Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer

The multifaceted role of glutathione S-transferases in cancer

(2018) Anupam Chatterjee et al.   CANCER LETTERS

Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health

(2018) Jun Zou et al.   Cell Host & Microbe

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Immune regulation by microbiome metabolites

(2018) Chang H. Kim   IMMUNOLOGY

Colonic aberrant crypt formation accompanies an increase of opportunistic pathogenic bacteria in C57BL/6 mice fed a high-fat diet

(2018) Huawei Zeng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The role of the lipidome in obesity-mediated colon cancer risk

(2018) Raghav Jain et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

(2018) Christina M. van der Beek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells

(2018) Camille Martin-Gallausiaux et al.   Scientific Reports

The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It

(2018) Heather Armstrong et al.   Cancers

Dietary fiber intake and risks of proximal and distal colon cancers

(2018) Yu Ma et al.   MEDICINE

Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation

(2018) Knud Bach Knudsen et al.   Nutrients

Dietary saturated fatty acid type impacts obesity-induced metabolic dysfunction and plasma lipidomic signatures in mice

(2018) Petr Žáček et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway

(2017) Jin-Lu Wu et al.   IMMUNOLOGY LETTERS

Wnt proteins synergize to activate β-catenin signaling

(2017) Anshula Alok et al.   JOURNAL OF CELL SCIENCE

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

(2017) Leon Zheng et al.   JOURNAL OF IMMUNOLOGY

Bile acids and colon cancer: Is FXR the solution of the conundrum?

(2017) Raffaella Maria Gadaleta et al.   MOLECULAR ASPECTS OF MEDICINE

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

(2017) Christina M. van der Beek et al.   NUTRITION REVIEWS

Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health

(2017) et al.   Nutrients

Butyrate Inhibits Cancerous HCT116 Colon Cell Proliferation but to a Lesser Extent in Noncancerous NCM460 Colon Cells

(2017) Huawei Zeng et al.   Nutrients

Relationship of the Reported Intakes of Fat and Fatty Acids to Body Weight in US Adults

(2017) Susan Raatz et al.   Nutrients

Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance

(2017) Sean McNabney et al.   Nutrients

Transforming growth factor-β: A therapeutic target for cancer

(2017) Sulsal Haque et al.   Human Vaccines & Immunotherapeutics

Linking Gut Microbiota to Colorectal Cancer

(2017) Hans Raskov et al.   Journal of Cancer

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

(2017) Meike Kespohl et al.   Frontiers in Immunology

Hyperinduction of Wnt Activity: A New Paradigm for the Treatment of Colorectal Cancer?

(2017) Michael Bordonaro et al.   ONCOLOGY RESEARCH

Bile Acid Recognition by NAPE-PLD

(2016) Eleonora Margheritis et al.   ACS Chemical Biology

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

(2016) Christopher Staley et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis

(2016) Raffaele Simeoli et al.   BRITISH JOURNAL OF PHARMACOLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

The Intestinal Immune System in Obesity and Insulin Resistance

(2016) Daniel A. Winer et al.   Cell Metabolism

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat β-glucan

(2016) Purnima Gunness et al.   FASEB JOURNAL

Intestinal alkaline phosphatase and sodium butyrate may be beneficial in attenuating LPS-induced intestinal inflammation

(2016) A.D.B. Melo et al.   GENETICS AND MOLECULAR RESEARCH

Butyrate suppresses murine mast cell proliferation and cytokine production through inhibiting histone deacetylase

(2016) Hanying Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Colonic inflammation accompanies an increase of β-catenin signaling and Lachnospiraceae / Streptococcaceae bacteria in the hind gut of high-fat diet-fed mice

(2016) Huawei Zeng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Plasma membrane-bound G protein-coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll-like receptor 4 signaling in mice

(2016) Haojun Yang et al.   LIVER TRANSPLANTATION

Circulating triglycerides and bile acids are reduced by a soluble wheat arabinoxylan via modulation of bile concentration and lipid digestion rates in a pig model

(2016) Purnima Gunness et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

High-fat Western diet–induced obesity contributes to increased tumor growth in mouse models of human colon cancer

(2016) Ann Marie O'Neill et al.   NUTRITION RESEARCH

Linking the Microbiota, Chronic Disease, and the Immune System

(2016) Timothy W. Hand et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Bile acid: a potential inducer of colon cancer stem cells

(2016) Lulu Farhana et al.   Stem Cell Research & Therapy

Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

(2016) Audrey Rivière et al.   Frontiers in Microbiology

Colorectal cancer development and advances in screening

(2016) Vanessa Balchen et al.   Clinical Interventions in Aging

Inflammatory and Non-Inflammatory Roles for Toll-Like Receptors in Gastrointestinal Cancer

(2015) Alison West et al.   CURRENT PHARMACEUTICAL DESIGN

High-fat Diet-induced Intestinal Hyperpermeability is Associated with Increased Bile Acids in the Large Intestine of Mice

(2015) Yuki Murakami et al.   JOURNAL OF FOOD SCIENCE

Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation

(2015) Huawei Zeng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Structure of Human N -Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids

(2015) Paola Magotti et al.   STRUCTURE

CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer

(2015) Michael Bordonaro   WORLD JOURNAL OF GASTROENTEROLOGY

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

(2015) Lucie Geurts et al.   Nature Communications

Microbiota disbiosis is associated with colorectal cancer

(2015) Zhiguang Gao et al.   Frontiers in Microbiology

Microbes, Microbiota, and Colon Cancer

(2014) Cynthia L. Sears et al.   Cell Host & Microbe

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Diet, Microbiota, and Colorectal Cancer

(2014) Hakan Akin et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer

(2014) Jiřina Hofmanová et al.   MEDIATORS OF INFLAMMATION

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Secondary bile acids: an underrecognized cause of colon cancer

(2014) Hana Ajouz et al.   World Journal of Surgical Oncology

Shaping macrophages function and innate immunity by bile acids: Mechanisms and implication in cholestatic liver diseases

(2014) Yvon Calmus et al.   Clinics and Research in Hepatology and Gastroenterology

Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention

(2014) Huawei Zeng   World Journal of Gastrointestinal Oncology

FXR silencing in human colon cancer by DNA methylation and KRAS signaling

(2013) Ann M. Bailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular Pathways: Gene-Environment Interactions Regulating Dietary Fiber Induction of Proliferation and Apoptosis via Butyrate for Cancer Prevention

(2013) S. J. Bultman   CLINICAL CANCER RESEARCH

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

(2013) Barbara Renga et al.   PLoS One

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CBP Activity Mediates Effects of the Histone Deacetylase Inhibitor Butyrate on WNT Activity and Apoptosis in Colon Cancer Cells

(2013) Darina L Lazarova et al.   Journal of Cancer

An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development

(2013) Bruce M. Boman et al.   Frontiers in Oncology

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells

(2012) Mary A. Zimmerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression of bile acid receptor TGR5 in gastric adenocarcinoma

(2012) Weibiao Cao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate

(2012) Kim Y. C. Fung et al.   BRITISH JOURNAL OF NUTRITION

Emerging avenues linking inflammation and cancer

(2012) Joydeb Kumar Kundu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

(2012) Harold Tjalsma et al.   NATURE REVIEWS MICROBIOLOGY

Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes

(2012) Dallas R. Donohoe et al.   PLoS One

Dietary fiber enhances TGF-β signaling and growth inhibition in the gut

(2011) Yanna Cao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Carcinogenicity of deoxycholate, a secondary bile acid

(2011) Carol Bernstein et al.   ARCHIVES OF TOXICOLOGY

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine

(2011) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TGF-beta signalling in colon carcinogenesis

(2011) Pavlos Lampropoulos et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?

(2011) Michael Bordonaro et al.   CELL CYCLE

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Distinct Compartmentalization of NF-κB Activity in Crypt and Crypt-Denuded Lamina Propria Precedes and Accompanies Hyperplasia and/or Colitis following Bacterial Infection

(2011) Parthasarathy Chandrakesan et al.   INFECTION AND IMMUNITY

Intestinal Microecology in Health and Wellness

(2011) Martin H. Floch   JOURNAL OF CLINICAL GASTROENTEROLOGY

Fermentation in the Human Large Intestine

(2011) George T. Macfarlane et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose

(2011) Kaisa Raninen et al.   NUTRITION REVIEWS

A Switch from Canonical to Noncanonical Wnt Signaling Mediates Drug Resistance in Colon Cancer Cells

(2011) Michael Bordonaro et al.   PLoS One

Bile acids and colon cancer: Solving the puzzle with nuclear receptors

(2011) Chiara Degirolamo et al.   TRENDS IN MOLECULAR MEDICINE

Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease

(2010) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

AKR1B7 Is Induced by the Farnesoid X Receptor and Metabolizes Bile Acids

(2010) Daniel R. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting thein VivoMetabolic Potential of Two Human Gut Acetogens

(2010) Federico E. Rey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspective: Alpha-Bugs, Their Microbial Partners, and the Link to Colon Cancer

(2010) Cynthia L. Sears et al.   JOURNAL OF INFECTIOUS DISEASES

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm

(2010) J. Walter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile acids: short and long term effects in the intestine

(2010) Antal Bajor et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Dietary Fiber Supplements: Effects in Obesity and Metabolic Syndrome and Relationship to Gastrointestinal Functions

(2009) Athanasios Papathanasopoulos et al.   GASTROENTEROLOGY

The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis

(2009) A. Mencarelli et al.   JOURNAL OF IMMUNOLOGY

Bile acids: regulation of apoptosis by ursodeoxycholic acid

(2009) Joana D. Amaral et al.   JOURNAL OF LIPID RESEARCH

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability

(2009) M Krishnan et al.   ONCOGENE

Nuclear Bile Acid Receptor FXR Protects against Intestinal Tumorigenesis

(2008) S. Modica et al.   CANCER RESEARCH

Molecular Epidemiology and Phylogenetic Distribution of the Escherichia coli pks Genomic Island

(2008) J. R. Johnson et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Position of the American Dietetic Association: Health Implications of Dietary Fiber

(2008)   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION