Developmental cell programs are co-opted in inflammatory skin disease

Deciphering the functional heterogeneity of skin fibroblasts using single‐cell RNA sequencing

(2020) Vera Vorstandlechner et al.   FASEB JOURNAL

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

(2020) Helen He et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A cell atlas of human thymic development defines T cell repertoire formation

(2020) Jong-Eun Park et al.   SCIENCE

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

(2020) Jermaine Goveia et al.   CANCER CELL

Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis

(2020) Thomas B. Rojahn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Prostate cancer reactivates developmental epigenomic programs during metastatic progression

(2020) Mark M. Pomerantz et al.   NATURE GENETICS

Huntington’s disease alters human neurodevelopment

(2020) Monia Barnat et al.   SCIENCE

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

(2020) Llorenç Solé-Boldo et al.   Communications Biology

Atopic dermatitis is an IL-13 dominant disease with greater molecular heterogeneity compared to psoriasis

(2019) Lam C. Tsoi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Single-Cell Analysis Reveals Heterogeneity of High Endothelial Venules and Different Regulation of Genes Controlling Lymphocyte Entry to Lymph Nodes

(2019) Krystle Veerman et al.   Cell Reports

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Identification of HIV transmitting CD11c+ human epidermal dendritic cells

(2019) Kirstie M. Bertram et al.   Nature Communications

Spectrum of ichthyoses in an Austrian ichthyosis cohort from 2004 to 2017

(2019) Magdalena Seidl‐Philipp et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors

(2019) Dan Xue et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Decoding human fetal liver haematopoiesis

(2019) Dorin-Mirel Popescu et al.   NATURE

Stalled developmental programs at the root of pediatric brain tumors

(2019) Selin Jessa et al.   NATURE GENETICS

Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer

(2019) Roshane Francis et al.   Science Advances

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+T cells

(2018) Kyla D. Omilusik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

(2018) Tracy Tabib et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CD96 expression determines the inflammatory potential of IL-9–producing Th9 cells

(2018) Katarina Stanko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway

(2018) Tsing-Lee Tang-Huau et al.   Nature Communications

Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution

(2018) Jeffrey B. Cheng et al.   Cell Reports

T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node

(2017) Myriam Baratin et al.   IMMUNITY

Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes

(2017) Rachel A. Botting et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse

(2017) Cynthia L Smith et al.   NUCLEIC ACIDS RESEARCH

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

(2017) Ajay Mishra et al.   eLife

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

(2016) Laurence Ardouin et al.   IMMUNITY

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

NK cells and type 1 innate lymphoid cells: partners in host defense

(2016) Hergen Spits et al.   NATURE IMMUNOLOGY

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

(2016) Gerd Meyer zu Horste et al.   Cell Reports

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

(2016) Simon Joost et al.   Cell Systems

Transcriptional Analysis of T Cells Resident in Human Skin

(2016) Jane Li et al.   PLoS One

Enabling research with human embryonic and fetal tissue resources

(2015) D. Gerrelli et al.   DEVELOPMENT

Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice

(2015) Elisa Montaldo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

(2015) Jochem H. Bernink et al.   IMMUNITY

Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis

(2015) Dorothea Terhorst et al.   JOURNAL OF IMMUNOLOGY

SERPINB3/B4 Contributes to Early Inflammation and Barrier Dysfunction in an Experimental Murine Model of Atopic Dermatitis

(2015) Umasundari Sivaprasad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions

(2015) Thien-Phong Vu Manh et al.   Frontiers in Immunology

Human Dermal CD14 + Cells Are a Transient Population of Monocyte-Derived Macrophages

(2014) Naomi McGovern et al.   IMMUNITY

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones

(2014) R. Takagi et al.   JOURNAL OF IMMUNOLOGY

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Pharmacological Inhibition of TPL2/MAP3K8 Blocks Human Cytotoxic T Lymphocyte Effector Functions

(2014) Fatema Z. Chowdhury et al.   PLoS One

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3

(2013) Helia B. Schonthaler et al.   IMMUNITY

A Three-Dimensional Atlas of Human Dermal Leukocytes, Lymphatics, and Blood Vessels

(2013) Xiao-Nong Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Interleukin-33 Drives a Proinflammatory Endothelial Activation That Selectively Targets Nonquiescent Cells

(2012) Jürgen Pollheimer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases

(2012) W Wei et al.   GENES AND IMMUNITY

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lamellar Bodies: The Key to Cutaneous Barrier Function

(2012) Kenneth R. Feingold   JOURNAL OF INVESTIGATIVE DERMATOLOGY

DUSP4 deficiency enhances CD25 expression and CD4+T-cell proliferation without impeding T-cell development

(2011) Ching-Yu Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Disease Ontology: a backbone for disease semantic integration

(2011) L. M. Schriml et al.   NUCLEIC ACIDS RESEARCH

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Blimp Hovers over T Cell Immunity

(2009) Raymond M. Welsh   IMMUNITY

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation

(2009) Muzlifah Haniffa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

(2009) Laurent Chorro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis

(2009) Erin G. Harper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY