Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

(2020) Courtney Ackeifi et al.   Science Translational Medicine

How I treat steroid-refractory acute graft-versus-host disease

(2020) Paul J. Martin   BLOOD

Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis

(2020) Julia K. Panzer et al.   JCI Insight

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

(2019) Kenichiro Furuyama et al.   NATURE

Beta cells in type 1 diabetes: mass and function; sleeping or dead?

(2019) Richard A. Oram et al.   DIABETOLOGIA

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro

(2019) Ayelet Lenz et al.   PLoS One

Advances in technology for management of type 1 diabetes

(2019) Roy W Beck et al.   LANCET

New Frontiers in the Treatment of Type 1 Diabetes

(2019) Jeremy T. Warshauer et al.   Cell Metabolism

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

(2018) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

(2018) Julie B. Sneddon et al.   Cell Stem Cell

Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic Ducts

(2018) Yuhan Wang et al.   MOLECULAR THERAPY

MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice

(2018) Mingfeng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Future for Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

(2018) Kayleigh M. van Megen et al.   Frontiers in Immunology

Low Level Insulin Content Within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes

(2018) Carol J. Lam et al.   DIABETES

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

(2018) Emily K. Sims et al.   DIABETES CARE

The challenge of modulating β-cell autoimmunity in type 1 diabetes

(2018) Mark A Atkinson et al.   Lancet Diabetes & Endocrinology

Ectopic expression ofPax4in pancreatic δ cells results in β-like cell neogenesis

(2017) Noémie Druelle et al.   JOURNAL OF CELL BIOLOGY

PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells

(2017) Xiong Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

(2017) Kelen C. R. Malmegrim et al.   Frontiers in Immunology

Use of hematopoietic cell transplants to achieve tolerance in patients with solid organ transplants

(2016) S. Strober   BLOOD

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

(2016) Tehila Dahan et al.   DIABETES

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

Growth factors and medium hyperglycemia induce Sox9+ductal cell differentiation into β cells in mice with reversal of diabetes

(2016) Mingfeng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells with surface expression of CD133 high CD71 low are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas

(2016) Liang Jin et al.   Stem Cell Research

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

(2015) Dietmar M.W. Zaiss et al.   IMMUNITY

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

(2015) Mark R. Rigby et al.   JOURNAL OF CLINICAL INVESTIGATION

Modern approaches to HLA-haploidentical blood or marrow transplantation

(2015) Christopher G. Kanakry et al.   Nature Reviews Clinical Oncology

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice

(2015) Limin Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis

(2014) F. D'Addio et al.   DIABETES

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

(2014) Weida Li et al.   NATURE BIOTECHNOLOGY

Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D): 12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial

(2014) Kurt J Griffin et al.   Lancet Diabetes & Endocrinology

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial: Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders

(2013) K. C. Herold et al.   DIABETES

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Mixed Chimerism and Growth Factors Augment   Cell Regeneration and Reverse Late-Stage Type 1 Diabetes

(2012) M. Wang et al.   Science Translational Medicine

Reprogramming of pancreatic exocrine cells towards a beta (β) cell character usingPdx1,Ngn3andMafA

(2011) Ersin Akinci et al.   BIOCHEMICAL JOURNAL

Progenitor cell domains in the developing and adult pancreas

(2011) Janel L. Kopp et al.   CELL CYCLE

Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice

(2011) J. Racine et al.   DIABETES

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen

(2008) N. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA