How I treat steroid-refractory acute graft-versus-host disease

Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial

(2020) Madan Jagasia et al.   BLOOD

The gut microbiota and graft-versus-host disease

(2019) David N. Fredricks   JOURNAL OF CLINICAL INVESTIGATION

Outcomes and Predictors of Response in Steroid-Refractory Acute Graft-versus-Host Disease

(2019) Armin Rashidi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation

(2019) Ya-Yuan Fu et al.   IMMUNITY

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

(2019) Motoko Koyama et al.   IMMUNITY

FDA Approval Summary: Ruxolitinib for Treatment of Steroid‐Refractory Acute Graft‐Versus‐Host Disease

(2019) Donna Przepiorka et al.   ONCOLOGIST

MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

(2018) Hannah Major-Monfried et al.   BLOOD

Extracorporeal photopheresis is a valuable treatment option in steroid-refractory or steroid-dependent acute graft versus host disease—experience with three different approaches

(2018) Marietta Nygaard et al.   BONE MARROW TRANSPLANTATION

Extracorporeal photopheresis as second-line therapy for patients with acute graft-versus-host disease: does the number of cells treated matter?

(2018) Nina Worel et al.   TRANSFUSION

Characterization of monocyte subtypes regarding their phenotype and development in the context of graft-versus-host disease

(2018) Katharina Reinhardt-Heller et al.   TRANSPLANT IMMUNOLOGY

Transplant-Associated Thrombotic Microangiopathy Is a Multifactorial Disease Unresponsive to Immunosuppressant Withdrawal

(2018) Ang Li et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF–licensed myeloid cells

(2018) Sonia Tugues et al.   Science Translational Medicine

Repeated fecal microbiota transplantations attenuate diarrhea and lead to sustained changes in the fecal microbiota in acute, refractory gastrointestinal graft- versus -host-disease

(2017) Walter Spindelboeck et al.   HAEMATOLOGICA

R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

(2017) Eiko Hayase et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease

(2017) Jérôme Legoff et al.   NATURE MEDICINE

Acute graft-versus-host disease of the gut: considerations for the gastroenterologist

(2017) Steven Naymagon et al.   Nature Reviews Gastroenterology & Hepatology

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease

(2017) Gideon Steinbach et al.   PLoS One

Repeated fecal microbiota transplantations attenuate diarrhea and lead to sustained changes in the fecal microbiota in acute, refractory gastrointestinal graft- versus -host-disease

(2017) Walter Spindelboeck et al.   HAEMATOLOGICA

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

(2016) Scott N. Furlan et al.   BLOOD

Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut

(2016) K. Kakihana et al.   BLOOD

How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver

(2016) G. B. McDonald   BLOOD

A gradient of glucocorticoid sensitivity among helper T cell cytokines

(2016) Jesus Banuelos et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Extracorporeal Photopheresis for Treatment of Acute and Chronic Graft Versus Host Disease

(2016) Michele Malagola et al.   TRANSPLANTATION

A Refined Risk Score for Acute Graft-versus-Host Disease that Predicts Response to Initial Therapy, Survival, and Transplant-Related Mortality

(2015) Margaret L. MacMillan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

(2015) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey

(2015) R Zeiser et al.   LEUKEMIA

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

Humanized anti-CD25 monoclonal antibody treatment of steroid-refractory acute graft-versus-host disease: a Chinese single-center experience in a group of 64 patients

(2015) T Tao et al.   Blood Cancer Journal

Prognostic factors and outcomes of severe gastrointestinal GVHD after allogeneic hematopoietic cell transplantation

(2014) C Castilla-Llorente et al.   BONE MARROW TRANSPLANTATION

Extracorporeal photopheresis as second-line treatment for acute graft-versus-host disease: impact on six-month freedom from treatment failure

(2014) E. Das-Gupta et al.   HAEMATOLOGICA

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracorporeal Photopheresis versus Anticytokine Therapy as a Second-Line Treatment for Steroid-Refractory Acute GVHD: A Multicenter Comparative Analysis

(2013) Madan Jagasia et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Long-term follow-up of corticosteroid refractory acute GVHD treated with an Inolimomab-based algorithm: a single center experience

(2013) S Girerd et al.   BONE MARROW TRANSPLANTATION

High pre-transplant serum nitrate levels predict risk of acute steroid-refractory graft-versus-host disease in the absence of statin therapy

(2013) S. Dietrich et al.   HAEMATOLOGICA

First- and Second-Line Systemic Treatment of Acute Graft-versus-Host Disease: Recommendations of the American Society of Blood and Marrow Transplantation

(2012) Paul J. Martin et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Endothelial Vulnerability and Endothelial Damage Are Associated with Risk of Graft-versus-Host Disease and Response to Steroid Treatment

(2012) Sascha Dietrich et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system

(2011) T. Luft et al.   BLOOD

The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

(2011) Shuichiro Takashima et al.   JOURNAL OF EXPERIMENTAL MEDICINE