Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study

Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: Current and future challenges

(2020) Ming Li et al.   PHARMACOLOGY & THERAPEUTICS

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

(2020) Irina V. Il’ina et al.   MOLECULES

Updates in bile acid-bioactive molecule conjugates and their applications

(2020) Roli Mishra et al.   STEROIDS

Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer

(2019) Huawei Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening

(2019) George T Lountos et al.   NUCLEIC ACIDS RESEARCH

Semisynthetic bile acids: a new therapeutic option for metabolic syndrome

(2019) Slavica Lazarević et al.   PHARMACOLOGICAL RESEARCH

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

(2019) Filimonov et al.   MOLECULES

Irinotecan: 25 years of cancer treatment

(2019) Christian Bailly   PHARMACOLOGICAL RESEARCH

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

(2019) Tatyana M. Khomenko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bile acid receptors in the biliary tree: TGR5 in physiology and disease

(2018) Kathleen Deutschmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

(2018) Oksana Salomatina et al.   MOLECULES

Synthesis and antimalarial activity of 3′-trifluoromethylated 1,2,4-trioxolanes and 1,2,4,5-tetraoxane based on deoxycholic acid

(2018) Emil Yu. Yamansarov et al.   STEROIDS

Bile Acids Activated Receptors Regulate Innate Immunity

(2018) Stefano Fiorucci et al.   Frontiers in Immunology

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models

(2018) A.L. Zakharenko et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening

(2018) Chatchakorn Eurtivong et al.   Molecular Informatics

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl–DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl–DNA Phosphodiesterase 2 (Tdp2)

(2017) Ping Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Nucleoside–Bile Acid Conjugates Incorporating a Triazole Moiety for Anticancer Evaluation and SAR Exploration

(2017) Maria Navacchia et al.   MOLECULES

Modern approaches to modification of bile acids for the synthesis of compounds possessing valuable physicochemical and biological properties

(2017) I I Popadyuk et al.   RUSSIAN CHEMICAL REVIEWS

Current status of poly(ADP-ribose) polymerase inhibitors and future directions

(2017) Akihiro Ohmoto et al.   OncoTargets and Therapy

Bilosomes in the context of oral immunization: development, challenges and opportunities

(2016) Anshuman Shukla et al.   DRUG DISCOVERY TODAY

Bile acids and bile acid derivatives: use in drug delivery systems and as therapeutic agents

(2016) Célia Faustino et al.   Expert Opinion on Drug Delivery

Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules

(2016) Bryan L. Copple et al.   PHARMACOLOGICAL RESEARCH

Deoxycholic acid derivatives as inhibitors of P-glycoprotein-mediated multidrug efflux

(2016) Luc Rocheblave et al.   STEROIDS

Design and strategies for bile acid mediated therapy and imaging

(2016) Md Nurunnabi et al.   RSC Advances

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

(2015) Alexandra Zakharenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Defining Known Drug Space Using DFT

(2015) Anna M. Matuszek et al.   Molecular Informatics

Bile acid nuclear receptor FXR and digestive system diseases

(2015) Lili Ding et al.   Acta Pharmaceutica Sinica B

Application of bile acids in drug formulation and delivery

(2014) Maja Stojančević et al.   Frontiers in Life Science

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy

(2012) Thomas Dexheimer et al.   Anti-Cancer Agents in Medicinal Chemistry

Glycochenodeoxycholate induces rat alveolar epithelial type II cell death and inhibits surfactant secretion in vitro

(2012) Hu Zhangxue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study

(2012) Feng Zhu et al.   Molecular Informatics

Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery

(2011) Werner Kramer   BIOLOGICAL CHEMISTRY

AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1

(2011) Natalia A. Lebedeva et al.   FEBS LETTERS

Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily

(2011) Stefan Gajewski et al.   JOURNAL OF MOLECULAR BIOLOGY

Tyrosyl-DNA Phosphodiesterase 1 Targeting for Modulation of Camptothecin-Based Treatment

(2010) G. Beretta et al.   CURRENT MEDICINAL CHEMISTRY

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

(2009) Sherif F. El-Khamisy et al.   DNA REPAIR

Empirical Scoring Functions for Advanced Protein−Ligand Docking with PLANTS

(2009) Oliver Korb et al.   Journal of Chemical Information and Modeling

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors

(2009) Thomas S. Dexheimer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Benchmarking the Reliability of QikProp. Correlation between Experimental and Predicted Values

(2007) Leukothea Ioakimidis et al.   Quantitative structure-activity relationships & combinatorial science