Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

 -Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-  Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation

(2013) P. Tewary et al.   JOURNAL OF IMMUNOLOGY

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions

(2013) François Niyonsaba et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models

(2013) Bruno Rivas-Santiago et al.   PLoS One

Synthetic Cationic Peptide IDR-1018 Modulates Human Macrophage Differentiation

(2013) Olga M. Pena et al.   PLoS One

Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies

(2013) Monika Polewicz et al.   VACCINE

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

(2012) Dieter Vandamme et al.   CELLULAR IMMUNOLOGY

Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections

(2012) Nicole J. Afacan et al.   CURRENT PHARMACEUTICAL DESIGN

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

(2012) M. L. Mayer et al.   JOURNAL OF IMMUNOLOGY

Synthetic Immunomodulatory Peptide IDR-1002 Enhances Monocyte Migration and Adhesion on Fibronectin

(2012) Laurence Madera et al.   Journal of Innate Immunity

Modulating immunity as a therapy for bacterial infections

(2012) Robert E. W. Hancock et al.   NATURE REVIEWS MICROBIOLOGY

Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection

(2012) Lars Steinstraesser et al.   PLoS One

Effective Adjunctive Therapy by an Innate Defense Regulatory Peptide in a Preclinical Model of Severe Malaria

(2012) A. H. Achtman et al.   Science Translational Medicine

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles

(2012) S. Garlapati et al.   VACCINE

Nonviral human beta defensin-3 expression in a bioengineered human skin tissue: A therapeutic alternative for infected wounds

(2012) Angela L. Gibson et al.   WOUND REPAIR AND REGENERATION

New insights into cathelicidin modulation of adaptive immunity

(2011) Kelli Wuerth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mas-related Gene X2 (MrgX2) Is a Novel G Protein-coupled Receptor for the Antimicrobial Peptide LL-37 in Human Mast Cells

(2011) Hariharan Subramanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

(2011) K. L. Brown et al.   JOURNAL OF IMMUNOLOGY

Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor

(2011) A Girnita et al.   ONCOGENE

Wound healing activity of the human antimicrobial peptide LL37

(2011) Reinaldo Ramos et al.   PEPTIDES

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis

(2011) Srinivas Garlapati et al.   VACCINE

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations

(2011) Aleksandra Gracia et al.   VACCINE

Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection

(2011) Tyler H.T. Brown et al.   VACCINE

Immunomodulators as adjuvants for vaccines and antimicrobial therapy

(2010) Erin F. Nicholls et al.   Annals of the New York Academy of Sciences

Structural Studies of a Peptide with Immune Modulating and Direct Antimicrobial Activity

(2010) Michal Wieczorek et al.   CHEMISTRY & BIOLOGY

The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

(2010) Sadek M. Alalwani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes

(2010) Jamie S. Mader et al.   EXPERIMENTAL CELL RESEARCH

Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds

(2010) Gimano D. Amatngalim et al.   INFLAMMATION

Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment

(2010) Anastasia Nijnik et al.   JOURNAL OF IMMUNOLOGY

LL-37 Directs Macrophage Differentiation toward Macrophages with a Proinflammatory Signature

(2010) A. M. van der Does et al.   JOURNAL OF IMMUNOLOGY

Human  -Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

(2010) J. Rohrl et al.   JOURNAL OF IMMUNOLOGY

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils

(2009) Zhifang Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide

(2009) Hong Bing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LL-37 Promotes Rapid Sensing of CpG Oligodeoxynucleotides by B Lymphocytes and Plasmacytoid Dendritic Cells

(2009) P. Hurtado et al.   JOURNAL OF IMMUNOLOGY

The Cathelicidin LL-37 Activates Human Mast Cells and Is Degraded by Mast Cell Tryptase: Counter-Regulation by CXCL4

(2009) F. Schiemann et al.   JOURNAL OF IMMUNOLOGY

Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes

(2009) N. Mookherjee et al.   JOURNAL OF IMMUNOLOGY

Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-  on APCs

(2009) A. Nijnik et al.   JOURNAL OF IMMUNOLOGY

Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91

(2009) Pietro Presicce et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells

(2009) Neeloffer Mookherjee et al.   Molecular BioSystems

Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity

(2009) Jan-Michel Otte et al.   REGULATORY PEPTIDES

Enabling a systems biology approach to immunology: focus on innate immunity

(2009) Jennifer L. Gardy et al.   TRENDS IN IMMUNOLOGY

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

(2009) Jason Kindrachuk et al.   VACCINE

Endogenous antimicrobial peptide LL-37 induces human vasodilatation † †A preliminary account of these results has been presented to the 29th Congress of the Scandinavian Society of Anaesthesiology and Intensive Care, Gothenburg, September 5–8, 2007.

(2008) I. Berkestedt et al.   BRITISH JOURNAL OF ANAESTHESIA

Host Defence Peptide LL-37 Induces IL-6 Expression in Human Bronchial Epithelial Cells by Activation of the NF-κB Signaling Pathway

(2008) Jelena Pistolic et al.   Journal of Innate Immunity

Murine  -defensin 2 promotes TLR-4/MyD88-mediated and NF- B-dependent atypical death of APCs via activation of TNFR2

(2008) A. Biragyn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Unknown

(2008) Lars Steinstraesser et al.   MOLECULAR MEDICINE