Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

(2017) Bai-Yu Lee et al.   Nature Communications

TB deaths rank alongside HIV deaths as top infectious killer

(2016) Philippe Glaziou et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Deciphering the Biosynthetic Origin of l-allo-Isoleucine

(2015) Qinglian Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594

(2015) Yongxiang Song et al.   Marine Drugs

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase

(2014) Angelica O. Zabala et al.   ACS Chemical Biology

Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria

(2014) Yongxiang Song et al.   JOURNAL OF NATURAL PRODUCTS

Adenylation and S-Methylation of Cysteine by the Bifunctional Enzyme TioN in Thiocoraline Biosynthesis

(2014) Ahmad H. Al-Mestarihi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

(2014) Alimuddin I Zumla et al.   LANCET INFECTIOUS DISEASES

LovG: The Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover in Lovastatin Biosynthesis

(2013) Wei Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects

(2012) Rafael Radi   ACCOUNTS OF CHEMICAL RESEARCH

Abyssomicins from the South China Sea Deep-Sea SedimentVerrucosisporasp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs

(2012) Qian Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652

(2012) Xiao Zhou et al.   JOURNAL OF NATURAL PRODUCTS

India reports cases of totally drug-resistant tuberculosis

(2012) Samuel Loewenberg   LANCET

Unexpected high levels of multidrug-resistant tuberculosis present new challenges for tuberculosis control

(2012) Sven Hoffner   LANCET

Diversity of P450 enzymes in the biosynthesis of natural products

(2012) Larissa M. Podust et al.   NATURAL PRODUCT REPORTS

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

(2012) Sarah M Barry et al.   Nature Chemical Biology

Autoluminescent Mycobacterium tuberculosis for Rapid, Real-Time, Non-Invasive Assessment of Drug and Vaccine Efficacy

(2012) Tianyu Zhang et al.   PLoS One

Biosynthesis of Himastatin: Assembly Line and Characterization of Three Cytochrome P450 Enzymes Involved in the Post-tailoring Oxidative Steps

(2011) Junying Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation

(2011) Shunji Takahashi et al.   Nature Chemical Biology

Mutagenesis of a Modular Polyketide Synthase Enoylreductase Domain Reveals Insights into Catalysis and Stereospecificity

(2010) David H. Kwan et al.   ACS Chemical Biology

Regioselective Domino Metathesis of Unsymmetrical 7-Oxanorbornenes with Electron-Rich Vinyl Acetate toward Biologically Active Glutamate Analogues

(2009) Masato Oikawa et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

OLEX2: a complete structure solution, refinement and analysis program

(2009) Oleg V. Dolomanov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Enzymatic Tailoring of Ornithine in the Biosynthesis of theRhizobiumCyclic Trihydroxamate Siderophore Vicibactin

(2009) John R. Heemstra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein tyrosine nitration—Functional alteration or just a biomarker?

(2008) José M. Souza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biosynthesis and Structures of Cyclomarins and Cyclomarazines, Prenylated Cyclic Peptides of Marine Actinobacterial Origin

(2008) Andrew W. Schultz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Medium-Chain Dehydrogenase/Reductase Engineering Database: A systematic analysis of a diverse protein family to understand sequence-structure-function relationship

(2008) Michael Knoll et al.   PROTEIN SCIENCE

The Crystal Structure of a Mammalian Fatty Acid Synthase

(2008) T. Maier et al.   SCIENCE

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase

(2007) Hrvoje Petković et al.   ORGANIC & BIOMOLECULAR CHEMISTRY