Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors

(2018) Konstantin Yu. Ponomarev et al.   BIOORGANIC CHEMISTRY

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl–DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl–DNA Phosphodiesterase 2 (Tdp2)

(2017) Ping Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Nucleoside–Bile Acid Conjugates Incorporating a Triazole Moiety for Anticancer Evaluation and SAR Exploration

(2017) Maria Navacchia et al.   MOLECULES

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation

(2017) Ajinkya S Kawale et al.   NUCLEIC ACIDS RESEARCH

Modern approaches to modification of bile acids for the synthesis of compounds possessing valuable physicochemical and biological properties

(2017) I I Popadyuk et al.   RUSSIAN CHEMICAL REVIEWS

The neuroprotective effect of nicotine in Parkinson’s disease models is associated with inhibiting PARP-1 and caspase-3 cleavage

(2017) Justin Y.D. Lu et al.   PeerJ

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

(2016) Tatyana Khomenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential

(2016) Sergey S. Laev et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics with a Combination of AsiDNA and PARP Inhibitors

(2016) Wael Jdey et al.   CLINICAL CANCER RESEARCH

Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin

(2016) Alexandra Zakharenko et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

(2015) Alexandra Zakharenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Nitrated 7-, 8-, 9-, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase I (Top1)–Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors

(2015) Trung Xuan Nguyen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells

(2015) Miguel Angel Borda et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target

(2014) Evan Q. Comeaux et al.   DRUG METABOLISM REVIEWS

Synthesis and biological evaluation of bile carboxamide derivatives with pro-apoptotic effect on human colon adenocarcinoma cell lines

(2014) Dominique Brossard et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

(2014) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Synthesis and Biological Activity of Some Bile Acid-Based Camptothecin Analogues

(2014) Xingnuo Li et al.   MOLECULES

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

(2013) M. Alagoz et al.   NUCLEIC ACIDS RESEARCH

Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy

(2012) Thomas Dexheimer et al.   Anti-Cancer Agents in Medicinal Chemistry

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

(2012) Junko Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors

(2012) Trung Xuan Nguyen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study

(2012) Feng Zhu et al.   Molecular Informatics

Advances in Bile Acid Medicinal Chemistry

(2011) R. Sharma et al.   CURRENT MEDICINAL CHEMISTRY

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

(2011) Shar-yin N Huang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1

(2011) Natalia A. Lebedeva et al.   FEBS LETTERS

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Tyrosyl-DNA Phosphodiesterase 1 Targeting for Modulation of Camptothecin-Based Treatment

(2010) G. Beretta et al.   CURRENT MEDICINAL CHEMISTRY

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

(2009) Sherif F. El-Khamisy et al.   DNA REPAIR

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

(2009) Benu Brata Das et al.   EMBO JOURNAL

Empirical Scoring Functions for Advanced Protein−Ligand Docking with PLANTS

(2009) Oliver Korb et al.   Journal of Chemical Information and Modeling

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors

(2009) Thomas S. Dexheimer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE