Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery

A Quantitative Structure–Activity Relationship for Translocation of Tripeptides via the Human Proton-Coupled Peptide Transporter, hPEPT1 (SLC15A1)

(2010) Diana Højmark Omkvist et al.   AAPS Journal

Mechanism and regulation of folate uptake by pancreatic acinar cells: effect of chronic alcohol consumption

(2010) Hamid M. Said et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bioavailability Through PepT1: The Role of Computer Modelling in Intelligent Drug Design

(2010) David Foley et al.   Current Computer-Aided Drug Design

Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4

(2010) M. Rius et al.   DRUG METABOLISM AND DISPOSITION

Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBT

(2010) Xiaowan Zheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry

(2010) Lei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transporters in drug development: advancing on the Critical Path

(2010) Shiew-Mei Huang et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin

(2010) Ligong Chen et al.   Pharmacogenetics and Genomics

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugs

(2009) Bradley L. Urquhart et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Synthesis and Characterization of New Liver Targeting 5-Fluorouracil-Cholic Acid Conjugates

(2009) Shan Qian et al.   ARCHIV DER PHARMAZIE

Drug Transporters: Recent Advances and Therapeutic Applications

(2009) R M Franke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Liver Transporters in Hepatic Drug Disposition: An Update

(2009) Peng Li et al.   CURRENT DRUG METABOLISM

Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls

(2009) Matthias Brandsch   Expert Opinion on Drug Metabolism & Toxicology

Dapagliflozin: where does it fit in the treatment of type 2 diabetes?

(2009) Vincent C Woo   EXPERT OPINION ON PHARMACOTHERAPY

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

(2009) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arbaclofen Placarbil, a Novel R-Baclofen Prodrug: Improved Absorption, Distribution, Metabolism, and Elimination Properties Compared with R-Baclofen

(2009) R. Lal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1

(2009) David Foley et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

(2009) David Foley et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bile acids: Chemistry, physiology, and pathophysiology

(2009) Maria J Monte et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dipeptide Derivatives of AZT: Synthesis, Chemical Stability, Activation in Human Plasma, hPEPT1 Affinity, and Antiviral Activity

(2008) Cledir Santos et al.   ChemMedChem

Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

(2008) IS Song et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Peptide prodrugs: Improved oral absorption of lopinavir, a HIV protease inhibitor

(2008) Sheetal Agarwal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Clinical Pharmacokinetics of XP13512, a Novel Transported Prodrug of Gabapentin

(2008) Kenneth C. Cundy et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Targeting the Delivery of Glycan-Based Paclitaxel Prodrugs to Cancer Cells via Glucose Transporters

(2008) Yih-Shyan Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmaceutical and pharmacological importance of peptide transporters

(2008) Matthias Brandsch et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters

(2008) Yasuhiro Tsume et al.   MOLECULES

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney

(2008) Zoulikha M Zaïr et al.   PHARMACOGENOMICS

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

(2008) B. Hagenbuch et al.   XENOBIOTICA

A regulatory viewpoint on transporter-based drug interactions

(2008) L. Zhang et al.   XENOBIOTICA

Peptide transporters and their roles in physiological processes and drug disposition

(2008) I. Rubio-Aliaga et al.   XENOBIOTICA