In vitroandin vivosmall intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences

Predicting Drug – Drug Interactions Involving the Inhibition of Intestinal CYP3A4 and P-Glycoprotein

(2011) Tatsuhiko Tachibana et al.   CURRENT DRUG METABOLISM

Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse

(2011) Y. Zhu et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Intestinal First-Pass Metabolism of CYP3A Substrates in Humans Using Cynomolgus Monkeys

(2010) H. Nishimuta et al.   DRUG METABOLISM AND DISPOSITION

Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples

(2010) W. Brand et al.   DRUG METABOLISM AND DISPOSITION

Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys

(2010) T. Ohtsuka et al.   DRUG METABOLISM AND DISPOSITION

Comparison of Cytochrome P450 3A Enzymes in Cynomolgus Monkeys and Humans

(2010) Kazuhide Iwasaki et al.   Drug Metabolism and Pharmacokinetics

Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus Monkeys

(2010) Yasuharu Nakanishi et al.   Drug Metabolism and Pharmacokinetics

Transfer of human artificial chromosome vectors into stem cells

(2010) Mitsuo Oshimura et al.   REPRODUCTIVE BIOMEDICINE ONLINE

A Comparison of Pharmacokinetics between Humans and Monkeys

(2009) T. Akabane et al.   DRUG METABOLISM AND DISPOSITION

Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam

(2009) R. A. B. van Waterschoot et al.   DRUG METABOLISM AND DISPOSITION

Genetic Variants of CYP3A4 and CYP3A5 in Cynomolgus and Rhesus Macaques

(2009) Y. Uno et al.   DRUG METABOLISM AND DISPOSITION

Effect of Intestinal and Hepatic First-pass Extraction on the Pharmacokinetics of Everolimus in Rats

(2009) Akira Yokomasu et al.   Drug Metabolism and Pharmacokinetics

Tissue-Specific mRNA Expression Profiles of Drug-Metabolizing Enzymes and Transporters in the Cynomolgus Monkey

(2009) Masuhiro Nishimura et al.   Drug Metabolism and Pharmacokinetics

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping andin vitro–in vivoextrapolation of drug clearance and drug-drug interaction potential

(2009) John O. Miners et al.   DRUG METABOLISM REVIEWS

Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: A study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10

(2009) Takashi Mizuma   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans

(2009) Masayuki Takahashi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes

(2009) Ryoichi Fujiwara et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pregnancy Does Not Increase CYP3A or P-Glycoprotein Activity in the Non-Human Primate, Macaca nemestrina

(2009) H. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of St. John's wort extract on indinavir pharmacokinetics in rats: Differentiation of intestinal and hepatic impacts

(2009) Yunn-Fang Ho et al.   LIFE SCIENCES

Structure and Concentration Changes Affect Characterization of UGT Isoform-Specific Metabolism of Isoflavones

(2009) Lan Tang et al.   MOLECULAR PHARMACEUTICS

Relative Importance of Intestinal and Hepatic Glucuronidation—Impact on the Prediction of Drug Clearance

(2009) Helen E. Cubitt et al.   PHARMACEUTICAL RESEARCH

How important is intestinal cytochrome P450 3A metabolism?

(2009) Antonius E. van Herwaarden et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of ursodeoxycholic acid on the pharmacokinetics of midazolam and CYP3A in the liver and intestine of rats

(2009) S. Kurosawa et al.   XENOBIOTICA

Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice

(2009) J. Kuze et al.   XENOBIOTICA

Cynomolgus monkey CYPs: a comparison with human CYPs

(2009) K. Iwasaki et al.   XENOBIOTICA

Grapefruit Juice-Drug Interaction Studies as a Method to Assess the Extent of Intestinal Availability: Utility and Limitations

(2008) Michael Gertz et al.   CURRENT DRUG METABOLISM

An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

(2008) Q.-Y. Zhang et al.   DRUG METABOLISM AND DISPOSITION

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

(2008) S. Ohno et al.   DRUG METABOLISM AND DISPOSITION

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines

(2008) A. Nakamura et al.   DRUG METABOLISM AND DISPOSITION

Stereoselective First-Pass Metabolism of Verapamil in the Small Intestine and Liver in Rats

(2008) K. Hanada et al.   DRUG METABOLISM AND DISPOSITION

Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyltransferase 1A10

(2008) K. Itaaho et al.   DRUG METABOLISM AND DISPOSITION

Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers

(2008) W. Brand et al.   DRUG METABOLISM AND DISPOSITION

Species Differences in UDP-Glucuronosyltransferase Activities in Mice and Rats

(2008) H. Shiratani et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetics of Amitriptyline and One of Its Metabolites, Nortriptyline, in Rats: Little Contribution of Considerable Hepatic First-Pass Effect to Low Bioavailability of Amitriptyline Due to Great Intestinal First-Pass Effect

(2008) Soo K. Bae et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Decreased Oral Absorption of Cyclosporine A after Liver Ischemia-Reperfusion Injury in Rats: The Contribution of CYP3A and P-Glycoprotein to the First-Pass Metabolism in Intestinal Epithelial Cells

(2008) K. Ikemura et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Differential expression ofCYP3A12andCYP3A26mRNAs in canine liver and intestine

(2008) K. L. Mealey et al.   XENOBIOTICA

Species Differences in In Vitro and In Vivo Small Intestinal Metabolism of CYP3A Substrates

(2007) Hiroshi Komura et al.   JOURNAL OF PHARMACEUTICAL SCIENCES