GRK5 is a regulator of fibroblast activation and cardiac fibrosis

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis

(2019) Alan J. Mouton et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association

(2019) Janani Rangaswami et al.   CIRCULATION

G protein-coupled receptor kinases as therapeutic targets in the heart

(2019) Jessica Pfleger et al.   Nature Reviews Cardiology

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

(2019) Tyler S. Beyett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

(2019) Alyssa A. Lombardi et al.   Nature Communications

Therapeutic approaches for cardiac regeneration and repair

(2018) Hisayuki Hashimoto et al.   Nature Reviews Cardiology

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging

(2018) Claudio de Lucia et al.   Frontiers in Pharmacology

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression

(2017) Joshua G. Travers et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)

(2017) Zheng Xu et al.   Scientific Reports

Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages

(2017) Thomas Moore-Morris et al.   CIRCULATION RESEARCH

Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion InjuryNovelty and Significance

(2016) Meryl C. Woodall et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin IINovelty and Significance

(2016) Takehiko Takayanagi et al.   HYPERTENSION

Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion

(2016) Yong Seon Choi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular networks underlying myofibroblast fate and fibrosis

(2016) April Stempien-Otero et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A peptide of the RGS domain of GRK2 binds and inhibits Gαqto suppress pathological cardiac hypertrophy and dysfunction

(2016) Sarah M. Schumacher et al.   Science Signaling

A peptide of the RGS domain of GRK2 binds and inhibits Gαqto suppress pathological cardiac hypertrophy and dysfunction

(2016) Sarah M. Schumacher et al.   Science Signaling

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease

(2015) Priscila Y. Sato et al.   PHYSIOLOGICAL REVIEWS

MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response

(2015) Jennifer Davis et al.   Nature Communications

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

(2014) Jonathan E. Hullmann et al.   CIRCULATION RESEARCH

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation

(2013) Fouad A Zouein et al.   HYPERTENSION RESEARCH

Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts

(2013) Adam C. Midgley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myofibroblasts: Trust your heart and let fate decide

(2013) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

(2013) Jessica I. Gold et al.   PLoS One

Distinct Structural Features of G Protein-Coupled Receptor Kinase 5 (GRK5) Regulate Its Nuclear Localization and DNA-Binding Ability

(2013) Laura R. Johnson et al.   PLoS One

Transforming Growth Factor–β Evokes Ca2+Waves and Enhances Gene Expression in Human Pulmonary Fibroblasts

(2012) Subhendu Mukherjee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Determining the Absolute Requirement of G Protein–Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy

(2012) Jessica I. Gold et al.   CIRCULATION RESEARCH

Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation

(2012) Jun Mori et al.   Circulation-Heart Failure

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

(2012) Jennifer Davis et al.   DEVELOPMENTAL CELL

Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts

(2012) Aaron N. Snead et al.   FASEB JOURNAL

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

(2012) Kate M. Herum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals

(2012) Ravi K. Adapala et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E–Deficient Mice

(2011) Kimio Satoh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

(2010) Henriette Brinks et al.   CIRCULATION RESEARCH

TRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation

(2010) Jianyang Du et al.   CIRCULATION RESEARCH

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

(2010) Erhe Gao et al.   CIRCULATION RESEARCH

Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2

(2010) JiuChang Zhong et al.   HYPERTENSION

Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts

(2009) Xiuren Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pravastatin Attenuates Left Ventricular Remodeling and Diastolic Dysfunction in Angiotensin II-Induced Hypertensive Mice

(2009) Zhujie Xu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA