Achieving systemic delivery of oncolytic viruses

Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial

(2018) Paul C Lyon et al.   LANCET ONCOLOGY

Oncolytic effect of wild-type Newcastle disease virus isolates in cancer cell lines in vitro and in vivo on xenograft model

(2018) Kseniya S. Yurchenko et al.   PLoS One

Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy

(2018) Marie-Claude Bourgeois-Daigneault et al.   Science Translational Medicine

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

(2018) Adel Samson et al.   Science Translational Medicine

Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy

(2018) Robert A. Berkeley et al.   Cancer Immunology Research

Oncolytic Virotherapy: A Contest between Apples and Oranges

(2017) Stephen J. Russell et al.   MOLECULAR THERAPY

Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins

(2017) Biljana Petrovic et al.   PLoS Pathogens

Oncolytic Viruses in Cancer Treatment

(2017) Sean E. Lawler et al.   JAMA Oncology

Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma

(2016) Praveen K. Bommareddy et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Advances in systemic delivery of anti-cancer agents for the treatment of metastatic cancer

(2016) Megan Grundy et al.   Expert Opinion on Drug Delivery

Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer

(2016) D C Mansfield et al.   GENE THERAPY

Substitution of blood coagulation factor X-binding to Ad5 by position-specific PEGylation: Preventing vector clearance and preserving infectivity

(2016) L. Krutzke et al.   JOURNAL OF CONTROLLED RELEASE

Phase 1 Study of Intravenous Oncolytic Poxvirus (vvDD) in Patients With Advanced Solid Cancers

(2016) Stephanie Downs-Canner et al.   MOLECULAR THERAPY

Under Pressure: Elevated Blood Pressure Enhances Targeting of Tumors by Oncolytic Viruses

(2016) Leonard W Seymour et al.   MOLECULAR THERAPY

Polymeric Cups for Cavitation-mediated Delivery of Oncolytic Vaccinia Virus

(2016) Rachel Myers et al.   MOLECULAR THERAPY

Perfusion Pressure Is a Critical Determinant of the Intratumoral Extravasation of Oncolytic Viruses

(2016) Amber Miller et al.   MOLECULAR THERAPY

Tumour-specific triple-regulated oncolytic herpes virus to target glioma

(2016) Zahid M. Delwar et al.   Oncotarget

Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies

(2016) Juan J. Rojas et al.   Cell Reports

Evaluation of polymer shielding for adenovirus serotype 6 (Ad6) for systemic virotherapy against human prostate cancers

(2016) Tien V Nguyen et al.   Molecular Therapy-Oncolytics

A novel, polymer-coated oncolytic measles virus overcomes immune suppression and induces robust antitumor activity

(2016) Kaname Nosaki et al.   Molecular Therapy-Oncolytics

Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy

(2016) Hasan Rehman et al.   Journal for ImmunoTherapy of Cancer

Tuning Surface Charge and PEGylation of Biocompatible Polymers for Efficient Delivery of Nucleic Acid or Adenoviral Vector

(2015) Joung-Woo Choi et al.   BIOCONJUGATE CHEMISTRY

VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection

(2015) Rozanne Arulanandam et al.   CANCER CELL

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis

(2015) Joung-Woo Choi et al.   JOURNAL OF CONTROLLED RELEASE

Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques

(2015) Laura Evgin et al.   MOLECULAR THERAPY

Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients

(2015) Timothy P Cripe et al.   MOLECULAR THERAPY

First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity

(2015) Herbert J Zeh et al.   MOLECULAR THERAPY

First oncolytic virus edges towards approval in surprise vote

(2015) Cormac Sheridan   NATURE BIOTECHNOLOGY

Halbach arrays consisting of cubic elements optimised for high field gradients in magnetic drug targeting applications

(2015) Lester C Barnsley et al.   PHYSICS IN MEDICINE AND BIOLOGY

Ultrasound-Propelled Nanocups for Drug Delivery

(2015) James J. Kwan et al.   Small

Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy: Translational Opportunity and Open Questions

(2015) Janice Kim et al.   Viruses-Basel

Efficient lung orthotopic tumor-growth suppression of oncolytic adenovirus complexed with RGD-targeted bioreducible polymer

(2014) J Kim et al.   GENE THERAPY

Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma

(2014) Tim D. Pencavel et al.   INTERNATIONAL JOURNAL OF CANCER

Oncolytic vaccinia virus demonstrates antiangiogenic effects mediated by targeting of VEGF

(2014) Weizhou Hou et al.   INTERNATIONAL JOURNAL OF CANCER

Traceless Bioresponsive Shielding of Adenovirus Hexon with HPMA Copolymers Maintains Transduction Capacity In Vitro and In Vivo

(2014) Jan-Michael Prill et al.   PLoS One

Reporter gene imaging identifies intratumoral infection voids as a critical barrier to systemic oncolytic virus efficacy

(2014) Amber Miller et al.   Molecular Therapy-Oncolytics

Therapeutic efficacy of a systemically delivered oncolytic adenovirus – Biodegradable polymer complex

(2013) Jaesung Kim et al.   BIOMATERIALS

Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients

(2013) Michael A. Morse et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans

(2013) C. J. Breitbach et al.   CANCER RESEARCH

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Therapeutic targeting of chitosan–PEG–folate-complexed oncolytic adenovirus for active and systemic cancer gene therapy

(2013) Oh-Joon Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced Tumor Uptake and Penetration of Virotherapy Using Polymer Stealthing and Focused Ultrasound

(2013) Robert Carlisle et al.   JNCI-Journal of the National Cancer Institute

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

(2013) Ilkka Liikanen et al.   MOLECULAR THERAPY

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

Multifunctional particles for melanoma-targeted drug delivery

(2012) Aniket S. Wadajkar et al.   Acta Biomaterialia

Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses

(2012) Ziyue Karen Jiang et al.   JOURNAL OF CONTROLLED RELEASE

Attenuation of Semliki Forest Virus Neurovirulence by MicroRNA-Mediated Detargeting

(2012) E. Ylosmaki et al.   JOURNAL OF VIROLOGY

Odyssey of a cancer nanoparticle: From injection site to site of action

(2012) Joseph W. Nichols et al.   Nano Today

Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer

(2012) Nicola K Green et al.   Nanomedicine

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients

(2012) R. A. Adair et al.   Science Translational Medicine

Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway

(2011) Takahiro Seki et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA-sensitive Oncolytic Measles Viruses for Cancer-specific Vector Tropism

(2011) Mathias F Leber et al.   MOLECULAR THERAPY

MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus Reduces Viral Pathogenicity Without Impairing Its Antitumor Efficacy

(2011) Mina Hikichi et al.   MOLECULAR THERAPY

A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

(2011) Tae-Ho Hwang et al.   MOLECULAR THERAPY

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

(2011) Caroline J. Breitbach et al.   NATURE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Cavitation-Enhanced Extravasation for Drug Delivery

(2011) Costas D. Arvanitis et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

A phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: Armed oncolytic adenovirus for the treatment of head and neck cancers

(2010) Jianhua Chang et al.   CANCER BIOLOGY & THERAPY

Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair

(2010) Yufang Shi et al.   CELL RESEARCH

Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck

(2010) K. J. Harrington et al.   CLINICAL CANCER RESEARCH

Head and neck cancer: Response to p53-based therapeutics

(2010) Jackie Nemunaitis et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Enhanced oncolysis mediated by Coxsackievirus A21 in combination with doxorubicin hydrochloride

(2010) Kathryn A. Skelding et al.   INVESTIGATIONAL NEW DRUGS

Magnetically guided lentiviral-mediated transduction of airway epithelial cells

(2010) Clara Orlando et al.   JOURNAL OF GENE MEDICINE

Cavitation-enhanced delivery of macromolecules into an obstructed vessel

(2010) Bassel Rifai et al.   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Effect of Pazopanib on Tumor Microenvironment and Liposome Delivery

(2010) T. D. Tailor et al.   MOLECULAR CANCER THERAPEUTICS

Boosting Oncolytic Adenovirus Potency with Magnetic Nanoparticles and Magnetic Force

(2010) Nittaya Tresilwised et al.   MOLECULAR PHARMACEUTICS

Epigenetic Mechanisms Regulate MHC and Antigen Processing Molecules in Human Embryonic and Induced Pluripotent Stem Cells

(2010) Beatriz Suárez-Álvarez et al.   PLoS One

PEGylated Adenoviruses: From Mice to Monkeys

(2010) Piyanuch Wonganan et al.   Viruses-Basel

Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV Melanoma

(2009) Howard L. Kaufman et al.   ANNALS OF SURGICAL ONCOLOGY

MicroRNA Regulation of Oncolytic Herpes Simplex Virus-1 for Selective Killing of Prostate Cancer Cells

(2009) C. Y. F. Lee et al.   CLINICAL CANCER RESEARCH

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

(2009) Neil N. Senzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Polymer-Enhanced Adenoviral Transduction of CAR-Negative Bladder Cancer Cells

(2009) Laura M. Kasman et al.   MOLECULAR PHARMACEUTICS

Cell Carriers for Oncolytic Viruses: Fed Ex for Cancer Therapy

(2009) Candice Willmon et al.   MOLECULAR THERAPY

Eradication of Therapy-resistant Human Prostate Tumors Using an Ultrasound-guided Site-specific Cancer Terminator Virus Delivery Approach

(2009) Adelaide Greco et al.   MOLECULAR THERAPY

Cavitation and contrast: The use of bubbles in ultrasound imaging and therapy

(2009) E P Stride et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Taming Vessels to Treat Cancer

(2009) Rakesh K. Jain   SCIENTIFIC AMERICAN

Designer adenoviruses for nanomedicine and nanodiagnostics

(2009) Ravi Singh et al.   TRENDS IN BIOTECHNOLOGY

Enhancing Poxvirus Oncolytic Effects through Increased Spread and Immune Evasion

(2008) D. H. Kirn et al.   CANCER RESEARCH

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

(2008) J. H.E. Baker et al.   CLINICAL CANCER RESEARCH

A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients

(2008) J-L Li et al.   GENE THERAPY

Targeting and Purification of Metabolically Biotinylated Baculovirus

(2008) Minna U. Kaikkonen et al.   HUMAN GENE THERAPY

Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer

(2008) Nicola K. Green et al.   JOURNAL OF GENE MEDICINE

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

(2008) Byeong-Ho Park et al.   LANCET ONCOLOGY

A let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication

(2008) Robert E Edge et al.   MOLECULAR THERAPY

Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM

(2008) James M Markert et al.   MOLECULAR THERAPY

Engineering microRNA responsiveness to decrease virus pathogenicity

(2008) Elizabeth J Kelly et al.   NATURE MEDICINE

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

(2008) Roberto Cattaneo et al.   NATURE REVIEWS MICROBIOLOGY

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

(2008) Irene Kuhn et al.   PLoS One

Biocompatible polymer materials: Role of protein–surface interactions

(2008) Hong Chen et al.   PROGRESS IN POLYMER SCIENCE

Virotherapy of Ovarian Cancer With Polymer-cloaked Adenovirus Retargeted to the Epidermal Growth Factor Receptor

(2007) Joanne Morrison et al.   MOLECULAR THERAPY