Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

Codonopsis lanceolata polysaccharide CLPS inhibits melanoma metastasis via regulating integrin signaling

(2017) Yanqiu Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts

(2017) Ruixia Huang et al.   Journal of Translational Medicine

Altered integrin expression patterns shown by microarray in human cutaneous melanoma

(2017) Laura Vizkeleti et al.   MELANOMA RESEARCH

ATN-161 Peptide Functionalized Reversibly Cross-Linked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice

(2017) Ning Zhang et al.   MOLECULAR PHARMACEUTICS

The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human α V β 3 Integrin via Steric Hindrance

(2017) Andrew J. Borst et al.   STRUCTURE

Melanoma complicating treatment with natalizumab for multiple sclerosis: A report from the Southern Network on Adverse Reactions (SONAR)

(2017) Rachel A. Sabol et al.   Cancer Medicine

Integrins and Exosomes, a Dangerous Liaison in Cancer Progression

(2017) et al.   Cancers

Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis

(2017) Katrin Echtler et al.   PLoS One

Integrin α4 Induces Lymphangiogenesis and Metastasis via Upregulation of VEGF-C in Human Colon Cancer

(2016) Xiao-Hong Lv et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

Targeting αvβ3 and αvβ5 integrins inhibits pulmonary metastasis in an intratibial xenograft osteosarcoma mouse model

(2016) Ana Gvozdenovic et al.   Oncotarget

VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers

(2016) Rubén A. Bartolomé et al.   Oncotarget

Research advances on structure and biological functions of integrins

(2016) Li Pan et al.   SpringerPlus

Organ-seeking vesicles

(2015) Janusz Rak   NATURE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Orally active αvβ3 integrin inhibitor MK-0429 reduces melanoma metastasis

(2015) MAUREEN PICKARSKI et al.   ONCOLOGY REPORTS

Constitutive Expression of the α4 Integrin Correlates with Tumorigenicity and Lymph Node Metastasis of the B16 Murine Melanoma

(2015) Robert B. Rebhun et al.   NEOPLASIA

A first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors

(2014) J. Mateo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

αvβ3, αvβ5 and αvβ6 integrins in brain metastases of lung cancer

(2014) Anna Sophie Berghoff et al.   CLINICAL & EXPERIMENTAL METASTASIS

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Investigating the metastatic niche in melanoma: a new therapeutic opportunity?

(2014) Ewa Aladowicz et al.   Future Oncology

Cilengitide downmodulates invasiveness and vasculogenic mimicry of neuropilin 1 expressing melanoma cells through the inhibition of αvβ5 integrin

(2014) Federica Ruffini et al.   INTERNATIONAL JOURNAL OF CANCER

Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells

(2014) Y T Hsieh et al.   LEUKEMIA

Melanoma epidemiology, biology and prognosis

(2013) Z. Ali et al.   EJC SUPPLEMENTS

αv-Integrin isoform expression in primary human tumors and brain metastases

(2013) Alexander Vogetseder et al.   INTERNATIONAL JOURNAL OF CANCER

Invasion patterns in brain metastases of solid cancers

(2013) Anna S. Berghoff et al.   NEURO-ONCOLOGY

PI3K  activates integrin  4 1 to establish a metastatic niche in lymph nodes

(2013) B. Garmy-Susini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Link between Liver Fibrosis and Hepatocellular Carcinoma

(2013) Toshiharu Sakurai et al.   Liver Cancer

Phase Ib safety and pharmacokinetic study of volociximab, an anti-α5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer

(2012) B. Besse et al.   ANNALS OF ONCOLOGY

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia

(2012) Longxuan Li et al.   EXPERIMENTAL NEUROLOGY

Novel α2β1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation

(2012) Liisa Nissinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

A randomized phase II study of cilengitide (EMD 121974) in patients with metastatic melanoma

(2012) Kevin B. Kim et al.   MELANOMA RESEARCH

EGFR-Mediated Carcinoma Cell Metastasis Mediated by Integrin αvβ5 Depends on Activation of c-Src and Cleavage of MUC1

(2012) Steven K. M. Lau et al.   PLoS One

The Primacy of β1 Integrin Activation in the Metastatic Cascade

(2012) Hisashi Kato et al.   PLoS One

Integrin Targeted Therapeutics

(2012) Melissa Millard et al.   Theranostics

A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma

(2011) S O'Day et al.   BRITISH JOURNAL OF CANCER

Volociximab in cancer

(2011) Salah Almokadem et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

Clinical and pharmacologic evaluation of two dose levels of intetumumab (CNTO 95) in patients with melanoma or angiosarcoma

(2011) Steven J. O’Day et al.   INVESTIGATIONAL NEW DRUGS

Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 Integrin Mediates Interaction of Melanoma Cells with Platelets

(2011) Anke S. Lonsdorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Health-related quality of life among patients with metastatic melanoma

(2011) Donald W. Robinson et al.   MELANOMA RESEARCH

Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: One step forward for overcoming anti-angiogenic drug resistance?

(2011) Iris Helfrich et al.   Molecular Oncology

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation

(2011) M Huang et al.   ONCOGENE

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

(2011) Pipsa Saharinen et al.   TRENDS IN MOLECULAR MEDICINE

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions

(2010) Jochen G. Schneider et al.   BONE

Integrin  4 1 Signaling Is Required for Lymphangiogenesis and Tumor Metastasis

(2010) B. Garmy-Susini et al.   CANCER RESEARCH

Integrin affinity modulation in angiogenesis

(2010) Ganapati H. Mahabeleshwar et al.   CELL CYCLE

Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

(2010) Markus Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis

(2010) A K Mitra et al.   ONCOGENE

Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation

(2010) Perrine Pinon et al.   Pigment Cell & Melanoma Research

Specific Cross-talk between Epidermal Growth Factor Receptor and Integrin αvβ5 Promotes Carcinoma Cell Invasion and Metastasis

(2009) Jill M. Ricono et al.   CANCER RESEARCH

Integrin  2 Mediates Selective Metastasis to the Liver

(2009) K. Yoshimura et al.   CANCER RESEARCH

JWA regulates melanoma metastasis by integrin αVβ3 signaling

(2009) J Bai et al.   ONCOGENE

The Vascular Basement Membrane as “Soil” in Brain Metastasis

(2009) W. Shawn Carbonell et al.   PLoS One

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrins

(2008) Rita Silva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A small molecule inhibitor of α4 integrin-dependent cell migration

(2008) Jongkook Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

 1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

(2008) C. C. Park et al.   CANCER RESEARCH

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH

β1 integrin expression by podocytes is required to maintain glomerular structural integrity

(2008) Ambra Pozzi et al.   DEVELOPMENTAL BIOLOGY

Leukocyte adhesion molecules in animal models of inflammatory bowel disease

(2008) Jesús Rivera-Nieves et al.   INFLAMMATORY BOWEL DISEASES

Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis

(2008) Katie Doeden et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo

(2008) Shoucheng Ning et al.   MOLECULAR CANCER THERAPEUTICS

Melanoma Complicating Treatment with Natalizumab for Multiple Sclerosis

(2008) John T. Mullen et al.   NEW ENGLAND JOURNAL OF MEDICINE