The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease

Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-G βγ Inhibition Halts Heart Failure Progression

(2014) Fadia A. Kamal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

GRK5 Intronic (CA)n Polymorphisms Associated with Type 2 Diabetes in Chinese Hainan Island

(2014) Zhenfang Xia et al.   PLoS One

Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats

(2013) Wenjuan Xing et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

State of the art paper The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology

(2013) Tijana Bojic et al.   Archives of Medical Science

Endothelial G Protein–Coupled Receptor Kinase 2 Regulates Vascular Homeostasis Through the Control of Free Radical Oxygen Species

(2013) Michele Ciccarelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

(2013) Mai Chen et al.   CIRCULATION RESEARCH

Adrenergic Nervous System in Heart Failure

(2013) Anastasios Lymperopoulos et al.   CIRCULATION RESEARCH

No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort

(2013) Gemma A. Figtree et al.   EUROPEAN JOURNAL OF HEART FAILURE

Increased Nitric Oxide Bioavailability in Adult GRK2 Hemizygous Mice Protects Against Angiotensin II–Induced Hypertension

(2013) María S. Avendaño et al.   HYPERTENSION

Regulation of Nuclear Factor κB (NF-κB) in the Nucleus of Cardiomyocytes by G Protein-coupled Receptor Kinase 5 (GRK5)

(2013) Kazi N. Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR4 Signaling Augments Monocyte Chemotaxis by Regulating G Protein-Coupled Receptor Kinase 2 Translocation

(2013) Z. Liu et al.   JOURNAL OF IMMUNOLOGY

G-Protein-Coupled Receptor Kinase-5 Mediates Inflammation but Does Not Regulate Cellular Infiltration or Bacterial Load in a Polymicrobial Sepsis Model in Mice

(2013) Nandakumar Packiriswamy et al.   Journal of Innate Immunity

G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis

(2013) N. L. Stevenson et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

(2013) Jessica I. Gold et al.   PLoS One

Distinct Structural Features of G Protein-Coupled Receptor Kinase 5 (GRK5) Regulate Its Nuclear Localization and DNA-Binding Ability

(2013) Laura R. Johnson et al.   PLoS One

Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

(2013) Qian Fan et al.   PLoS One

Convergence of G Protein-Coupled Receptor and S-Nitrosylation Signaling Determines the Outcome to Cardiac Ischemic Injury

(2013) Z. M. Huang et al.   Science Signaling

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

(2013) Michio Nakaya et al.   Nature Communications

Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking

(2013) Martin D. Burkhalter et al.   Cell Reports

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

(2012) David M. Thal et al.   ACS Chemical Biology

Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure ethiology and correlates to clinical variables

(2012) Fermí Montó et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload

(2012) Thomas G. von Lueder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca 2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

(2012) Philip W. Raake et al.   CIRCULATION

Determining the Absolute Requirement of G Protein–Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy

(2012) Jessica I. Gold et al.   CIRCULATION RESEARCH

AAV6. ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

(2012) P. W. J. Raake et al.   EUROPEAN HEART JOURNAL

G protein receptor kinase 4 polymorphisms

(2012) Alexander G. Vandell et al.   HYPERTENSION

Pooled Analyses of the Associations of Polymorphisms in the GRK4 and EMILIN1 Genes with Hypertension Risk

(2012) Chibo Liu et al.   International Journal of Medical Sciences

Involvement of Nuclear Factor κB (NF-κB) Signaling Pathway in Regulation of Cardiac G Protein-coupled Receptor Kinase 5 (GRK5) Expression

(2012) Kazi N. Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenergic-Pathway Gene Variants Influence Beta-Blocker–Related Outcomes After Acute Coronary Syndrome in a Race-Specific Manner

(2012) Sharon Cresci et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

G Protein-Coupled Receptor Kinase 2 in Patients With Acute Myocardial Infarction

(2011) Gaetano Santulli et al.   AMERICAN JOURNAL OF CARDIOLOGY

Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: A potential link to stress resilience

(2011) Manish Taneja et al.   BEHAVIOURAL BRAIN RESEARCH

Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain

(2011) Chih-chin Huang et al.   BIOCHEMISTRY

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis

(2011) Anna Fusco et al.   CELLULAR SIGNALLING

G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

(2011) Michele Ciccarelli et al.   CIRCULATION

G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease

(2011) Stephen L. Belmonte et al.   CIRCULATION RESEARCH

Nuclear Effects of G-Protein Receptor Kinase 5 on Histone Deacetylase 5–Regulated Gene Transcription in Heart Failure

(2011) Yan Zhang et al.   Circulation-Heart Failure

G protein-coupled receptor kinases in normal and failing myocardium

(2011) Zheng Maggie Huang   Frontiers in Bioscience-Landmark

Recognition in the Face of Diversity: Interactions of Heterotrimeric G proteins and G Protein-coupled Receptor (GPCR) Kinases with Activated GPCRs

(2011) Chih-chin Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardial G Protein Receptor–Coupled Kinase Expression Correlates With Functional Parameters and Clinical Severity in Advanced Heart Failure

(2011) Jaime Agüero et al.   JOURNAL OF CARDIAC FAILURE

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model

(2011) Kumiko Taguchi et al.   PHARMACOLOGICAL RESEARCH

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease

(2010) Patrizia Tarantino et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

