MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells

(2017) Xiong Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation

(2017) Nathaniel J. Schuldt et al.   JOURNAL OF IMMUNOLOGY

The Importance of Dendritic Cells in Maintaining Immune Tolerance

(2017) Cindy Audiger et al.   JOURNAL OF IMMUNOLOGY

Bridge between type 1 diabetes in mouse and man

(2017) Defu Zeng   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes

(2017) Moufida Ben Nasr et al.   Science Translational Medicine

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

(2017) Kelen C. R. Malmegrim et al.   Frontiers in Immunology

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

(2016) Aaron W. Michels et al.   DIABETES

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

(2016) James A. Pearson et al.   JOURNAL OF AUTOIMMUNITY

Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?

(2016) Anabelle Visperas et al.   JOURNAL OF IMMUNOLOGY

Genetic risk factors for type 1 diabetes

(2016) Flemming Pociot et al.   LANCET

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

(2016) Marije Baas et al.   eLife

Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease

(2015) Mark A. Atkinson et al.   DIABETES CARE

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice

(2015) Limin Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Mixed Chimerism Depletes Pre-existing and De Novo–Developed Autoreactive B Cells in Autoimmune NOD Mice

(2014) Jeremy J. Racine et al.   DIABETES

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes

(2014) J. W. McGinty et al.   DIABETES

PD-1 is not required for natural or peripherally induced regulatory T cells: Severe autoimmunity despite normal production of regulatory T cells

(2014) Kristofor K. Ellestad et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

(2014) W. Chen et al.   JOURNAL OF IMMUNOLOGY

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

MHC-Mismatched Chimerism Is Required for Induction of Transplantation Tolerance in Autoimmune Nonobese Diabetic Recipients

(2014) Miao Wang et al.   JOURNAL OF IMMUNOLOGY

MHC-Mismatched Mixed Chimerism Mediates Thymic Deletion of Cross-Reactive Autoreactive T Cells and Prevents Insulitis in Nonobese Diabetic Mice

(2014) Jeremy J. Racine et al.   JOURNAL OF IMMUNOLOGY

B7H1/CD80 Interaction Augments PD-1–Dependent T Cell Apoptosis and Ameliorates Graft-versus-Host Disease

(2014) Ruishu Deng et al.   JOURNAL OF IMMUNOLOGY

Insulitis in human type 1 diabetes: a comparison between patients and animal models

(2014) Peter In’t Veld   Seminars in Immunopathology

It's Time to Bring Dendritic Cell Therapy to Type 1 Diabetes

(2013) R. J. Creusot et al.   DIABETES

Pathogenic CD4+T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

(2013) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Dual Receptor T Cells Mediate Pathologic Alloreactivity in Patients with Acute Graft-Versus-Host Disease

(2013) G. P. Morris et al.   Science Translational Medicine

Breakdown in Peripheral Tolerance in Type 1 Diabetes in Mice and Humans

(2013) L. T. Jeker et al.   Cold Spring Harbor Perspectives in Medicine

Following the Fate of One Insulin-Reactive CD4 T cell

(2012) Georgia Fousteri et al.   DIABETES

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mixed Chimerism and Growth Factors Augment   Cell Regeneration and Reverse Late-Stage Type 1 Diabetes

(2012) M. Wang et al.   Science Translational Medicine

The role of interferon alpha in initiation of type I diabetes in the NOD mouse

(2011) Qing Li et al.   CLINICAL IMMUNOLOGY

Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice

(2011) J. Racine et al.   DIABETES

Cutting Edge: Vasostatin-1–Derived Peptide ChgA29–42 Is an Antigenic Epitope of Diabetogenic BDC2.5 T Cells in Nonobese Diabetic Mice

(2011) Enayat Nikoopour et al.   JOURNAL OF IMMUNOLOGY

Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients

(2011) T. Yi et al.   JOURNAL OF IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

Type 1 Diabetes Immunotherapy: Is the Glass Half Empty or Half Full?

(2011) K. C. Herold et al.   Science Translational Medicine

The Long and Winding Road to Understanding and Conquering Type 1 Diabetes

(2010) Pere Santamaria   IMMUNITY

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

(2010) Melissa Swiecki et al.   IMMUNOLOGICAL REVIEWS

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo

(2009) S. Chikuma et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

High PD-L1/CD86 Ratio on Plasmacytoid Dendritic Cells Correlates With Elevated T-Regulatory Cells in Liver Transplant Tolerance

(2009) Daisuke Tokita et al.   TRANSPLANTATION

In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease

(2008) D. Zhao et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease

(2008) Husein Hadeiba et al.   NATURE IMMUNOLOGY

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

(2008) A. M. D'Alise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-  initiates type 1 diabetes in nonobese diabetic mice

(2008) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE