A peptide of the RGS domain of GRK2 binds and inhibits Gαqto suppress pathological cardiac hypertrophy and dysfunction

The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease

(2015) Priscila Y. Sato et al.   PHYSIOLOGICAL REVIEWS

Myocardial remodeling in hypertension

(2014) W Nadruz   JOURNAL OF HUMAN HYPERTENSION

Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-G βγ Inhibition Halts Heart Failure Progression

(2014) Fadia A. Kamal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

(2014) T. Justin Rettenmaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

(2013) Mai Chen et al.   CIRCULATION RESEARCH

Gene therapy clinical trials worldwide to 2012 - an update

(2013) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

(2013) Qian Fan et al.   PLoS One

Convergence of G Protein-Coupled Receptor and S-Nitrosylation Signaling Determines the Outcome to Cardiac Ischemic Injury

(2013) Z. M. Huang et al.   Science Signaling

Strike a pose: Gαq complexes at the membrane

(2013) Angeline M. Lyon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

AAV6. ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

(2012) P. W. J. Raake et al.   EUROPEAN HEART JOURNAL

GRK2: multiple roles beyond G protein-coupled receptor desensitization

(2012) Tama Evron et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Progression of Hypertensive Heart Disease

(2011) Mark H. Drazner   CIRCULATION

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

(2010) Petronila Penela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

(2010) Henriette Brinks et al.   CIRCULATION RESEARCH

Small Molecule Disruption of Gβγ Signaling Inhibits the Progression of Heart Failure

(2010) Liam M. Casey et al.   CIRCULATION RESEARCH

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

(2010) Erhe Gao et al.   CIRCULATION RESEARCH

Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies

(2010) Bianca C. Bernardo et al.   PHARMACOLOGY & THERAPEUTICS

Myocardial Adeno-Associated Virus Serotype 6–βARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure

(2008) Giuseppe Rengo et al.   CIRCULATION

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA