Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

Synthesis of isobenzofuran derivatives from renewable 2-carene over halloysite nanotubes

(2020) A.Yu. Sidorenko et al.   Molecular Catalysis

Dual DNA topoisomerase 1 and tyrosyl‐DNA phosphodiesterase 1 inhibition for improved anticancer activity

(2019) Alexandra Zakharenko et al.   MEDICINAL RESEARCH REVIEWS

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

(2019) Arina A. Chepanova et al.   Applied Sciences-Basel

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

(2019) Filimonov et al.   MOLECULES

Tyrosyl-DNA Phosphodiesterase I N-Terminal Domain Modifications and Interactions Regulate Cellular Function

(2019) Brettrager et al.   Genes

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

(2019) Tatyana M. Khomenko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors

(2018) Konstantin Yu. Ponomarev et al.   BIOORGANIC CHEMISTRY

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

(2018) Oksana Salomatina et al.   MOLECULES

Synthesis of oxygen-containing heterocyclic compounds based on monoterpenoids

(2018) O S Patrusheva et al.   RUSSIAN CHEMICAL REVIEWS

Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors

(2018) Olga Zakharova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold

(2018) Nikolai Li-Zhulanov et al.   MOLECULES

Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1

(2018) Nadezhda Dyrkheeva et al.   PLANTA MEDICA

Preparation of chiral isobenzofurans from 3-carene in the presence of modified clays

(2018) A.Yu. Sidorenko et al.   Molecular Catalysis

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

(2018) Evgenii S. Mozhaitsev et al.   Anti-Cancer Agents in Medicinal Chemistry

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models

(2018) A.L. Zakharenko et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The development of Tyrosyl-DNA Phosphodyesterase 1 (TDP1) inhibitors based on the amines combining Aromatic/Heteroaromatic and Monoterpenoid Moieties

(2018) Evgenii Mozhaitsev et al.   Letters in Drug Design & Discovery

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening

(2018) Chatchakorn Eurtivong et al.   Molecular Informatics

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation

(2017) Ajinkya S Kawale et al.   NUCLEIC ACIDS RESEARCH

Monoterpenes as a renewable source of biologically active compounds

(2017) Nariman F. Salakhutdinov et al.   PURE AND APPLIED CHEMISTRY

Catalytic isomerization of α-pinene and 3-carene in the presence of modified layered aluminosilicates

(2017) A.Yu. Sidorenko et al.   Molecular Catalysis

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

(2016) Tatyana Khomenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential

(2016) Sergey S. Laev et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

(2015) Alexandra Zakharenko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity

(2015) Papiya Majumdar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms

(2014) Sariah Liu et al.   CANCER TREATMENT REVIEWS

Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

(2014) Alla Pavlova et al.   Letters in Drug Design & Discovery

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy

(2012) Thomas Dexheimer et al.   Anti-Cancer Agents in Medicinal Chemistry

Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study

(2012) Feng Zhu et al.   Molecular Informatics

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

(2011) Shar-yin N Huang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1

(2011) Natalia A. Lebedeva et al.   FEBS LETTERS

Tyrosyl-DNA Phosphodiesterase 1 Targeting for Modulation of Camptothecin-Based Treatment

(2010) G. Beretta et al.   CURRENT MEDICINAL CHEMISTRY

Unusual Reactions of (+)-Car-2-ene and (+)-Car-3-ene with Aldehydes on K10 Clay

(2010) Irina V. Il'ina et al.   HELVETICA CHIMICA ACTA

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Benchmarking the Reliability of QikProp. Correlation between Experimental and Predicted Values

(2007) Leukothea Ioakimidis et al.   Quantitative structure-activity relationships & combinatorial science