Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells

The Persistent Mystery of Adenovirus Persistence

(2016) Cason R. King et al.   TRENDS IN MICROBIOLOGY

Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses

(2015) Alvaro Ortega-Esteban et al.   ACS Nano

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

(2015) Rajendra Karki et al.   Cell Host & Microbe

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Ebola virus vaccine: benefit and risks of adenovirus-based vectors

(2015) Franck JD Mennechet et al.   Expert Review of Vaccines

Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4

(2015) Inhwa Hwang et al.   IMMUNOLOGY AND CELL BIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Adenovirus membrane penetration: Tickling the tail of a sleeping dragon

(2015) Christopher M. Wiethoff et al.   VIROLOGY

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

(2015) Seamus R. Morrone et al.   Nature Communications

Ebola vaccines based on adenovirus vectors and risk of HIV

(2015) E. J. Kremer et al.   BMJ-British Medical Journal

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

Adenovirus Tales: From the Cell Surface to the Nuclear Pore Complex

(2015) Eric J. Kremer et al.   PLoS Pathogens

Ebola vaccines based on adenovirus vectors and risk of HIV

(2015) E. J. Kremer et al.   BMJ-British Medical Journal

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

(2014) T. Lion   CLINICAL MICROBIOLOGY REVIEWS

Autophagy Induced by Calcium Phosphate Precipitates Targets Damaged Endosomes

(2014) Xi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Immune Complexes Inhibit IL-1 Secretion and Inflammasome Activation

(2014) John R. Janczy et al.   JOURNAL OF IMMUNOLOGY

Identification of Aim2 as a Sensor for DNA Vaccines

(2014) John J. Suschak et al.   JOURNAL OF IMMUNOLOGY

Human Coagulation Factor X-Adenovirus Type 5 Complexes Poorly Stimulate an Innate Immune Response in Human Mononuclear Phagocytes

(2014) Karsten Eichholz et al.   JOURNAL OF VIROLOGY

The Amphipathic Helix of Adenovirus Capsid Protein VI Contributes to Penton Release and Postentry Sorting

(2014) Ruben Martinez et al.   JOURNAL OF VIROLOGY

Increased Mucosal CD4+ T Cell Activation in Rhesus Macaques following Vaccination with an Adenoviral Vector

(2014) I. Bukh et al.   JOURNAL OF VIROLOGY

Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study

(2014) Glenda E Gray et al.   LANCET INFECTIOUS DISEASES

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals

(2014) Haitao Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, Function and Dynamics in Adenovirus Maturation

(2014) Walter Mangel et al.   Viruses-Basel

Cutting-Edge Analysis of Extracellular Microparticles using ImageStreamX Imaging Flow Cytometry

(2014) Sarah E. Headland et al.   Scientific Reports

Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

(2014) Parisa Kalantari et al.   Cell Reports

Of inflammasomes and pathogens - sensing of microbes by the inflammasome

(2013) Franz Bauernfeind et al.   EMBO Molecular Medicine

The interferon response to intracellular DNA: Why so many receptors?

(2013) Leonie Unterholzner   IMMUNOBIOLOGY

HIV-1 Induces the First Signal to Activate the NLRP3 Inflammasome in Monocyte-Derived Macrophages

(2013) Juan C. Hernandez et al.   INTERVIROLOGY

Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

(2013) J. J. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5

(2013) Matthias Schulte et al.   SpringerPlus

Risk Factors for Molecular Detection of Adenovirus in Pediatric Hematopoietic Stem Cell Transplantation Recipients

(2012) Theresa Watson et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc RIIa in human dendritic cells

(2012) J. den Dunnen et al.   BLOOD

Gene Immunotherapy of Chronic Lymphocytic Leukemia: A Phase I Study of Intranodally Injected Adenovirus Expressing a Chimeric CD154 Molecule

(2012) J. E. Castro et al.   CANCER RESEARCH

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

(2012) Jill Henault et al.   IMMUNITY

Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)

(2012) A. Duerr et al.   JOURNAL OF INFECTIOUS DISEASES

The Number of Toll-Like Receptor 9-Agonist Motifs in the Adenovirus Genome Correlates with Induction of Dendritic Cell Maturation by Adenovirus Immune Complexes

(2012) M. Perreau et al.   JOURNAL OF VIROLOGY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Infectious Etiologies of Transient Neutropenia in Previously Healthy Children

(2012) Entesar H. Husain et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

(2012) Benjamin H. Lee et al.   PLoS One

Autonomous phagosomal degradation and antigen presentation in dendritic cells

(2012) E. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disulfide-bond formation by a single cysteine mutation in adenovirus protein VI impairs capsid release and membrane lysis

(2012) Crystal L. Moyer et al.   VIROLOGY

Evaluation of nanoparticle tracking analysis for total virus particle determination

(2012) Petra Kramberger et al.   Virology Journal

IFN-  enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing

(2011) F. Spadaro et al.   BLOOD

High Titers of Pre-existing Adenovirus Serotype-Specific Neutralizing Antibodies in the Host Predict Viral Reactivation After Allogeneic Stem Cell Transplantation in Children

(2011) Louise A. Veltrop-Duits et al.   CLINICAL INFECTIOUS DISEASES

Cytosolic DNA-Activated Human Dendritic Cells Are Potent Activators of the Adaptive Immune Response

(2011) K. Kis-Toth et al.   JOURNAL OF IMMUNOLOGY

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

Functional Genetic and Biophysical Analyses of Membrane Disruption by Human Adenovirus

(2011) C. L. Moyer et al.   JOURNAL OF VIROLOGY

Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species

(2011) K. A. McGuire et al.   JOURNAL OF VIROLOGY

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Pre-Existing Adenovirus Immunity Modifies a Complex Mixed Th1 and Th2 Cytokine Response to an Ad5/HIV-1 Vaccine Candidate in Humans

(2011) Samuel O. Pine et al.   PLoS One

Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome

(2011) A.U. Barlan et al.   VIROLOGY

Strong Association between Respiratory Viral Infection Early after Hematopoietic Stem Cell Transplantation and the Development of Life-Threatening Acute and Chronic Alloimmune Lung Syndromes

(2010) A.Birgitta Versluys et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Respiratory viruses, a common microbiological finding in neutropenic children with fever

(2010) Anna Lindblom et al.   JOURNAL OF CLINICAL VIROLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

Different cytokine signatures in children with localized and invasive adenovirus infection after stem cell transplantation

(2010) Lianne M. Haveman et al.   PEDIATRIC TRANSPLANTATION

Monocyte-Derived Dendritic Cells Exhibit Increased Levels of Lysosomal Proteolysis as Compared to Other Human Dendritic Cell Populations

(2010) Nathanael McCurley et al.   PLoS One

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin α4β7

(2009) Geothy Chakupurakal et al.   AIDS

Long-lasting cross-presentation of tumor antigen in human DC

(2009) Florence Faure et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antiviral Antibodies Target Adenovirus to Phagolysosomes and Amplify the Innate Immune Response

(2009) A. K. Zaiss et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

CAR-Associated Vesicular Transport of an Adenovirus in Motor Neuron Axons

(2009) Sara Salinas et al.   PLoS Pathogens

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells

(2008) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutralizing Antibody Blocks Adenovirus Infection by Arresting Microtubule-Dependent Cytoplasmic Transport

(2008) J. G. Smith et al.   JOURNAL OF VIROLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY