Adenovirus—Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes

Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial

(2020) Suryanarayan Somanathan et al.   MOLECULAR THERAPY

Did Dendritic Cell Activation, Induced by Adenovirus-Antibody Complexes, Play a Role in the Death of Jesse Gelsinger?

(2020) Andrew H. Baker et al.   MOLECULAR THERAPY

Lactoferrin-hexon interactions mediate CAR-independent adenovirus infection of human respiratory cells

(2020) B. David Persson et al.   JOURNAL OF VIROLOGY

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

(2020) Pedro M Folegatti et al.   LANCET

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

(2020) Noe B. Mercado et al.   NATURE

Live Oral Adenovirus Type 4 and Type 7 Vaccine Induces Durable Antibody Response

(2020) Natalie D. Collins et al.   Vaccines

Pros and Cons of Adenovirus-Based SARS-CoV-2 Vaccines

(2020) Eric J. Kremer   MOLECULAR THERAPY

Zika virus infection enhances future risk of severe dengue disease

(2020) Leah C. Katzelnick et al.   SCIENCE

Protective and enhancing interactions among dengue viruses 1-4 and Zika virus

(2020) Leah C Katzelnick et al.   Current Opinion in Virology

Complement C4 Prevents Viral Infection through Capsid Inactivation

(2019) Maria Bottermann et al.   Cell Host & Microbe

Achieving systemic delivery of oncolytic viruses

(2019) Claudia Hill et al.   Expert Opinion on Drug Delivery

Ebola Vaccine Trials: Progress in Vaccine Safety and Immunogenicity

(2019) Keesha M. Matz et al.   Expert Review of Vaccines

Interaction of adenovirus with antibodies, complement, and coagulation factors

(2019) Rondine J. Allen et al.   FEBS LETTERS

Adenoviruses across the animal kingdom: a walk in the zoo

(2019) Balázs Harrach et al.   FEBS LETTERS

Alpha-defensin 5 differentially modulates adenovirus vaccine vectors from different serotypes in vivo

(2019) Lawrence J. Tartaglia et al.   PLoS Pathogens

Intestinal Adenovirus Shedding Before Allogeneic Stem Cell Transplantation Is a Risk Factor for Invasive Infection Post-transplant

(2018) Karin Kosulin et al.   EBioMedicine

Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection

(2018) V. S. Priyadharshini et al.   Canadian Respiratory Journal

Revised Crystal Structure of Human Adenovirus Reveals the Limits on Protein IX Quasi-Equivalence and on Analyzing Large Macromolecular Complexes

(2018) S. Kundhavai Natchiar et al.   JOURNAL OF MOLECULAR BIOLOGY

TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination

(2018) Maria Bottermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells

(2018) Thi Thu Phuong Tran et al.   PLoS Pathogens

Capsid Engineering of Adenovirus Vectors: Overcoming Early Vector–Host Interactions for Therapy

(2017) Claudia Hagedorn et al.   HUMAN GENE THERAPY

Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy

(2017) Charles Vragniau et al.   JOURNAL OF VIROLOGY

The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis

(2016) Xianwei Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy

(2016) A-Rum Yoon et al.   Expert Opinion on Drug Delivery

Old dogs-new tricks: immunoregulatory properties of C3 and C5 cleavage fragments

(2016) Admar Verschoor et al.   IMMUNOLOGICAL REVIEWS

Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation

(2016) Rahul Suresh et al.   JOURNAL OF CELL SCIENCE

Substitution of blood coagulation factor X-binding to Ad5 by position-specific PEGylation: Preventing vector clearance and preserving infectivity

(2016) L. Krutzke et al.   JOURNAL OF CONTROLLED RELEASE

Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01BWith Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP

(2016) Tommy Rampling et al.   JOURNAL OF INFECTIOUS DISEASES

Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21

(2016) Adam J. Fletcher et al.   JOURNAL OF VIROLOGY

Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs

(2016) Julio Alonso-Padilla et al.   MOLECULAR THERAPY

Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells

(2016) Karsten Eichholz et al.   PLoS Pathogens

Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection

(2016) Anshu P. Gounder et al.   PLoS Pathogens

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

(2014) T. Lion   CLINICAL MICROBIOLOGY REVIEWS

The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery

(2014) Estrella Lopez-Gordo et al.   Expert Opinion on Drug Delivery

Lactoferrin Acts as an Alarmin to Promote the Recruitment and Activation of APCs and Antigen-Specific Immune Responses

(2014) G. de la Rosa et al.   JOURNAL OF IMMUNOLOGY

Human Coagulation Factor X-Adenovirus Type 5 Complexes Poorly Stimulate an Innate Immune Response in Human Mononuclear Phagocytes

(2014) Karsten Eichholz et al.   JOURNAL OF VIROLOGY

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

Recombinant human lactoferrin induces human and mouse dendritic cell maturation via Toll-like receptors 2 and 4

(2013) Michela Spadaro et al.   FASEB JOURNAL

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

(2013) Zhili Xu et al.   NATURE MEDICINE

An Intrinsically Disordered Region of the Adenovirus Capsid Is Implicated in Neutralization by Human Alpha Defensin 5

(2013) Justin W. Flatt et al.   PLoS One

Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37

(2012) G. Chamilos et al.   BLOOD

The Human Lactoferrin-Derived Peptide hLF1-11 Exerts Immunomodulatory Effects by Specific Inhibition of Myeloperoxidase Activity

(2012) A. M. van der Does et al.   JOURNAL OF IMMUNOLOGY

Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

(2012) W. A. McEwan et al.   JOURNAL OF VIROLOGY

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

(2012) Christian M Karsten et al.   NATURE MEDICINE

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

(2012) K. Doronin et al.   SCIENCE

Adenovirus receptors: implications for targeting of viral vectors

(2012) Niklas Arnberg   TRENDS IN PHARMACOLOGICAL SCIENCES

Structure of human adenovirus

(2012) Glen R Nemerow et al.   Current Opinion in Virology

Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development

(2011) S Lavilla-Alonso et al.   CANCER GENE THERAPY

Therapeutic plasma proteins - application of proteomics in process optimization, validation, and analysis of the final product

(2011) Dajana Gaso-Sokac et al.   ELECTROPHORESIS

Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus)

(2011) R Alba et al.   GENE THERAPY

The new face of anaphylatoxins in immune regulation

(2011) Wuding Zhou   IMMUNOBIOLOGY

CD209/DC-SIGN mediates efficient infection of monocyte-derived dendritic cells by clinical adenovirus 2C isolates in the presence of bovine lactoferrin

(2011) P. S. Gunther et al.   JOURNAL OF GENERAL VIROLOGY

A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3

(2011) Admar Verschoor et al.   NATURE IMMUNOLOGY

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

(2011) Samuele Calabro et al.   VACCINE

Antimicrobial peptides: General overview and clinical implications in human health and disease

(2010) Eduardo Guaní-Guerra et al.   CLINICAL IMMUNOLOGY

Direct Evidence from Single-Cell Analysis that Human  -Defensins Block Adenovirus Uncoating To Neutralize Infection

(2010) E. K. Nguyen et al.   JOURNAL OF VIROLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of Human Adenovirus at 3.5 A Resolution

(2010) V. S. Reddy et al.   SCIENCE

Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization

(2010) Jason G. Smith et al.   PLoS Pathogens

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

(2009) R. Alba et al.   BLOOD

Proteinases involved in matrix turnover during cartilage and bone breakdown

(2009) Tim E. Cawston et al.   CELL AND TISSUE RESEARCH

Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN

(2009) W. C. Adams et al.   JOURNAL OF GENERAL VIROLOGY

LL-37 Promotes Rapid Sensing of CpG Oligodeoxynucleotides by B Lymphocytes and Plasmacytoid Dendritic Cells

(2009) P. Hurtado et al.   JOURNAL OF IMMUNOLOGY

Antiviral Antibodies Target Adenovirus to Phagolysosomes and Amplify the Innate Immune Response

(2009) A. K. Zaiss et al.   JOURNAL OF IMMUNOLOGY

Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91

(2009) Pietro Presicce et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Coagulation Factors IX and X Enhance Binding and Infection of Adenovirus Types 5 and 31 in Human Epithelial Cells

(2009) M. I. Jonsson et al.   JOURNAL OF VIROLOGY

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

(2009) A. Benlahrech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution

(2009) Elena Seiradake et al.   PLoS Pathogens

Sepsis, apoptosis and complement

(2008) P.A. Ward   BIOCHEMICAL PHARMACOLOGY

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Mechanism of Adenovirus Neutralization by Human α-Defensins

(2008) Jason G. Smith et al.   Cell Host & Microbe

Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells

(2008) Michela Spadaro et al.   FASEB JOURNAL

Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells

(2008) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biodistribution and Toxicological Safety of Adenovirus Type 5 and Type 35 Vectored Vaccines Against Human Immunodeficiency Virus-1 (HIV-1), Ebola, or Marburg Are Similar Despite Differing Adenovirus Serotype Vector, Manufacturer's Construct, or Gene Inserts

(2008) Rebecca L. Sheets et al.   Journal of Immunotoxicology

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

(2008) M Juliana McElrath et al.   LANCET

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

(2008) O. Kalyuzhniy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA