Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts

cAMP and Epac in the regulation of tissue fibrosis

(2012) Paul A Insel et al.   BRITISH JOURNAL OF PHARMACOLOGY

ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors

(2012) David Lu et al.   FASEB JOURNAL

Endothelin and endothelin receptors in the renal and cardiovascular systems

(2012) Nicolas Vignon-Zellweger et al.   LIFE SCIENCES

PAI-1 in tissue fibrosis

(2011) Asish K. Ghosh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Angiotensin II as a Morphogenic Cytokine Stimulating Renal Fibrogenesis

(2011) C. Ruster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

The Coagulation System Contributes to αVβ6 Integrin Expression and Liver Fibrosis Induced by Cholestasis

(2010) Bradley P. Sullivan et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts

(2010) Hilde Laeremans et al.   CARDIOVASCULAR RESEARCH

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Role of protease-activated receptors in human skin fibrosis and scleroderma

(2010) Ferda Cevikbas et al.   EXPERIMENTAL DERMATOLOGY

Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors

(2010) Oscar Ö. Braun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model

(2009) John E. Baker et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Proteases Display Biased Agonism at Protease-Activated Receptors: Location matters!

(2009) A. Russo et al.   MOLECULAR INTERVENTIONS

Identification of Potential Pharmacological Targets by Analysis of the Comprehensive G Protein-Coupled Receptor Repertoire in the Four Cardiac Chambers

(2009) T. Moore-Morris et al.   MOLECULAR PHARMACOLOGY

Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?

(2008) R C Chambers   BRITISH JOURNAL OF PHARMACOLOGY

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Protein Kinase D Links Gq-coupled Receptors to cAMP Response Element-binding Protein (CREB)-Ser133Phosphorylation in the Heart

(2008) Nazira Ozgen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors

(2008) Richard Einstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA