Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury

Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity

(2020) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration

(2020) Yara A. Samra et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Purine signaling regulating HSCs inflammatory cytokines secretion, activation, and proliferation plays a critical role in alcoholic liver disease

(2020) Liang Shan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy

(2020) Jiaqi Zhang et al.   Frontiers in Pharmacology

Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome

(2020) Dong Liu et al.   DRUG DEVELOPMENT RESEARCH

Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice

(2020) Zhi-Dan Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway

(2020) Ke Yang et al.   CYTOKINE

The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy

(2020) Hongming Lv et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation

(2020) Xue Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation

(2020) Hongming Lv et al.   PHYTOMEDICINE

Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo

(2020) Hui Chen et al.   Drug Design Development and Therapy

Wolfberry‐Derived Zeaxanthin Dipalmitate Attenuates Ethanol‐Induced Hepatic Damage

(2019) Hao Gao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A

(2019) Hongming Lv et al.   Cell Death & Disease

Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation

(2019) Ying He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress

(2019) Zheng Lyu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

(2019) Yuting Jin et al.   Cellular & Molecular Immunology

The role of inflammasome activation in Triptolide-induced acute liver toxicity

(2019) Ziqiao Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis

(2019) Hongming Lv et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway

(2019) Xiao Liu et al.   Frontiers in Pharmacology

Acetaminophen-induced liver injury is attenuated in transgenic fat-1 mice endogenously synthesizing long-chain n-3 fatty acids

(2018) Ruibing Feng et al.   BIOCHEMICAL PHARMACOLOGY

Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis

(2018) Xia Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury

(2018) Ameng Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Daphnetin alleviates lipopolysaccharide/ d -galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-κB, and the induction of autophagy

(2018) Hongming Lv et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R–NLRP3-Inflammasome Activation

(2018) Yu Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation

(2018) Nadine Gehrke et al.   JOURNAL OF HEPATOLOGY

Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation

(2018) Shu Liu et al.   Food & Function

NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis

(2018) Jingyun Luan et al.   Frontiers in Immunology

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

Leucodin attenuates inflammatory response in macrophages and lipid accumulation in steatotic hepatocytes via P2x7 receptor pathway: A potential role in alcoholic liver disease

(2018) Yue Shang et al.   BIOMEDICINE & PHARMACOTHERAPY

Piceatannol attenuates D-GalN/LPS-induced hepatoxicity in mice: Involvement of ER stress, inflammation and oxidative stress

(2018) Jingjing Wen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis

(2018) Wei Sun et al.   Scientific Reports

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose

(2018) Alan Araujo et al.   Cells

n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review

(2018) Meng Wang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

DAMPs and sterile inflammation in drug hepatotoxicity

(2018) Runkuan Yang et al.   Hepatology International

Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver

(2018) Sabine Mihm   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of P2X7R–NLRP3 Inflammasome Activation by Pleurotus citrinopileatus: A Possible Protective Role in Alcoholic Hepatosteatosis

(2018) Xia Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis

(2018) Chongshan Dai et al.   Cell Death & Disease

Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-κB and Nrf2/NQO1 signalling pathways

(2018) Fayin Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Genipin protects d -galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling

(2017) Min-Jong Seo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis

(2017) Jelena Katanić et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy

(2017) Lulu Shen et al.   JOURNAL OF LIPID RESEARCH

NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury

(2017) Zhikai Xiahou et al.   Nature Communications

Protective mechanisms of wogonoside against Lipopolysaccharide/D-galactosamine-induced acute liver injury in mice

(2016) Yuan-zheng Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Chen-wei Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(2016) Peter Lundbäck et al.   HEPATOLOGY

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-κB, COX-2, and Pro-inflammatory Mediators

(2016) Naif O. Al-Harbi et al.   IMMUNOLOGICAL INVESTIGATIONS

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Xingkai Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation

(2016) Man Yang et al.   International Journal of Nanomedicine

Emerging role of HMGB1 in lung diseases: friend or foe

(2016) Junying Ding et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Paeoniflorin protects Schwann cells against high glucose induced oxidative injury by activating Nrf2/ARE pathway and inhibiting apoptosis

(2016) Xinwei Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Autophagy in macrophages regulates the inflammasome and protects against liver injury

(2016) Wen-Xing Ding et al.   JOURNAL OF HEPATOLOGY

The inflammasome in liver disease

(2016) Alexander Wree et al.   JOURNAL OF HEPATOLOGY

Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

(2016) Ghulam Ilyas et al.   JOURNAL OF HEPATOLOGY

Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation

(2016) JUN REN et al.   Molecular Medicine Reports

Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated cytokine production

(2016) Zhenxing He et al.   Molecular Medicine Reports

Acute systemic exposure to silver-based nanoparticles induces hepatotoxicity and NLRP3-dependent inflammation

(2016) Khalil B. Ramadi et al.   Nanotoxicology

Endogenous n-3 Fatty Acids Alleviate Carbon-Tetrachloride-Induced Acute Liver Injury in Fat-1 Transgenic Mice

(2016) Ruibing Feng et al.   Oxidative Medicine and Cellular Longevity

PGE2 induced in and released by dying cells functions as an inhibitory DAMP

(2016) Sho Hangai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

(2016) Anurag R. Mishra et al.   TOXICOLOGICAL SCIENCES

Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice

(2016) P K Barman et al.   Cell Death & Disease

Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway

(2016) Yan Zhuang et al.   PLoS One

Gut–Liver Axis in Alcoholic Liver Disease

(2015) Gyongyi Szabo   GASTROENTEROLOGY

Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway

(2015) Xiafei Wu et al.   IUBMB LIFE

Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice

(2015) Arvin Iracheta-Vellve et al.   JOURNAL OF HEPATOLOGY

Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice

(2015) Kele Cui et al.   JOURNAL OF HEPATOLOGY

Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease

(2015) Jan Petrasek et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury

(2015) M Deutsch et al.   Cell Death & Disease

Role of necroptosis in the pathogenesis of solid organ injury

(2015) H Zhao et al.   Cell Death & Disease

The inflammasome in alcoholic hepatitis: Its relationship with Mallory–Denk body formation

(2014) Yue Peng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice

(2014) Changchun Cai et al.   HEPATOLOGY

Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice

(2014) Pedro Elias Marques et al.   HEPATOLOGY

Understanding paracetamol-induced liver failure

(2014) Fin Stolze Larsen et al.   INTENSIVE CARE MEDICINE

Subendothelial resistin enhances monocyte transmigration in a co-culture of human endothelial and smooth muscle cells by mechanisms involving fractalkine, MCP-1 and activation of TLR4 and Gi/o proteins signaling

(2014) Monica Madalina Pirvulescu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway

(2014) Jia Xiao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Triptolide: Progress on research in pharmacodynamics and toxicology

(2014) Xiao-Jiaoyang Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism

(2014) Jia-qi Zhang et al.   Journal of Zhejiang University-SCIENCE B

Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle

(2014) Shuji Kojima et al.   TOXICOLOGY

Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity

(2013) Sylvia S Amaral et al.   Cell Communication and Signaling

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

NLRP3 inflammasome activation in d-galactosamine and lipopolysaccharide-induced acute liver failure: Role of heme oxygenase-1

(2013) Seok-Joo Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

(2013) David A. DeSantis et al.   MEDIATORS OF INFLAMMATION

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

(2012) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Therapeutic strategies in inflammasome mediated diseases of the liver

(2012) Rafaz Hoque et al.   JOURNAL OF HEPATOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Immune mechanisms of Concanavalin A model of autoimmune hepatitis

(2012) Hai-Xia Wang   WORLD JOURNAL OF GASTROENTEROLOGY

The role of LKB1 and AMPK in cellular responses to stress and damage

(2011) Angela Alexander et al.   FEBS LETTERS

Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury

(2011) Qiang Fu et al.   FITOTERAPIA

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

(2011) J. W. Dear et al.   JOURNAL OF IMMUNOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

(2011) Michal Ganz   WORLD JOURNAL OF GASTROENTEROLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Invasion pattern of Eupatorium adenophorum Spreng in southern China

(2009) Weiguo Sang et al.   BIOLOGICAL INVASIONS

Inflammasome and toll-like receptor 9: Partners in crime in toxic liver injury

(2009) Leif E. Sander et al.   HEPATOLOGY

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

Bacterial- and Viral-Induced Inflammation Increases Sensitivity to Acetaminophen Hepatotoxicity

(2009) Jane F. Maddox et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice

(2009) Brittany V. Martin-Murphy et al.   TOXICOLOGY LETTERS

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE