Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease

Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation

(2019) Sebastian Zundler et al.   NATURE IMMUNOLOGY

CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses

(2019) Lalit K. Beura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident memory CD8 T cells persist for years in human small intestine

(2019) Raquel Bartolomé-Casado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Current best practices in single‐cell RNA‐seq analysis: a tutorial

(2019) Malte D Luecken et al.   Molecular Systems Biology

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

(2019) Chaofan Li et al.   IMMUNITY

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

(2019) Simone L. Park et al.   TRENDS IN IMMUNOLOGY

Functional interpretation of single cell similarity maps

(2019) David DeTomaso et al.   Nature Communications

Tumor-reprogrammed resident T cells resist radiation to control tumors

(2019) Ainhoa Arina et al.   Nature Communications

Distinct Regulatory and Effector T Cell Metabolic Demands during Graft-Versus-Host Disease

(2019) Keli L. Hippen et al.   TRENDS IN IMMUNOLOGY

T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage

(2019) S. Takashima et al.   Science Immunology

Tissue-resident memory T cells at the center of immunity to solid tumors

(2018) Derk Amsen et al.   NATURE IMMUNOLOGY

Peripheral Tissue Chemokines: Homeostatic Control of Immune Surveillance T Cells

(2018) Michelle L. McCully et al.   TRENDS IN IMMUNOLOGY

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

(2018) Henrique Borges da Silva et al.   NATURE

Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells

(2018) Felix M. Behr et al.   Frontiers in Immunology

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

(2018) Lei Zhang et al.   NATURE

Cytotoxic Pathways in Allogeneic Hematopoietic Cell Transplantation

(2018) Wei Du et al.   Frontiers in Immunology

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

(2017) Leslie S. Kean et al.   IMMUNOLOGICAL REVIEWS

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Ensembl 2018

(2017) Daniel R Zerbino et al.   NUCLEIC ACIDS RESEARCH

Combined OX40L and mTOR blockade controls effector T cell activation while preserving T reg reconstitution after transplant

(2017) Victor Tkachev et al.   Science Translational Medicine

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

(2017) Andrea Romagnani et al.   Nature Communications

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

Implications of Resident Memory T Cells for Transplantation

(2016) L. K. Beura et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

(2016) Scott N. Furlan et al.   BLOOD

Pathogenesis of acute graft-versus-host disease: from intestinal microbiota alterations to donor T cell activation

(2016) Robert Zeiser et al.   BRITISH JOURNAL OF HAEMATOLOGY

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets

(2016) Yuan Tian et al.   JOURNAL OF IMMUNOLOGY

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

(2016) C. Colin Brinkman et al.   Nature Communications

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection

(2015) Tessa Bergsbaken et al.   NATURE IMMUNOLOGY

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis

(2015) Seong-Hye Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention

(2015) Scott N. Furlan et al.   Science Translational Medicine

T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors

(2015) Loïc Dupré et al.   Frontiers in Immunology

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Proteasome: target for acute and chronic GVHD?

(2014) J. M. Magenau et al.   BLOOD

Id2 represses E2A-mediated activation of IL-10 expression in T cells

(2014) F. Masson et al.   BLOOD

Potential limitations of IL-2 administration for the treatment of experimental acute graft-versus-host disease

(2014) Louis Pérol et al.   IMMUNOLOGY LETTERS

Coactosin-Like 1 Antagonizes Cofilin to Promote Lamellipodial Protrusion at the Immune Synapse

(2014) Joanna Kim et al.   PLoS One

NK cell intrinsic regulation of MIP-1α by granzyme M

(2014) N Baschuk et al.   Cell Death & Disease

Effector T cells require fatty acid metabolism during murine graft-versus-host disease

(2013) C. A. Byersdorfer et al.   BLOOD

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

The role of cyclase-associated protein in regulating actin filament dynamics - more than a monomer-sequestration factor

(2013) S. Ono   JOURNAL OF CELL SCIENCE

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses

(2012) K. G. Anderson et al.   JOURNAL OF IMMUNOLOGY

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease

(2012) Ran Reshef et al.   NEW ENGLAND JOURNAL OF MEDICINE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients

(2012) R. A. Clark et al.   Science Translational Medicine

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

(2011) K. L. Hippen et al.   BLOOD

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

(2011) A. M. Hanash et al.   BLOOD

ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells

(2011) Shyamal D Desai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cutting Edge: Regulator of G Protein Signaling-1 Selectively Regulates Gut T Cell Trafficking and Colitic Potential

(2011) D. L. Gibbons et al.   JOURNAL OF IMMUNOLOGY

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease

(2011) E. Gatza et al.   Science Translational Medicine

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

(2010) W. P. Miller et al.   BLOOD

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The CCL3/Macrophage Inflammatory Protein-1α–Binding Protein Evasin-1 Protects from Graft-versus-Host Disease but Does Not Modify Graft-versus-Leukemia in Mice

(2010) Marina G. M. Castor et al.   JOURNAL OF IMMUNOLOGY

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

(2009) C. Bucher et al.   BLOOD

Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells

(2008) B. E. Anderson et al.   BLOOD

Predominant donor CD103+CD8+ T cell infiltration into the gut epithelium during acute GvHD: a role of gut lymph nodes

(2008) Shu Zhou et al.   INTERNATIONAL IMMUNOLOGY

2 integrins separate graft-versus-host disease and graft-versus-leukemia effects

(2007) Y. Liang et al.   BLOOD