The revitalization of antimicrobial peptides in the resistance era

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

Resistance Evolution Against Antimicrobial Peptides in Staphylococcus aureus Alters Pharmacodynamics Beyond the MIC

(2020) Baydaa El Shazely et al.   Frontiers in Microbiology

Antimicrobial peptides: Application informed by evolution

(2020) Brian P. Lazzaro et al.   SCIENCE

A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens

(2020) Meirong Song et al.   Nature Microbiology

Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

(2020) Yuri Takada et al.   Nature Communications

Combating bacterial resistance by combination of antibiotics with antimicrobial peptides

(2019) Dean E. Sheard et al.   PURE AND APPLIED CHEMISTRY

Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria

(2019) Jiajun Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of non-electrostatic forces in antimicrobial potency of a dengue-virus derived fusion peptide VG16KRKP: Mechanistic insight into the interfacial peptide-lipid interactions

(2019) Dipita Bhattacharyya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

(2019) Tao He et al.   Nature Microbiology

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

(2019) Biswajit Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli

(2019) Jian Sun et al.   Nature Microbiology

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

(2019) Rida Mourtada et al.   NATURE BIOTECHNOLOGY

Antagonizing Vancomycin Resistance in Enterococcus by Surface Localized Antimicrobial Display-Derived Peptides

(2019) Yuan Liu et al.   ACS Infectious Diseases

Antimicrobial Peptides as Anti-Infective Agents in Pre-Post-Antibiotic Era?

(2019) Tomislav Rončević et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

(2019) Anatol Luther et al.   NATURE

A new antibiotic selectively kills Gram-negative pathogens

(2019) Yu Imai et al.   NATURE

The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

(2019) Bo Ma et al.   Nature Communications

Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

(2019) Réka Spohn et al.   Nature Communications

Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

(2019) Dmitrii Y. Travin et al.   Nature Communications

The antimicrobial peptide ZY4 combats multidrug-resistantPseudomonas aeruginosaandAcinetobacter baumanniiinfection

(2019) James Mwangi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries

(2018) Ashley T. Tucker et al.   CELL

Murepavadin: a new antibiotic class in the pipeline

(2018) Ignacio Martin-Loeches et al.   Expert Review of Anti-Infective Therapy

Towards Understanding MCR-like Colistin Resistance

(2018) Jian Sun et al.   TRENDS IN MICROBIOLOGY

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

(2018) William F. Porto et al.   Nature Communications

Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

(2018) Viktória Lázár et al.   Nature Microbiology

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

(2018) Bradley M. Hover et al.   Nature Microbiology

OUP accepted manuscript

(2018)   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

High throughput screening of small immune peptides and antimicrobial peptides from the Fish-T1K database

(2018) Yunhai Yi et al.   GENOMICS

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

(2018) Jiajun Wang et al.   MEDICINAL RESEARCH REVIEWS

Discovery of Linear Low-Cationic Peptides to Target Methicillin-Resistant Staphylococcus aureus in Vivo

(2018) Yuan Liu et al.   ACS Infectious Diseases

The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance

(2017) Jason Munguia et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A high-throughput expression screening platform to optimize the production of antimicrobial peptides

(2017) Christine Schreiber et al.   Microbial Cell Factories

Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae

(2017) Natasha Weston et al.   RESEARCH IN MICROBIOLOGY

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

(2017) Teruaki Nakatsuji et al.   Science Translational Medicine

Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

(2017) Junying Ma et al.   Nature Communications

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

(2017) Xiaozhe Wu et al.   Drug Design Development and Therapy

Membrane-Active Amphipathic Peptide WRL3 with in Vitro Antibiofilm Capability and in Vivo Efficacy in Treating Methicillin-Resistant Staphylococcus aureus Burn Wound Infections

(2017) Zhi Ma et al.   ACS Infectious Diseases

Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound

(2017) Ezra M.C. Chung et al.   npj Biofilms and Microbiomes

How Membrane-Active Peptides Get into Lipid Membranes

(2016) Marc-Antoine Sani et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antifungal peptides: To be or not to be membrane active

(2016) Marina Rautenbach et al.   BIOCHIMIE

Computer-aided design, structural dynamics analysis, and in vitro susceptibility test of antibacterial peptides incorporating unnatural amino acids against microbial infections

(2016) Yan Wang et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Short Antimicrobial Peptides and Peptide Scaffolds as Promising Antibacterial Agents

(2016) Ronald Domalaon et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)

(2016) Paulina Kosikowska et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

(2016) John Chu et al.   Nature Chemical Biology

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure

(2015) Tzong-Hsien Lee et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Lipopolysaccharide Phosphorylation by the WaaY Kinase Affects the Susceptibility ofEscherichia colito the Human Antimicrobial Peptide LL-37

(2015) Karol Bociek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Tackling antibiotic resistance: the environmental framework

(2015) Thomas U. Berendonk et al.   NATURE REVIEWS MICROBIOLOGY

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Helical antimicrobial polypeptides with radial amphiphilicity

(2015) Menghua Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting DnaN for tuberculosis therapy using novel griselimycins

(2015) A. Kling et al.   SCIENCE

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

(2014) Wenyi Li et al.   AMINO ACIDS

Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane

(2014) Hiroshi Hamamoto et al.   Nature Chemical Biology

Small cationic antimicrobial peptides delocalize peripheral membrane proteins

(2014) M. Wenzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of anticancer action and cell selectivity of short α-helical peptides

(2013) Cuixia Chen et al.   BIOMATERIALS

Lantibiotics: Promising candidates for future applications in health care

(2013) Jasmin Dischinger et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

LL-37 in periodontal health and disease and its susceptibility to degradation by proteinases present in gingival crevicular fluid

(2013) Maelíosa T. C. McCrudden et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Antimicrobial peptides stage a comeback

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

(2013) Ashley L Hilchie et al.   Nature Chemical Biology

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic

(2013) Danielle M. McGrath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery

(2012) Andrew G. Jamieson et al.   Chemical Biology & Drug Design

Recent development of small antimicrobial peptidomimetics

(2012) Youhong Niu et al.   Future Medicinal Chemistry

Ab Initio Design of Potent Anti-MRSA Peptides Based on Database Filtering Technology

(2012) Biswajit Mishra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tuning the Activity of a Short Arg-Trp Antimicrobial Peptide by Lipidation of a C- or N-Terminal Lysine Side-Chain

(2012) H. Bauke Albada et al.   ACS Medicinal Chemistry Letters

Antimicrobial peptides: key components of the innate immune system

(2011) Mukesh Pasupuleti et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study

(2011) Timothy R Walsh et al.   LANCET INFECTIOUS DISEASES

Cathelicidin-BF, a Snake Cathelicidin-Derived Antimicrobial Peptide, Could Be an Excellent Therapeutic Agent for Acne Vulgaris

(2011) Yipeng Wang et al.   PLoS One

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

Identification of Novel Human Immunodeficiency Virus Type 1-Inhibitory Peptides Based on the Antimicrobial Peptide Database

(2010) G. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity

(2010) Daisuke Takahashi et al.   BIOCHIMIE

Computational approaches to therapeutic peptide discovery

(2010) Yossef Kliger   BIOPOLYMERS

Optimization of Antibacterial Peptides by Genetic Algorithms and Cheminformatics

(2010) Christopher D. Fjell et al.   Chemical Biology & Drug Design

Antimicrobial β-Peptides and α-Peptoids

(2010) Troels Godballe et al.   Chemical Biology & Drug Design

Concepts and Applications of “Natural Computing” Techniques in De Novo Drug and Peptide Design

(2010) Jan A. Hiss et al.   CURRENT PHARMACEUTICAL DESIGN

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

(2010) G. H. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Alpha-helical cationic antimicrobial peptides: relationships of structure and function

(2010) Yibing Huang et al.   Protein & Cell

Gaussian process: an alternative approach for QSAM modeling of peptides

(2009) Peng Zhou et al.   AMINO ACIDS

Multifunctional host defense peptides: antiparasitic activities

(2009) Amram Mor   FEBS Journal

SoxRS-Mediated Lipopolysaccharide Modification Enhances Resistance against Multiple Drugs in Escherichia coli

(2009) J.-H. Lee et al.   JOURNAL OF BACTERIOLOGY

Identification of Novel Antibacterial Peptides by Chemoinformatics and Machine Learning†

(2009) Christopher D. Fjell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

(2009) Manuel N. Melo et al.   NATURE REVIEWS MICROBIOLOGY

Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs

(2008) Artem Cherkasov et al.   ACS Chemical Biology

Interaction of LL-37 with Model Membrane Systems of Different Complexity: Influence of the Lipid Matrix

(2008) E. Sevcsik et al.   BIOPHYSICAL JOURNAL

Synthetic Antimicrobial Peptidomimetics with Therapeutic Potential

(2008) Bengt Erik Haug et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Basis for Proline- and Arginine-Rich Peptide Inhibition of Proteasome

(2008) Asokan Anbanandam et al.   JOURNAL OF MOLECULAR BIOLOGY

APD2: the updated antimicrobial peptide database and its application in peptide design

(2008) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Identification of a novel storage glycine-rich peptide from guava (Psidium guajava) seeds with activity against Gram-negative bacteria

(2008) Patricia B. Pelegrini et al.   PEPTIDES

Studies on anticancer activities of antimicrobial peptides

(2007) David W. Hoskin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES