells. This review examines if the same integrins are used by different cell types entering the central nervous system, providing ideas for future cancer research.
Article
Oncology
Wenxiang Sun, Jingtao Guo, David McClellan, Alexandra Poeschla, Diana Bareyan, Mattie J. Casey, Bradley R. Cairns, Dean Tantin, Michael E. Engel
Summary: GFI1 and IKAROS cooperate to regulate the expression of hallmark T-cell development genes in T-acute lymphoblastic leukemia (ALL) cells. NOTCH3, a key factor in T-ALL pathogenesis, is transactivated by GFI1 and IKAROS. The SNAG domain of GFI1 plays an important role in this process.
MOLECULAR CANCER RESEARCH
(2022)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Biophysics
Sebastian Giebel, Myriam Labopin, Gerard Socie, David Beauvais, Stefan Klein, Eva Maria Wagner-Drouet, Didier Blaise, Stephanie Nguyen-Quoc, Jean Henri Bourhis, Anne Thiebaut, Helene Labussiere-Wallet, Amandine Charbonnier, Ana Berceanu, Jose Luis Diez-Martin, Nathalie Fegueux, Jordi Esteve, Arnon Nagler, Mohamad Mohty
Summary: The presence of IKZF1 gene mutations is associated with poor prognosis of BCP-ALL. Patients undergoing allo-HCT have relatively good survival rates, but those with positive MRD status have a poorer prognosis.
BONE MARROW TRANSPLANTATION
(2021)
Review
Hematology
Shyam Srinivasan, Subramaniam Ramanathan, Shathish Kumar, Srinivasan Peyam, Venkatraman Radhakrishnan
Summary: IKZF1 alteration is an essential regulator in childhood acute lymphoblastic leukemia with negative impact on prognosis. This meta-analysis examines the prevalence and prognostic significance of IKZF1 deletion in childhood ALL and highlights its association with poor survival outcomes.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Hiroyuki Kimura, Masahiro Onozawa, Shota Yoshida, Naoki Miyashita, Shota Yokoyama, Toshihiro Matsukawa, Shinsuke Hirabayashi, Hideki Goto, Tomoyuki Endo, Satoshi Oguri, Shinichi Fujisawa, Akio Mori, Takeshi Kondo, Daisuke Hidaka, Kohei Okada, Shuichi Ota, Yasutaka Kakinoki, Yutaka Tsutsumi, Satoshi Yamamoto, Takuto Miyagishima, Junichi Hashiguchi, Takahiro Nagashima, Makoto Ibata, Kentaro Wakasa, Yoshihito Haseyama, Katsuya Fujimoto, Toshimichi Ishihara, Hajime Sakai, Takanori Teshima
Summary: IKZF1 deletion is a common genomic alteration in B-cell acute lymphoblastic leukemia (B-ALL), which can be categorized into dominant-negative (DN) and loss of function (LOF) deletions. A retrospective analysis of 117 adult B-ALL patients revealed that the specific type of deletion impacts the prognosis. Patients with at least one allele of increment 4-7 belonged to the DN group, and they exhibited significantly higher overall survival than the LOF and wildtype (WT) groups.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Christina Karantanou, Valentina R. Minciacchi, Rahul Kumar, Costanza Zanetti, Jimena Bravo, Raquel S. Pereira, Georg Tascher, Tobias Tertel, Adriana Covarrubias-Pinto, Katrin Bankov, Lisa -Marie Pfeffermann, Halvard Bonig, Paola Divieti-Pajevic, David G. McEwan, Bernd Giebel, Christian Muench, Ivan Dikic, Daniela S. Krause
Summary: Leukemia cells interact with their surrounding bone marrow microenvironment through the release of small extracellular vesicles (sEVs), promoting leukemia cell survival. However, the deficiency of PLEKHM1 in the bone marrow microenvironment accelerates BCR-ABL1+ B-cell acute lymphoblastic leukemia (B-ALL) by affecting the cargo of sEVs released by mesenchymal stromal cells (MSCs) derived from the bone marrow. PLEKHM1-deficient MSCs and their sEVs carry increased amounts of syntenin and syndecan-1, leading to immature B-cell phenotype and enhanced leukemia-initiating cell (LIC) function in B-ALL. In addition, inflammatory cytokines secreted by cancer cells modulate the tumor microenvironment, further perpetuating the sEV-associated circuit.
