Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

Replication-Defective Adenovirus Vectors with Multiple Deletions Do Not Induce Measurable Vector-Specific T Cells in Human Trials

(2009) R. A. Koup et al.   JOURNAL OF VIROLOGY

Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans

(2009) Kara L O'Brien et al.   NATURE MEDICINE

Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells

(2009) Natalie A Hutnick et al.   NATURE MEDICINE

Human versus HIV: round 2 defeat in AIDS vaccine development

(2008) Shan Lu   Expert Review of Vaccines

Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells

(2008) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?

(2008) Rafick-Pierre Sekaly   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

(2008) M Juliana McElrath et al.   LANCET

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY