Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)

MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

(2016) Jibo Han et al.   BASIC RESEARCH IN CARDIOLOGY

Angiotensin-(1–7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways

(2016) Feng Zhang et al.   Scientific Reports

MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis

(2015) Yi Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin Ⅱ Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4

(2015) Susumu Matsuda et al.   Journal of Atherosclerosis and Thrombosis

A novel chalcone derivative attenuates the diabetes-induced renal injury via inhibition of high glucose-mediated inflammatory response and macrophage infiltration

(2015) Qilu Fang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Toll-like receptors in diabetic nephropathy

(2014) Harshini Mudaliar et al.   CLINICAL SCIENCE

TLR4 Activation Promotes Podocyte Injury and Interstitial Fibrosis in Diabetic Nephropathy

(2014) Jin Ma et al.   PLoS One

MD-2 as the Target of Nonlipid Chalcone in the Inhibition of Endotoxin LPS-Induced TLR4 Activity

(2011) Eunmiri Roh et al.   JOURNAL OF INFECTIOUS DISEASES

Evaluation and Discovery of Novel Synthetic Chalcone Derivatives as Anti-Inflammatory Agents

(2011) Jianzhang Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

(2011) M. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal TLR4 mRNA Expression Correlates with Inflammatory Marker MCP-1 and Profibrotic Molecule TGF-β1 in Patients with Chronic Kidney Disease

(2011) Julia Lepenies et al.   NEPHRON CLINICAL PRACTICE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation

(2010) M. Koc et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Angiotensin II Induces Inflammatory Response Partly Via Toll-Like Receptor 4-Dependent Signaling Pathway in Vascular Smooth Muscle Cells

(2009) Yuanyuan Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY