Beta cells in type 1 diabetes: mass and function; sleeping or dead?

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase

(2018) Beverley M. Shields et al.   DIABETES CARE

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes

(2018) Anna Neyman et al.   DIABETES OBESITY & METABOLISM

Pancreas Pathology During the Natural History of Type 1 Diabetes

(2018) Teresa Rodriguez-Calvo et al.   Current Diabetes Reports

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

(2018) Emily K. Sims et al.   DIABETES CARE

Assessment of β Cell Mass and Function by AIRmax and Intravenous Glucose in High-Risk Subjects for Type 1 Diabetes

(2017) Wei Hao et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis

(2017) Carol J Lam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA 1c , and Insulin Dose

(2016) Wei Hao et al.   DIABETES CARE

Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes

(2016) Georgina M. Williams et al.   DIABETOLOGIA

Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes

(2016) Abu Saleh Md Moin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

(2015) Marisa M. Fisher et al.   DIABETES

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

(2015) Lars Krogvold et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Pancreatic β-cell imaging in humans: fiction or option?

(2015) D. Laurent et al.   DIABETES OBESITY & METABOLISM

Diabetes mellitus—advances and challenges in human β-cell proliferation

(2015) Peng Wang et al.   Nature Reviews Endocrinology

Organ donor specimens: What can they tell us about type 1 diabetes?

(2015) Martha Campbell-Thompson   PEDIATRIC DIABETES

Structural similarities and differences between the human and the mouse pancreas

(2015) Jurij Dolenšek et al.   Islets

Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors

(2014) Richard A. Oram et al.   DIABETES CARE

Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes

(2014) Asa K. Davis et al.   DIABETES CARE

Insulin secretion measured by stimulated C-peptide in long-established Type 1 diabetes in the Diabetes Control and Complications Trial (DCCT)/ Epidemiology of Diabetes Interventions and Complications (EDIC) cohort: a pilot study

(2014) P. McGee et al.   DIABETIC MEDICINE

Immune modulation in humans: implications for type 1 diabetes mellitus

(2014) Bart O. Roep et al.   Nature Reviews Endocrinology

Effectiveness of Early Intensive Therapy on  -Cell Preservation in Type 1 Diabetes

(2013) B. Buckingham et al.   DIABETES CARE

Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

(2013) A. Barker et al.   DIABETES OBESITY & METABOLISM

The clinical utility of C-peptide measurement in the care of patients with diabetes

(2013) A. G. Jones et al.   DIABETIC MEDICINE

Why were we wrong for so long? The pancreas of type 1 diabetic patients commonly functions for decades

(2013) Denise L. Faustman   DIABETOLOGIA

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

(2013) Richard A. Oram et al.   DIABETOLOGIA

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings

(2013) Alberto Pugliese et al.   PEDIATRIC DIABETES

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

(2012) C. J. Greenbaum et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay

(2012) L. Wang et al.   DIABETES CARE

Plasma C-peptide concentration in women with Type 1 diabetes during early and late pregnancy

(2012) H. R. Murphy et al.   DIABETIC MEDICINE

Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study

(2012) D. Dabelea et al.   DIABETOLOGIA

Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass

(2012) C. Dirksen et al.   DIABETOLOGIA

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Detection of   cell death in diabetes using differentially methylated circulating DNA

(2011) E. M. Akirav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

The pancreas in human type 1 diabetes

(2010) Patrick A. Rowe et al.   Seminars in Immunopathology

Pregnancy-Induced Rise in Serum C-Peptide Concentrations in Women With Type 1 Diabetes

(2009) L. R. Nielsen et al.   DIABETES CARE

New Definition for the Partial Remission Period in Children and Adolescents With Type 1 Diabetes

(2009) H. B. Mortensen et al.   DIABETES CARE

 -Cell Mass and Type 1 Diabetes: Going, Going, Gone?

(2008) E. Akirav et al.   DIABETES

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of  -Cell Function in Therapeutic Trials in Type 1 Diabetes

(2008) C. J. Greenbaum et al.   DIABETES CARE

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Syndromes of Ketosis-Prone Diabetes Mellitus

(2008) Ashok Balasubramanyam et al.   ENDOCRINE REVIEWS

Interleukin-6 regulates pancreatic  -cell mass expansion

(2008) H. Ellingsgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA