A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets

IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis

(2015) Youjin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-21 Is Important for Induction of KLRG1+Effector CD8 T Cells during Acute Intracellular Infection

(2015) Magali M. Moretto et al.   JOURNAL OF IMMUNOLOGY

Dengue virus infection elicits highly polarized CX3CR1+cytotoxic CD4+T cells associated with protective immunity

(2015) Daniela Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional classification of memory CD8+ T cells by CX3CR1 expression

(2015) Jan P. Böttcher et al.   Nature Communications

Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs

(2014) J. M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

(2014) N. Iijima et al.   SCIENCE

IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet

(2013) A. P. R. Sutherland et al.   JOURNAL OF IMMUNOLOGY

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation

(2013) J Adam Best et al.   NATURE IMMUNOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

A vaccine strategy that protects against genital herpes by establishing local memory T cells

(2012) Haina Shin et al.   NATURE

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

(2012) Nu Zhang et al.   NATURE IMMUNOLOGY

Anti-viral CD8 T cells and the cytokines that they love

(2012) Maureen A. Cox et al.   VIROLOGY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Intrinsic IL-21 Signaling Is Critical for CD8 T Cell Survival and Memory Formation in Response to Vaccinia Viral Infection

(2011) P. Novy et al.   JOURNAL OF IMMUNOLOGY

CD8+ T Effector Memory Cells Protect against Liver-Stage Malaria

(2011) A. Reyes-Sandoval et al.   JOURNAL OF IMMUNOLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses

(2010) Brianne R. Barker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 Deficiency Influences CD8 T Cell Quality and Recall Responses following an Acute Viral Infection

(2010) J. S. Yi et al.   JOURNAL OF IMMUNOLOGY

Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection

(2010) Y. W. Jung et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21: a multifunctional regulator of immunity to infections

(2010) John S. Yi et al.   MICROBES AND INFECTION

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

(2008) C. S. Hinrichs et al.   BLOOD

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

Small intestinal CD103+dendritic cells display unique functional properties that are conserved between mice and humans

(2008) Elin Jaensson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology