α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration

Expression of APPL1 is correlated with clinicopathologic characteristics and poor prognosis in patients with gastric cancer

(2016) J.S. Zhai et al.   Current Oncology

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer

(2016) Ali Jason Saleh et al.   TUMOR BIOLOGY

On the move: endocytic trafficking in cell migration

(2015) Tanja Maritzen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endocytic Trafficking of Integrins in Cell Migration

(2015) Nikki R. Paul et al.   CURRENT BIOLOGY

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

(2015) Inna Kalaidzidis et al.   JOURNAL OF CELL BIOLOGY

Appl1andAppl2are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts

(2015) Yinfei Tan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

On the Role of Rab5 in Cell Migration

(2014) P. Mendoza et al.   CURRENT MOLECULAR MEDICINE

The Arf6 GTPase-activating Proteins ARAP2 and ACAP1 Define Distinct Endosomal Compartments That Regulate Integrin α5β1 Traffic

(2014) Pei-Wen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion

(2014) J. Diaz et al.   JOURNAL OF CELL SCIENCE

Altered Endosome Biogenesis in Prostate Cancer Has Biomarker Potential

(2014) I. R. D. Johnson et al.   MOLECULAR CANCER RESEARCH

Quantitative and unbiased analysis of directional persistence in cell migration

(2014) Roman Gorelik et al.   Nature Protocols

Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways

(2014) Ludovic Ménard et al.   Nature Communications

The Rho family GEF Asef2 regulates cell migration in three dimensional (3D) collagen matrices through myosin II

(2014) Léolène Jean et al.   Cell Adhesion & Migration

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

(2014) Jiyoon Ryu et al.   Cell Reports

Role of adhesion receptor trafficking in 3D cell migration

(2013) Guillaume Jacquemet et al.   CURRENT OPINION IN CELL BIOLOGY

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex

(2013) Guillaume Jacquemet et al.   JOURNAL OF CELL BIOLOGY

PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth

(2013) M. Santiago-Medina et al.   JOURNAL OF CELL SCIENCE

Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells

(2013) P. Mendoza et al.   JOURNAL OF CELL SCIENCE

PKB/Akt-Dependent Regulation of Cell Motility

(2013) G. Xue et al.   JNCI-Journal of the National Cancer Institute

Reconstruction of an Integrated Genome-Scale Co-Expression Network Reveals Key Modules Involved in Lung Adenocarcinoma

(2013) Gholamreza Bidkhori et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling

(2012) Chiara Sandri et al.   CELL RESEARCH

Distinct Roles of Talin and Kindlin in Regulating Integrin α5β1 Function and Trafficking

(2012) Coert Margadant et al.   CURRENT BIOLOGY

Assembly and disassembly of cell matrix adhesions

(2012) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

Rab5 in the Regulation of Cell Motility and Invasion

(2012) Dwayne G. Stupack et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

PKD Controls αvβ3 Integrin Recycling and Tumor Cell Invasive Migration through Its Substrate Rabaptin-5

(2012) Claudine Christoforides et al.   DEVELOPMENTAL CELL

Cell Adhesion and Its Endocytic Regulation in Cell Migration during Neural Development and Cancer Metastasis

(2012) Takeshi Kawauchi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

(2012) Florian Steinberg et al.   JOURNAL OF CELL BIOLOGY

The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration

(2012) Joshua A. Broussard et al.   MOLECULAR BIOLOGY OF THE CELL

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

The PDZ Protein GIPC Regulates Trafficking of the LPA1 Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

(2012) Tal Varsano et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Endothelial Cell Migration on Fibronectin Is Regulated by Syntaxin 6-mediated α5β1 Integrin Recycling

(2011) Ajit Tiwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration

(2011) Violaine D. Delorme-Walker et al.   JOURNAL OF CELL BIOLOGY

Adhesion dynamics at a glance

(2011) M. Vicente-Manzanares et al.   JOURNAL OF CELL SCIENCE

Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes

(2010) Viola Hélène Lobert et al.   DEVELOPMENTAL CELL

APPL Proteins FRET at the BAR: Direct Observation of APPL1 and APPL2 BAR Domain-Mediated Interactions on Cell Membranes Using FRET Microscopy

(2010) Heidi J. Chial et al.   PLoS One

Appl1Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts

(2009) Yinfei Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal Adaptor Proteins APPL1 and APPL2 Are Novel Activators of β-Catenin/TCF-mediated Transcription

(2009) Sajid Rashid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration

(2009) Jeanne M. Bristow et al.   JOURNAL OF CELL SCIENCE

Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis

(2009) Vicente A. Torres et al.   MOLECULAR BIOLOGY OF THE CELL

Endocytosis and spatial restriction of cell signaling

(2009) Andrea Disanza et al.   Molecular Oncology

Photoactivatable mCherry for high-resolution two-color fluorescence microscopy

(2009) Fedor V Subach et al.   NATURE METHODS

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

APPL1: role in adiponectin signaling and beyond

(2008) Sathyaseelan S. Deepa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction

(2008) Makoto Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration

(2008) Andrea Palamidessi et al.   CELL

Asymmetric focal adhesion disassembly in motile cells

(2008) Joshua A Broussard et al.   CURRENT OPINION IN CELL BIOLOGY

Caveolin-1-dependent  1 integrin endocytosis is a critical regulator of fibronectin turnover

(2008) F. Shi et al.   JOURNAL OF CELL SCIENCE

Endocytosis and Cancer: an ‘Insider’ Network with Dangerous Liaisons

(2008) Letizia Lanzetti et al.   TRAFFIC

Cell–matrix adhesion complexes: Master control machinery of cell migration

(2007) John G. Lock et al.   SEMINARS IN CANCER BIOLOGY