Antimicrobial host defence peptides: functions and clinical potential
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Antimicrobial host defence peptides: functions and clinical potential
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-02-27
DOI
10.1038/s41573-019-0058-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Peptide Design Principles for Antimicrobial Applications
- (2019) Marcelo D.T. Torres et al. JOURNAL OF MOLECULAR BIOLOGY
- De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii
- (2019) Colin T. Mant et al. JOURNAL OF MEDICINAL CHEMISTRY
- Improved Methods for Assessing Therapeutic Potential of Antifungal Agents Against Dermatophytes and their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate
- (2019) Derry K Mercer et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Docking on Lipid II - a Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides
- (2019) Fabian Grein et al. JOURNAL OF MOLECULAR BIOLOGY
- Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection
- (2019) Shasha Jiang et al. mBio
- Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa
- (2019) Brian J. McHugh et al. PLoS Pathogens
- Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach
- (2019) Mark Austin Hanson et al. eLife
- Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy
- (2019) Emily Gwyer Findlay et al. OncoImmunology
- In vivo exposure of insect AMP resistant Staphylococcus aureus to an insect immune system
- (2019) Baydaa El Shazely et al. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm
- (2019) Kathryn Wynne Woodburn et al. Frontiers in Microbiology
- Facile and efficient encapsulation of antimicrobial peptides via crosslinked DNA nanostructures and their application in wound therapy
- (2019) Sybil Obuobi et al. JOURNAL OF CONTROLLED RELEASE
- Epidermal hepcidin is required for neutrophil response to bacterial infection
- (2019) Mariangela Malerba et al. JOURNAL OF CLINICAL INVESTIGATION
- Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
- (2018) Ashley T. Tucker et al. CELL
- Antifungal drug resistance: evolution, mechanisms and impact
- (2018) Nicole M Revie et al. CURRENT OPINION IN MICROBIOLOGY
- The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance
- (2018) Teizo Yoshimura et al. JOURNAL OF IMMUNOLOGY
- A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
- (2018) Alicia Wong et al. JOURNAL OF IMMUNOLOGY
- The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
- (2018) Anna de Breij et al. Science Translational Medicine
- The evolution, function and mechanisms of action for plant defensins
- (2018) Kathy Parisi et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness
- (2018) Hadeesha Piyadasa et al. THORAX
- Yeast-Based Synthetic Biology Platform for Antimicrobial Peptide Production
- (2018) Jicong Cao et al. ACS Synthetic Biology
- Cathelicidin-Derived Antimicrobial Peptides Inhibit Zika Virus Through Direct Inactivation and Interferon Pathway
- (2018) Miao He et al. Frontiers in Immunology
- LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells
- (2018) David C. Brice et al. ANTIVIRAL RESEARCH
- Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase
- (2018) Mahadevappa Hemshekhar et al. Frontiers in Immunology
- Clarithromycin Enhances the Antibacterial Activity and Wound Healing Capacity in Type 2 Diabetes Mellitus by Increasing LL-37 Load on Neutrophil Extracellular Traps
- (2018) Athanasios Arampatzioglou et al. Frontiers in Immunology
- Recent achievements and perspectives for large-scale recombinant production of antimicrobial peptides
- (2018) David Wibowo et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Development of Silicone Hydrogel Antimicrobial Contact Lenses with Mel4 Peptide Coating
- (2018) Debarun Dutta et al. OPTOMETRY AND VISION SCIENCE
- A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis
- (2018) Erik Tenland et al. TUBERCULOSIS
- Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota
- (2018) Bálint Kintses et al. Nature Microbiology
- An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses
- (2017) David J. Holthausen et al. IMMUNITY
- Cathelicidins InhibitEscherichia coli–Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner
- (2017) Maarten Coorens et al. JOURNAL OF IMMUNOLOGY
- Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model
- (2017) Bing Catherine Wu et al. JOURNAL OF IMMUNOLOGY
- IL-1β–Induced Protection of Keratinocytes against Staphylococcus aureus -Secreted Proteases Is Mediated by Human β-Defensin 2
- (2017) Bingjie Wang et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture
- (2017) Patricia Severino et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition: Application to the detection of “cryptic” antimicrobial peptides
- (2017) Katia Pane et al. JOURNAL OF THEORETICAL BIOLOGY
- The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
- (2017) Jelena Pantic et al. MOLECULES
- Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice
- (2017) Kai Schulze et al. Nanomedicine-Nanotechnology Biology and Medicine
- Proline-rich antimicrobial peptides targeting protein synthesis
- (2017) Michael Graf et al. NATURAL PRODUCT REPORTS
- Cathelicidins display conserved direct antiviral activity towards rhinovirus
- (2017) Filipa Henderson Sousa et al. PEPTIDES
- Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
- (2017) Teruaki Nakatsuji et al. Science Translational Medicine
- Induction of a balanced IgG1/IgG2 immune response to an experimental challenge with Mycoplasma bovis antigens following a vaccine composed of Emulsigen™, IDR peptide1002, and poly I:C
- (2017) Tracy Prysliak et al. VACCINE
- Human Beta Defensin 2 Selectively Inhibits HIV-1 in Highly Permissive CCR6+CD4+ T Cells
- (2017) Mark Lafferty et al. Viruses-Basel
- α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome
- (2017) Mayim E. Wiens et al. mBio
- Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism
- (2017) Lorenzo P. Menzel et al. Scientific Reports
- Defensins in Viral Infection and Pathogenesis
- (2017) Mayumi K. Holly et al. Annual Review of Virology
- Antimicrobial Peptides As Biologic and Immunotherapeutic Agents against Cancer: A Comprehensive Overview
- (2017) Raheleh Roudi et al. Frontiers in Immunology
- Antimicrobial Peptides in Biomedical Device Manufacturing
- (2017) Martijn Riool et al. Frontiers in Chemistry
- Interaction of Antibiotics with Innate Host Defense Factors against Salmonella enterica Serotype Newport
- (2017) George Sakoulas et al. mSphere
- Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response
- (2017) Viktoria A. F. Schneider et al. mSphere
- Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection
- (2017) Kelli C. Wuerth et al. PLoS One
- Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis
- (2017) Maarten Coorens et al. Scientific Reports
- Synthetic antibiofilm peptides
- (2016) César de la Fuente-Núñez et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity
- (2016) Li-Hua Peng et al. BIOMATERIALS
- Immune responses to Mycoplasma bovis proteins formulated with different adjuvants
- (2016) Tracy Prysliak et al. CANADIAN JOURNAL OF MICROBIOLOGY
- Convergent evolution of defensin sequence, structure and function
- (2016) Thomas M. A. Shafee et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Mimics of Host Defense Proteins; Strategies for Translation to Therapeutic Applications
- (2016) Richard W. Scott et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Antimicrobial Peptides as a Strategy to Combat Fungal Biofilms
- (2016) Nicolas Delattin et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Antimicrobial Peptides Under Clinical Trials
- (2016) Katarzyna E. Greber et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Mechanisms and consequences of bacterial resistance to antimicrobial peptides
- (2016) D.I. Andersson et al. DRUG RESISTANCE UPDATES
- Effects of vancomycin versus nafcillin in enhancing killing of methicillin-susceptible Staphylococcus aureus causing bacteremia by human cathelicidin LL-37
- (2016) J. Le et al. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- Histones as mediators of host defense, inflammation and thrombosis
- (2016) Marloes Hoeksema et al. Future Microbiology
- LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages
- (2016) Alexander Stephan et al. IMMUNOLOGY
- Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDRStenotrophomonas maltophilia
- (2016) Monika Kumaraswamy et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A novel approach for emerging and antibiotic resistant infections: Innate defense regulators as an agnostic therapy
- (2016) John R. North et al. JOURNAL OF BIOTECHNOLOGY
- Cutting Edge: LL-37–Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer’s Patch Germinal Centers
- (2016) Sae-Hae Kim et al. JOURNAL OF IMMUNOLOGY
- Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans
- (2016) Silke M. Currie et al. JOURNAL OF IMMUNOLOGY
- Human fungal pathogens: Why should we learn?
- (2016) Jeong-Yoon Kim JOURNAL OF MICROBIOLOGY
- The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective
- (2016) Sharon M. Donovan JOURNAL OF PEDIATRICS
- The Defensins Consist of Two Independent, Convergent Protein Superfamilies
- (2016) Thomas M. A. Shafee et al. MOLECULAR BIOLOGY AND EVOLUTION
- Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice
- (2016) YUAN-YUAN DENG et al. Molecular Medicine Reports
- Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine
- (2016) Natascia Bruni et al. MOLECULES
- Antimicrobial peptides in marine invertebrate health and disease: Table 1.
- (2016) Delphine Destoumieux-Garzón et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Bacterial strategies of resistance to antimicrobial peptides
- (2016) Hwang-Soo Joo et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Diversity, evolution and medical applications of insect antimicrobial peptides
- (2016) Eleftherios Mylonakis et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides
- (2016) Albert van Dijk et al. PLoS One
- Inhaled corticosteroids and the increased risk of pneumonia: what’s new? A 2015 updated review
- (2016) Hernan Iannella et al. Therapeutic Advances in Respiratory Disease
- Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli
- (2016) Tryntsje Cuperus et al. Scientific Reports
- Imaging the antimicrobial mechanism(s) of cathelicidin-2
- (2016) Viktoria A. F. Schneider et al. Scientific Reports
- Bacterial resistance to antimicrobial peptides
- (2015) Hans-Georg Sahl et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Review paper Cathelicidin impact on inflammatory cells
- (2015) Justyna Agier et al. Central European Journal of Immunology
- Azole Resistance inAspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?
- (2015) Paul E. Verweij et al. CLINICAL INFECTIOUS DISEASES
- Defensins: “Simple” antimicrobial peptides or broad-spectrum molecules?
- (2015) Meggy Suarez-Carmona et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Peptide therapeutics: Targeting the undruggable space
- (2015) Natia Tsomaia EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37
- (2015) Aline Schögler et al. EUROPEAN RESPIRATORY JOURNAL
- LL37 inhibits the inflammatory endothelial response induced by viral or endogenous DNA
- (2015) Monika Merkle et al. JOURNAL OF AUTOIMMUNITY
- Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation
- (2015) Maarten Coorens et al. JOURNAL OF IMMUNOLOGY
- Synthetic innate defense regulator peptide combination using CpG ODN as a novel adjuvant induces long-lasting and balanced immune responses
- (2015) CHAO-HENG YU et al. Molecular Medicine Reports
- APD3: the antimicrobial peptide database as a tool for research and education
- (2015) Guangshun Wang et al. NUCLEIC ACIDS RESEARCH
- High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides
- (2015) Evan F. Haney et al. PEPTIDES
- Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation
- (2015) T. W. Cullen et al. SCIENCE
- Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid
- (2015) Fiona Semple et al. PLoS Genetics
- Vitamin D 3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial
- (2015) Adrian R Martineau et al. Lancet Respiratory Medicine
- Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens
- (2015) Leo Lin et al. EBioMedicine
- Fungicidal Mechanisms of Cathelicidins LL-37 and CATH-2 Revealed by Live-Cell Imaging
- (2014) Soledad R. Ordonez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- How Does It Kill?: Understanding the Candidacidal Mechanism of Salivary Histatin 5
- (2014) Sumant Puri et al. EUKARYOTIC CELL
- Interplay between Candida albicans and the Antimicrobial Peptide Armory
- (2014) Marc Swidergall et al. EUKARYOTIC CELL
- Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation
- (2014) Ka-Yee G. Choi et al. IMMUNOLOGY
- Bitter and sweet taste receptors regulate human upper respiratory innate immunity
- (2014) Robert J. Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis
- (2014) J. Koziel et al. JOURNAL OF IMMUNOLOGY
- Alarmin Function of Cathelicidin Antimicrobial Peptide LL37 through IL-36γ Induction in Human Epidermal Keratinocytes
- (2014) Na Li et al. JOURNAL OF IMMUNOLOGY
- LL-37 modulates human neutrophil responses to influenza A virus
- (2014) Shweta Tripathi et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections
- (2014) Sarah C. Mansour et al. JOURNAL OF PEPTIDE SCIENCE
- Antifungal Plant Defensins: Mechanisms of Action and Production
- (2014) Kim Vriens et al. MOLECULES
- Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo
- (2014) Paula E. Beaumont et al. PLoS One
- PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial
- (2014) Monica E. Wiig et al. PLoS One
- Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trial
- (2014) Alvar Grönberg et al. WOUND REPAIR AND REGENERATION
- Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus
- (2014) Wanyi Li et al. Viruses-Basel
- Delineation of Interfaces on Human Alpha-Defensins Critical for Human Adenovirus and Human Papillomavirus Inhibition
- (2014) Victoria R. Tenge et al. PLoS Pathogens
- Antimicrobial Peptide LL-37 and IDR-1 Ameliorate MRSA Pneumonia in Vivo
- (2013) Man Hou et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs
- (2013) Sonia Melino et al. FEBS Journal
- Gene Therapy with Beta-Defensin 2 Induces Antitumor Immunity and Enhances Local Antitumor Effects
- (2013) Dan Li et al. HUMAN GENE THERAPY
- -Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN- Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation
- (2013) P. Tewary et al. JOURNAL OF IMMUNOLOGY
- The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions
- (2013) François Niyonsaba et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Human cathelicidin LL-37-derived peptide IG-19 confers protection in a murine model of collagen-induced arthritis
- (2013) Leola N.Y. Chow et al. MOLECULAR IMMUNOLOGY
- Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models
- (2013) Bruno Rivas-Santiago et al. PLoS One
- Chicken Cathelicidins Display Antimicrobial Activity against Multiresistant Bacteria without Inducing Strong Resistance
- (2013) Edwin J. A. Veldhuizen et al. PLoS One
- The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus
- (2013) Silke M. Currie et al. PLoS One
- Oral intake of phenylbutyrate with or without vitamin D3upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis
- (2013) Akhirunnesa Mily et al. BMC Pulmonary Medicine
- Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease
- (2012) Patrick Mallia et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Topical vitamin D3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions
- (2012) E. Sato-Deguchi et al. BRITISH JOURNAL OF DERMATOLOGY
- Intrarectal administration of mCRAMP-encoding plasmid reverses exacerbated colitis in Cnlp−/− mice
- (2012) E K K Tai et al. GENE THERAPY
- The antimicrobial peptide cathelicidin modulatesClostridium difficile-associated colitis and toxin A-mediated enteritis in mice
- (2012) Tressia C Hing et al. GUT
- θ-Defensins: Cyclic Peptides with Endless Potential: FIGURE 1.
- (2012) Robert I. Lehrer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Multifaceted Mechanisms of HIV-1 Entry Inhibition by Human α-Defensin
- (2012) Lusine H. Demirkhanyan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis
- (2012) Clover Ching Man Wong et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins
- (2012) S. Tripathi et al. JOURNAL OF GENERAL VIROLOGY
- Hapivirins and Diprovirins: Novel -Defensin Analogs with Potent Activity against Influenza A Virus
- (2012) M. Doss et al. JOURNAL OF IMMUNOLOGY
- Cathelicidin-Related Antimicrobial Peptide Is Required for Effective Lung Mucosal Immunity in Gram-Negative Bacterial Pneumonia
- (2012) M. A. Kovach et al. JOURNAL OF IMMUNOLOGY
- Synthetic Immunomodulatory Peptide IDR-1002 Enhances Monocyte Migration and Adhesion on Fibronectin
- (2012) Laurence Madera et al. Journal of Innate Immunity
- ß-Defensins: Multifunctional Modulators of Infection, Inflammation and More?
- (2012) Fiona Semple et al. Journal of Innate Immunity
- Enhancement of Antiviral Activity of Human Alpha-Defensin 5 against Herpes Simplex Virus 2 by Arginine Mutagenesis at Adaptive Evolution Sites
- (2012) A. Wang et al. JOURNAL OF VIROLOGY
- Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
- (2012) Alejandro A. Pezzulo et al. NATURE
- Effective Adjunctive Therapy by an Innate Defense Regulatory Peptide in a Preclinical Model of Severe Malaria
- (2012) A. H. Achtman et al. Science Translational Medicine
- Serious infections in a population-based cohort of 86,039 seniors with rheumatoid arthritis
- (2012) Jessica Widdifield et al. ARTHRITIS CARE & RESEARCH
- Multiple Immune-Modulatory Functions Of Cathelicidin Host Defense Peptides
- (2012) Ka-Yee (Grace) Choi et al. Frontiers in Immunology
- Peptidylarginine Deiminases Present in the Airways during Tobacco Smoking and Inflammation Can Citrullinate the Host Defense Peptide LL-37, Resulting in Altered Activities
- (2011) Ola Kilsgård et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF
- (2011) Fiona Semple et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Toll-like receptor 1/2 agonists Pam3CSK4 and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes
- (2011) Nicholas T. Funderburg et al. IMMUNOLOGY
- CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo
- (2011) Ding Cao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Modulation of human β-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity
- (2011) Lisa K. Ryan et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
- (2011) Charles L. Bevins et al. NATURE REVIEWS MICROBIOLOGY
- Effects of cathelicidin and its fragments on three key enzymes of HIV-1
- (2011) Jack Ho Wong et al. PEPTIDES
- Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37
- (2011) Peter G. Barlow et al. PLoS One
- LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs
- (2011) Yvonne Lai et al. PLoS One
- Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37
- (2011) K. A. Sochacki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus
- (2011) R. Lande et al. Science Translational Medicine
- Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis
- (2011) Srinivas Garlapati et al. VACCINE
- The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium
- (2010) Peter G. Barlow et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Recombinant mouse beta-defensin 2 inhibits infection by influenza A virus by blocking its entry
- (2010) Tianxiang Gong et al. ARCHIVES OF VIROLOGY
- The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils
- (2010) Sadek M. Alalwani et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Human β-defensin 3 has immunosuppressive activityin vitroandin vivo
- (2010) Fiona Semple et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II
- (2010) Erik de Leeuw et al. FEBS LETTERS
- Host defense peptides and their antimicrobial-immunomodulatory duality
- (2010) Lars Steinstraesser et al. IMMUNOBIOLOGY
- Human -Defensin 3 Inhibits Cell Wall Biosynthesis in Staphylococci
- (2010) V. Sass et al. INFECTION AND IMMUNITY
- Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications
- (2010) William K.K. Wu et al. INTERNATIONAL JOURNAL OF CANCER
- Flagellin Stimulates Protective Lung Mucosal Immunity: Role of Cathelicidin-Related Antimicrobial Peptide
- (2010) F.-s. Yu et al. JOURNAL OF IMMUNOLOGY
- Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment
- (2010) Anastasia Nijnik et al. JOURNAL OF IMMUNOLOGY
- Direct Evidence from Single-Cell Analysis that Human -Defensins Block Adenovirus Uncoating To Neutralize Infection
- (2010) E. K. Nguyen et al. JOURNAL OF VIROLOGY
- A carpet-based mechanism for direct antimicrobial peptide activity against vaccinia virus membranes
- (2010) R.E. Dean et al. PEPTIDES
- Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization
- (2010) Jason G. Smith et al. PLoS Pathogens
- Bombinins, antimicrobial peptides from Bombina species
- (2009) Maurizio Simmaco et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses
- (2009) E. Margo Molhoek et al. BIOLOGICAL CHEMISTRY
- Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils
- (2009) Zhifang Zhang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli
- (2009) Niall C.J. Filewod et al. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
- Sequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide
- (2009) Hong Bing Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
- (2009) Dipyaman Ganguly et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Interactions of -, -, and -Defensins with Influenza A Virus and Surfactant Protein D
- (2009) M. Doss et al. JOURNAL OF IMMUNOLOGY
- Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of -Defensins
- (2009) K. Miles et al. JOURNAL OF IMMUNOLOGY
- Multivalent Binding of Carbohydrates by the Human -Defensin, HD5
- (2009) R. I. Lehrer et al. JOURNAL OF IMMUNOLOGY
- Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes
- (2009) N. Mookherjee et al. JOURNAL OF IMMUNOLOGY
- LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline
- (2009) G. Bergsson et al. JOURNAL OF IMMUNOLOGY
- Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages
- (2009) Hsin-Ni Li et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease
- (2009) C. L. Wohlford-Lenane et al. JOURNAL OF VIROLOGY
- The Human Host Defense Peptide LL-37 Induces Apoptosis in a Calpain- and Apoptosis-Inducing Factor-Dependent Manner Involving Bax Activity
- (2009) J. S. Mader et al. MOLECULAR CANCER RESEARCH
- Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS
- (2009) Albert van Dijk et al. MOLECULAR IMMUNOLOGY
- Enteric defensins are essential regulators of intestinal microbial ecology
- (2009) Nita H Salzman et al. NATURE IMMUNOLOGY
- Vitamin D Analogs Differentially Control Antimicrobial Peptide/“Alarmin”Expression in Psoriasis
- (2009) Mark Peric et al. PLoS One
- A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity
- (2009) Jason Kindrachuk et al. VACCINE
- Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans
- (2009) Constantin F. Urban et al. PLoS Pathogens
- Mechanism of Adenovirus Neutralization by Human α-Defensins
- (2008) Jason G. Smith et al. Cell Host & Microbe
- Topical versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double‐Blinded, Multicenter Trial of Pexiganan Cream
- (2008) Benjamin A. Lipsky et al. CLINICAL INFECTIOUS DISEASES
- Role of Human β-Defensin-2 during Tumor Necrosis Factor-α/NF-κB-mediated Innate Antiviral Response against Human Respiratory Syncytial Virus
- (2008) Srikanth Kota et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin
- (2008) Zhifang Zhang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Antimicrobial human beta-defensin-2 stimulates migration, proliferation and tube formation of human umbilical vein endothelial cells
- (2008) Adone Baroni et al. PEPTIDES
- In vitro and In vivo Wound Healing-Promoting Activities of Human Cathelicidin LL-37
- (2007) Marta Carretero et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started