Receptors for pro-resolving mediators as a therapeutic tool for smooth muscle remodeling-associated disorders

Mechanisms, Evaluation, and Management of Chronic Constipation

(2020) Adil E. Bharucha et al.   GASTROENTEROLOGY

Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma

(2020) Lei Fang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Novel Small-molecule Annexin-A1 Mimetic, Compound 17b, Elicits Vasoprotective Actions in Streptozotocin-induced Diabetic Mice

(2020) Sarah A Marshall et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum resolvin D1 levels as a marker of inflammation in constipation dominant irritable bowel syndrome

(2020) Eylem Karatay et al.   Turkish Journal of Gastroenterology

Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells

(2020) Lin Chang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dual modulation of formyl peptide receptor 2 by aspirin‐triggered lipoxin contributes to its anti‐inflammatory activity

(2020) Yunjun Ge et al.   FASEB JOURNAL

Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up‐regulating alveolar ENaC, Na, K‐ATPase in lipopolysaccharide‐induced acute lung injury

(2020) Jun Han et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins

(2020) Sajad Chamani et al.   MEDIATORS OF INFLAMMATION

Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?

(2020) Keishi Miyazawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of Specialized Pro-Resolving Lipid Mediators in Autophagy and Inflammation

(2020) Antonio Recchiuti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Specialized pro-resolving mediators: It’s anti-oxidant stress role in multiple disease models

(2020) Fuquan Wang et al.   MOLECULAR IMMUNOLOGY

Resolvin E1 Improves Mitochondrial Function in Human Alveolar Epithelial Cells during Severe Inflammation

(2019) Konstantin Mayer et al.   LIPIDS

Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases

(2019) Shi Pan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Assessment of Crohn’s disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review

(2019) Dominik Bettenworth et al.   GUT

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Smooth Muscle Cell Phenotypic Diversity

(2019) Mingjun Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of lung immunity by dendritic cells: Implications for asthma, chronic obstructive pulmonary disease and infectious disease

(2019) Marcus Peters et al.   Innate Immunity

Chemotactic Ligands that Activate G-Protein-Coupled Formylpeptide Receptors

(2019) Stacey A Krepel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intestinal Macrophages in Resolving Inflammation

(2019) Ashley M. Hine et al.   JOURNAL OF IMMUNOLOGY

Targeting immune cell circuits and trafficking in inflammatory bowel disease

(2019) Markus F. Neurath   NATURE IMMUNOLOGY

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Innate Lymphoid Cells in Mucosal Immunity

(2019) Santosh K. Panda et al.   Frontiers in Immunology

Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity

(2019) Desheng Hu et al.   Frontiers in Immunology

Organ/Tissue-Specific Vascular Endothelial Cell Heterogeneity in Health and Disease

(2019) Takashi Minami et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Apolipoprotein A-I mimetics mitigate intestinal inflammation in a COX2-dependent inflammatory disease model

(2019) David Meriwether et al.   JOURNAL OF CLINICAL INVESTIGATION

Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment

(2019) Luísa Leite Barros et al.   WORLD JOURNAL OF GASTROENTEROLOGY

N-3 Polyunsaturated Fatty Acids and the Resolution of Neuroinflammation

(2019) Corinne Joffre et al.   Frontiers in Pharmacology

Enteric neuroplasticity and dysmotility in inflammatory disease: key players and possible therapeutic targets

(2019) Estelle T. Spear et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology.

(2019) Ewa Trojan et al.   Current Neuropharmacology

The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes

(2019) Armand Jaminon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes

(2019) Bruce D. Levy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

European society of neurogastroenterology and motility guidelines on functional constipation in adults

(2019) Jordi Serra et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

(2019) Paraskevi Krashia et al.   Nature Communications

Phosphoproteomic analysis sheds light on intracellular signaling cascades triggered by Formyl-Peptide Receptor 2

(2019) Fabio Cattaneo et al.   Scientific Reports

Immune and Smooth Muscle Cells Interactions in Atherosclerosis: How to Target a Breaking Bad Dialogue?

(2019) Damien Ramel et al.   Frontiers in Pharmacology

Dysbiosis-Associated Enteric Glial Cell Immune-Activation and Redox Imbalance Modulate Tight Junction Protein Expression in Gulf War Illness Pathology

(2019) Diana Kimono et al.   Frontiers in Physiology

Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

(2019) Gregory Livshits et al.   AGEING RESEARCH REVIEWS

Smooth Muscle Cells in Vascular Remodeling

(2019) Ning Shi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Immune induction of airway remodeling

(2019) Giuseppe Guida et al.   SEMINARS IN IMMUNOLOGY

Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells

(2019) Nathalie Stakenborg et al.   CURRENT OPINION IN NEUROBIOLOGY

Smooth muscle cell fate and plasticity in atherosclerosis

(2018) Sima Allahverdian et al.   CARDIOVASCULAR RESEARCH

Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension

(2018) Kurt R Stenmark et al.   CARDIOVASCULAR RESEARCH

ERV1/ChemR23 Signaling Protects from Atherosclerosis by Modifying oxLDL Uptake and Phagocytosis in Macrophages

(2018) Andres Laguna-Fernandez et al.   CIRCULATION

Role of neutrophils in allergic asthma

(2018) Coraline Radermecker et al.   CURRENT OPINION IN IMMUNOLOGY

Airway remodeling in asthma

(2018) Louis-Philippe Boulet   CURRENT OPINION IN PULMONARY MEDICINE

Targeting formyl peptide receptors to facilitate the resolution of inflammation

(2018) János G. Filep et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biological therapies for eosinophilic asthma

(2018) Shiven S. Patel et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Systematic review and comparison of national and international guidelines on diverticular disease

(2018) T. Galetin et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Pathophysiology, Diagnosis, and Management of Chronic Intestinal Pseudo-Obstruction

(2018) Thomas J. Downes et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Asthma

(2018) Alberto Papi et al.   LANCET

Hierarchical, imbalanced pro-inflammatory cytokine networks govern the pathogenesis of chronic arthropathies

(2018) G. Livshits et al.   OSTEOARTHRITIS AND CARTILAGE

What is the role of endogenous gut serotonin in the control of gastrointestinal motility?

(2018) Damien J. Keating et al.   PHARMACOLOGICAL RESEARCH

Towards targeting resolution pathways of airway inflammation in asthma

(2018) Cindy Barnig et al.   PHARMACOLOGY & THERAPEUTICS

Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases

(2018) Nandini Krishnamoorthy et al.   PHYSIOLOGICAL REVIEWS

The roles of special proresolving mediators in pain relief

(2018) Lan-yu Zhang et al.   REVIEWS IN THE NEUROSCIENCES

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

(2018) Maria Angela Incalza et al.   VASCULAR PHARMACOLOGY

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

(2018) Valerio Chiurchiù et al.   Frontiers in Immunology

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

(2018) Isola A.M. Brown et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

(2018) Agne Frismantiene et al.   CELLULAR SIGNALLING

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuronal regulation of intestinal immune functions in health and disease

(2018) M. Fornai et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The anti-inflammatory effect of BML-111 on COPD may be mediated by regulating NLRP3 inflammasome activation and ROS production

(2018) Yuan Cao et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

(2018) Elisabeth Weiß et al.   TRENDS IN IMMUNOLOGY

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

(2018) Georg Schett et al.   Nature Communications

The G-protein coupled receptor ChemR23 determines smooth muscle cell phenotypic switching to enhance high phosphate-induced vascular calcification

(2018) Miguel Carracedo et al.   CARDIOVASCULAR RESEARCH

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Proresolving Lipid Mediators Resolvin D1 and Protectin D1 Isomer Attenuate Neointimal Hyperplasia in the Rat Carotid Artery Balloon Injury Model

(2018) Yoshihisa Makino et al.   JOURNAL OF SURGICAL RESEARCH

Resolvin D1 decreases abdominal aortic aneurysm formation by inhibiting NETosis in a mouse model

(2018) Michael Spinosa et al.   JOURNAL OF VASCULAR SURGERY

Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications

(2018) Monica de Gaetano et al.   Frontiers in Pharmacology

Role of inflammatory cells in airway remodeling in COPD

(2018) Yujie Wang et al.   International Journal of Chronic Obstructive Pulmonary Disease

Biased perspectives on formyl peptide receptors

(2018) Carsten Alexander Raabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function

(2018) Sabine Schneider et al.   Annual Review of Physiology

AT-RvD1 modulates the activation of bronchial epithelial cells induced by lipopolysaccharide and Dermatophagoides pteronyssinus

(2017) Jhony Robison de Oliveira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing

(2017) Jeff Chang et al.   GASTROENTEROLOGY

Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease

(2017) Calogera Pisano et al.   MEDIATORS OF INFLAMMATION

Specialized pro-resolving mediators in cardiovascular diseases

(2017) Gabrielle Fredman et al.   MOLECULAR ASPECTS OF MEDICINE

Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation

(2017) Melody G. Duvall et al.   MOLECULAR ASPECTS OF MEDICINE

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease

(2017) Patrick Lacolley et al.   PHYSIOLOGICAL REVIEWS

Protectin D1n-3 DPAand resolvin D5n-3 DPAare effectors of intestinal protection

(2017) Thomas Gobbetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating inflammation-resolving lipid mediators RvD1 and DHA are decreased in patients with acutely symptomatic carotid disease

(2017) Hernan A. Bazan et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

(2017) Cheng Xue Qin et al.   Nature Communications

Are specialized pro-resolving mediators promising therapeutic agents for severe bronchial asthma?

(2017) Takeshi Hisada et al.   Journal of Thoracic Disease

Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease

(2016) Y. S. Prakash   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Biased agonism: An emerging paradigm in GPCR drug discovery

(2016) Zoran Rankovic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Mast cells in asthma - state of the art

(2016) P. Bradding et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

(2016) Tarec K. Elajami et al.   FASEB JOURNAL

Clearance of apoptotic neutrophils and resolution of inflammation

(2016) Mallary C. Greenlee-Wacker   IMMUNOLOGICAL REVIEWS

Maresin 1 Maintains the Permeability of Lung Epithelial Cells In Vitro and In Vivo

(2016) Lin Chen et al.   INFLAMMATION

Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype

(2016) Andromeda Liñán-Rico et al.   INFLAMMATORY BOWEL DISEASES

Increased expression of phosphorylated forms of heat-shock protein-27 and p38MAPK in macrophage-rich regions of fibro-fatty atherosclerotic lesions in the rabbit

(2016) Shahida Shafi et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Airway lipoxin A 4 /formyl peptide receptor 2–lipoxin receptor levels in pediatric patients with severe asthma

(2016) Rosalia Gagliardo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fibrotic and Vascular Remodelling of Colonic Wall in Patients with Active Ulcerative Colitis

(2016) Chiara Ippolito et al.   Journal of Crohns & Colitis

Inflammatory bowel disease as a disorder of an imbalance between pro- and anti-inflammatory molecules and deficiency of resolution bioactive lipids

(2016) Undurti N. Das   Lipids in Health and Disease

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

Vascular smooth muscle cell in atherosclerosis

(2015) D. A. Chistiakov et al.   Acta Physiologica

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

(2015) Sarah K. Orr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

(2015) H. Hasturk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Biomarkers of Inflammation in Inflammatory Bowel Disease

(2015) Bruce E. Sands   GASTROENTEROLOGY

Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation

(2015) Marcelo H. Petri et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4

(2015) Jhony Robison de Oliveira et al.   Biomed Research International

Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases

(2015) Jun Miyata et al.   ALLERGOLOGY INTERNATIONAL

Protective Actions of Aspirin-Triggered (17R) Resolvin D1 and Its Analogue, 17R-Hydroxy-19-Para-Fluorophenoxy-Resolvin D1 Methyl Ester, in C5a-Dependent IgG Immune Complex–Induced Inflammation and Lung Injury

(2014) Huifang Tang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of Lung Inflammation

(2014) Nandini Krishnamoorthy et al.   JOURNAL OF IMMUNOLOGY

The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells

(2014) Anuran Chatterjee et al.   PLoS One

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Airway smooth muscle in the pathophysiology and treatment of asthma

(2013) Diana C. Doeing et al.   JOURNAL OF APPLIED PHYSIOLOGY

Maresin 1, a Proresolving Lipid Mediator Derived from Omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis

(2013) R. Marcon et al.   JOURNAL OF IMMUNOLOGY

Bronchial Smooth Muscle Cells of Asthmatics Promote Angiogenesis through Elevated Secretion of CXC-Chemokines (ENA-78, GRO-α, and IL-8)

(2013) Laura Keglowich et al.   PLoS One

Novel Anti-Inflammatory-Pro-Resolving Mediators and Their Receptors

(2012) Charles N. Serhan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Phenotype modulation of airway smooth muscle in asthma

(2012) David B. Wright et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Resolution of inflammation in obesity-induced liver disease

(2012) Bibiana Rius et al.   Frontiers in Immunology

Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury

(2011) Min He et al.   ACTA PHARMACOLOGICA SINICA

Perivascular adipose tissue: more than just structural support

(2011) Theodora Szasz et al.   CLINICAL SCIENCE

Airway smooth muscle and immunomodulation in acute exacerbations of airway disease

(2011) Cynthia J. Koziol-White et al.   IMMUNOLOGICAL REVIEWS

Omega-3 Fatty Acid-Derived Mediators 17(R)-Hydroxy Docosahexaenoic Acid, Aspirin-Triggered Resolvin D1 and Resolvin D2 Prevent Experimental Colitis in Mice

(2011) A. F. Bento et al.   JOURNAL OF IMMUNOLOGY

Aspirin-Triggered Lipoxin and Resolvin E1 Modulate Vascular Smooth Muscle Phenotype and Correlate with Peripheral Atherosclerosis

(2010) Karen J. Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Protective effect of resolvin E1 on the development of asthmatic airway inflammation

(2010) Haruka Aoki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium–induced colitis

(2009) Tsukasa Ishida et al.   INFLAMMATORY BOWEL DISEASES

Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties

(2008) Nicos A. Petasis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

(2008) Oliver Haworth et al.   NATURE IMMUNOLOGY