Article
Oncology
Sanjeev Kumar Gupta, Sameer Bakhshi, Ritu Gupta, Preity Sharma, Deepam Pushpam, Ranjit Kumar Sahoo, Vineet Kumar Kamal
Summary: IKZF1 deletions were found in 14.7% of BCR-ABL1-negative pediatric B-ALL cases, with the loss-of-function type being the predominant subtype. Cases with loss-of-function deletions had lower remission rates and poor event-free survival and overall survival compared to cases without IKZF1 deletions.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2021)
Article
Pharmacology & Pharmacy
Shuang Fu, Mengqi Li, Hongtao Wang
Summary: This article describes a rare case of a 29-year-old man diagnosed with acute promyelocytic leukemia (APL) in 2019, who developed BCR-ABL1-positive acute lymphoblastic leukemia (ALL) 2 years later. The patient responded well to tyrosine kinase inhibitors and chemotherapy, achieving a molecular remission. While APL generally has a good prognosis, the prognosis of its secondary malignancies is uncertain. There are no effective measures to prevent the occurrence of secondary tumors. Increasing the frequency of laboratory testing, especially molecular biomarker monitoring, is crucial for diagnosing and treating secondary malignancies after achieving complete remission.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Zixi Hong, Zimeng Wei, Tian Xie, Lin Fu, Jiaxing Sun, Fuling Zhou, Muhammad Jamal, Qiuping Zhang, Liang Shao
Summary: Acute lymphoblastic leukemia (ALL) is regulated by various signaling molecules such as cytokines and adhesion molecules in its microenvironment. Chemokines play important roles in leukemia microenvironment and affect ALL outcomes. Targeting chemokine axes for ALL treatments shows potential, with some related inhibitors entering clinical trials.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Cell Biology
Constantin Blochl, Di Wang, Katarina Madunic, Guinevere S. M. Lageveen-Kammeijer, Christian G. Huber, Manfred Wuhrer, Tao Zhang
Summary: AML presents challenges in treatment due to high rates of relapse or refractory disease. Recent studies have highlighted the importance of protein glycosylation in AML pathobiology, with specific glycan epitopes linked to disease outcome. This exploratory glycomics study identified distinct glycan structures in AML cell lines, providing insights into potential drivers of glycan phenotype.
Review
Pediatrics
Luke Maese, Rachel E. Rau
Summary: Cure rates for pediatric acute lymphoblastic leukemia (ALL) have significantly improved in the past five decades, largely due to the development and understanding of combination chemotherapy. Asparaginase, a recent addition to ALL chemotherapy, plays a crucial role in therapy by depleting the essential amino acid asparagine. Its unique toxicity profile, including hypersensitivity reactions, and the need for therapeutic drug monitoring have influenced the incorporation of asparaginase into ALL treatment. Despite its long-term use and standard-of-care status, there is still room for further improvement in the utilization of asparaginase therapy.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Diana Karen Mendiola-Soto, Diego Alberto Barcenas-Lopez, Carlos Jhovani Perez-Amado, Gabriela Marisol Cruz-Miranda, Juan Manuel Mejia-Arangure, Julian Ramirez-Bello, Alfredo Hidalgo-Miranda, Silvia Jimenez-Morales
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, and although cure rates have increased, a significant number of patients still relapse. The role of microRNAs (miRNAs) as non-coding RNA genes in ALL has gained interest in terms of understanding the disease's molecular mechanisms and identifying clinical biomarkers. Consistent findings suggest that miRNAs can be useful in distinguishing between different types of leukemia and predicting chemotherapy response. However, there is limited research on the molecular interplay between miRNAs and their targeted genes. This review aims to discuss the various ways miRNAs could be involved in ALL and their clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)