New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

Antimetastatic Activity of Combined Topotecan and Tyrosyl-DNA Phosphodiesterase-1 Inhibitor on Modeled Lewis Lung Carcinoma

(2019) E. V. Koldysheva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Enantioselective activity of usnic acid: a comprehensive review and future perspectives

(2019) Agnieszka Galanty et al.   PHYTOCHEMISTRY REVIEWS

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

(2019) Arduino A. Mangoni et al.   MOLECULES

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening

(2019) George T Lountos et al.   NUCLEIC ACIDS RESEARCH

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

(2019) Arina A. Chepanova et al.   Applied Sciences-Basel

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors

(2018) Konstantin Yu. Ponomarev et al.   BIOORGANIC CHEMISTRY

Usnic acid and its derivatives for pharmaceutical use: a patent review (2000–2017)

(2018) Olga A. Luzina et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

(2018) Oksana Salomatina et al.   MOLECULES

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold

(2018) Nikolai Li-Zhulanov et al.   MOLECULES

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

(2018) Evgenii S. Mozhaitsev et al.   Anti-Cancer Agents in Medicinal Chemistry

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models

(2018) A.L. Zakharenko et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening

(2018) Chatchakorn Eurtivong et al.   Molecular Informatics

Novel inhibitors of tyrosinase produced by the 4-substitution of TCT

(2017) Jian Xu et al.   FOOD CHEMISTRY

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl–DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl–DNA Phosphodiesterase 2 (Tdp2)

(2017) Ping Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation

(2017) Ajinkya S Kawale et al.   NUCLEIC ACIDS RESEARCH

Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1

(2017) A. L. Zakharenko et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

(2016) Tatyana Khomenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential

(2016) Sergey S. Laev et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitory effect of synthetic aromatic heterocycle thiosemicarbazone derivatives on mushroom tyrosinase: Insights from fluorescence, 1 H NMR titration and molecular docking studies

(2016) Juan Xie et al.   FOOD CHEMISTRY

Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin

(2016) Alexandra Zakharenko et al.   JOURNAL OF NATURAL PRODUCTS

Biological activity of usnic acid and its derivatives: Part 2. effects on higher organisms. Molecular and physicochemical aspects

(2016) O. A. Luzina et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Biological activity of usnic acid and its derivatives: Part 1. Activity against unicellular organisms

(2016) O. A. Luzina et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Synthesis of a Sugar-Based Thiosemicarbazone Series and Structure-Activity Relationship versus the Parasite Cysteine Proteases Rhodesain, Cruzain, and Schistosoma mansoni Cathepsin B1

(2015) Nayara Cristina Fonseca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

(2015) Alexandra Zakharenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alkylation of NH-, OH-, and SH-acids in the presence of potassium carbonate

(2015) D. S. Khachatryan et al.   RUSSIAN CHEMICAL BULLETIN

A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues

(2015) Homayon J. Arabshahi et al.   MedChemComm

Targeting DNA damage response in cancer therapy

(2014) Noriko Hosoya et al.   CANCER SCIENCE

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: Structural design, synthesis and pharmacological evaluation

(2014) Marcos Veríssimo de Oliveira Cardoso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural Studies and Investigation on the Activity of Imidazole-Derived Thiosemicarbazones and Hydrazones against Crop-Related Fungi

(2013) Débora Reis et al.   MOLECULES

Synthesis of aurones based on usninic acid

(2012) O. A. Luzina et al.   CHEMISTRY OF NATURAL COMPOUNDS

Tyrosyl-DNA Phosphodiesterase 1 Inhibitor from an Anamorphic Fungus

(2012) Motoki Takagi et al.   JOURNAL OF NATURAL PRODUCTS

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study

(2012) Feng Zhu et al.   Molecular Informatics

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition

(2011) Paola Perego et al.   BIOCHEMICAL PHARMACOLOGY

Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase

(2011) Wei Yi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1

(2011) Natalia A. Lebedeva et al.   FEBS LETTERS

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Empirical Scoring Functions for Advanced Protein−Ligand Docking with PLANTS

(2009) Oliver Korb et al.   Journal of Chemical Information and Modeling

Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes

(2009) Kusaï Alomar et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

(2009) C. Marchand et al.   MOLECULAR CANCER THERAPEUTICS

Mechanism of Meerwein arylation of furan derivatives

(2009) N. D. Obushak et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Benchmarking the Reliability of QikProp. Correlation between Experimental and Predicted Values

(2007) Leukothea Ioakimidis et al.   Quantitative structure-activity relationships & combinatorial science