(2010) Henriette Brinks et al.   CIRCULATION RESEARCH

The Inotropic Peptide βARKct Improves βAR Responsiveness in Normal and Failing Cardiomyocytes Through G βγ -Mediated L-Type Calcium Current Disinhibition

(2010) Mirko Völkers et al.   CIRCULATION RESEARCH

Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans

(2010) Maria P. Martinez Cantarin et al.   CTS-Clinical and Translational Science

Molecular basis for activation of G protein-coupled receptor kinases

(2010) Cassandra A Boguth et al.   EMBO JOURNAL

Intracardiac Injection of AdGRK5-NT Reduces Left Ventricular Hypertrophy by Inhibiting NF-κB–Dependent Hypertrophic Gene Expression

(2010) Daniela Sorriento et al.   HYPERTENSION

Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction

(2010) Anastasios Lymperopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gαq-mediated Activation of GRK2 by Mechanical Stretch in Cardiac Myocytes

(2010) Ricky Malhotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice

(2010) Sonika Patial et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF- B Signaling

(2010) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients

(2010) Maximilian T. Lobmeyer et al.   Pharmacogenetics and Genomics

 -Arrestin-Biased Agonism of the Angiotensin Receptor Induced by Mechanical Stress

(2010) K. Rakesh et al.   Science Signaling

G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

(2009) Sonika Patial et al.   BIOCHEMICAL JOURNAL

Role of the Amino Terminus of G Protein-Coupled Receptor Kinase 2 in Receptor Phosphorylation

(2009) Christina S. Pao et al.   BIOCHEMISTRY

GRK2 Activation by Receptors: Role of the Kinase Large Lobe and Carboxyl-Terminal Tail

(2009) Rachel Sterne-Marr et al.   BIOCHEMISTRY

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

(2009) Ersilia Cipolletta et al.   CARDIOVASCULAR RESEARCH

L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome

(2009) Letizia Spinelli et al.   EUROPEAN JOURNAL OF HEART FAILURE

Caveolin-1 and Dopamine-Mediated Internalization of NaKATPase in Human Renal Proximal Tubule Cells

(2009) John J. Gildea et al.   HYPERTENSION

G Protein–Coupled Receptor Kinase 2 Expression and Activity Are Associated With Blood Pressure in Black Americans

(2009) Heather I. Cohn et al.   HYPERTENSION

A Surface of the Kinase Domain Critical for the Allosteric Activation of G Protein-coupled Receptor Kinases

(2009) Chih-chin Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestin Mediates β1-Adrenergic Receptor-Epidermal Growth Factor Receptor Interaction and Downstream Signaling

(2009) Douglas G. Tilley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G Protein-coupled Receptor Kinase 4 (GRK4) Regulates the Phosphorylation and Function of the Dopamine D3Receptor

(2009) Van Anthony M. Villar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardial and Peripheral Lymphocytic Transcriptomic Dissociation of β-adrenoceptors and G Protein–coupled Receptor Kinases in Heart Transplantation

(2009) Jaime Agüero et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Role for the Regulator of G-Protein Signaling Homology Domain of G Protein-Coupled Receptor Kinases 5 and 6 in  2-Adrenergic Receptor and Rhodopsin Phosphorylation

(2009) F. Baameur et al.   MOLECULAR PHARMACOLOGY

A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of β2-adrenergic receptors

(2009) Wayne C.H. Wang et al.   Pharmacogenetics and Genomics

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myocardial Adeno-Associated Virus Serotype 6–βARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure

(2008) Giuseppe Rengo et al.   CIRCULATION

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

(2008) Philip W. Raake et al.   CIRCULATION RESEARCH

Gene Therapy in Heart Failure

(2008) Leif Erik Vinge et al.   CIRCULATION RESEARCH

GPCR signalling in hypertension: role of GRKs

(2008) David M. Harris et al.   CLINICAL SCIENCE

Enhanced GRK2 Expression and Desensitization of βAR Vasodilatation in Hypertensive Patients

(2008) Raffaele Izzo et al.   CTS-Clinical and Translational Science

G protein-coupled receptor kinase 2 positively regulates epithelial cell migration

(2008) Petronila Penela et al.   EMBO JOURNAL

Modulation of Adrenal Catecholamine Secretion by In Vivo Gene Transfer and Manipulation of G Protein–coupled Receptor Kinase-2 Activity

(2008) Anastasios Lymperopoulos et al.   MOLECULAR THERAPY

A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure

(2008) Stephen B Liggett et al.   NATURE MEDICINE

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The G-protein-coupled receptor kinase 5 inhibits NF B transcriptional activity by inducing nuclear accumulation of I B 

(2008) D. Sorriento et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic disorder in scaffold proteins: Getting more from less

(2008) Marc S. Cortese et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Correlation Between Beta-Adrenoceptors and G-Protein-Coupled Receptor Kinases in Pretransplantation Heart Failure

(2008) J. Agüero et al.   TRANSPLANTATION PROCEEDINGS

Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia

(2006) E.R. Bychkov et al.   NEUROBIOLOGY OF AGING