Airway smooth muscle in the pathophysiology and treatment of asthma

Human Airway Smooth Muscle Promotes Human Lung Mast Cell Survival, Proliferation, and Constitutive Activation: Cooperative Roles for CADM1, Stem Cell Factor, and IL-6

(2014) F. Hollins et al.   JOURNAL OF IMMUNOLOGY

Dilatation of the Constricted Human Airway by Tidal Expansion of Lung Parenchyma

(2012) Tera L. Lavoie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma

(2012) Alan L. James et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Monoclonal antibodies for chronic refractory asthma and pipeline developments

(2012) Riccardo Polosa et al.   DRUG DISCOVERY TODAY

Use of continuous positive airway pressure reduces airway reactivity in adults with asthma

(2012) Michael Busk et al.   EUROPEAN RESPIRATORY JOURNAL

A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation

(2012) Xiaofeng Jiang et al.   FASEB JOURNAL

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells

(2012) Kotaro Sugimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle

(2011) Lan Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype

(2011) Paul-André Risse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Bronchial Thermoplasty for Severe Asthma

(2011) Momen M. Wahidi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor

(2011) N. A. Molfino et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Insights into the initiation of type 2 immune responses

(2011) Chris J. Oliphant et al.   IMMUNOLOGY

Remodeling in asthma

(2011) Saleh Al-Muhsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic continuous positive airway pressure (CPAP) reduces airway reactivity in vivo in an allergen-induced rabbit model of asthma

(2011) Z. Xue et al.   JOURNAL OF APPLIED PHYSIOLOGY

Biochemical Basis of Asthma Therapy

(2011) Peter J. Barnes   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin  v 5-Mediated TGF-  Activation by Airway Smooth Muscle Cells in Asthma

(2011) A. L. Tatler et al.   JOURNAL OF IMMUNOLOGY

Effect of Bronchoconstriction on Airway Remodeling in Asthma

(2011) Christopher L. Grainge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relationship between polymorphisms in the 5′ leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China

(2011) WEI-PING FU et al.   RESPIROLOGY

Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6

(2010) P.-O. Girodet et al.   ALLERGY

An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure

(2010) Connie C. W. Hsia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

T Cells Localize with Proliferating Smooth Muscle α-Actin+Cell Compartments in Asthma

(2010) David Ramos-Barbón et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acute Response of Airway Muscle to Extreme Temperature Includes Disruption of Actin–Myosin Interaction

(2010) Peter Dyrda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bronchial Hyperresponsiveness in the Assessment of Asthma Control

(2010) John D. Brannan   CHEST

Recent Advances in the Pathophysiology of Asthma

(2010) Desmond M. Murphy et al.   CHEST

The multiple dimensions of airways disease: targeting treatment to clinical phenotypes

(2010) Philippa Shirtcliffe et al.   CURRENT OPINION IN PULMONARY MEDICINE

MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle

(2010) M. L. Dowell et al.   EUROPEAN RESPIRATORY JOURNAL

The role of the T cell in asthma

(2010) Douglas S. Robinson   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma

(2010) Muhannad Hassan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Emergence of airway smooth muscle functions related to structural malleability

(2010) Chun Y. Seow et al.   JOURNAL OF APPLIED PHYSIOLOGY

RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma

(2010) Yoshihiko Chiba et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Receptor-Mediated Enhancement of Beta Adrenergic Drug Activity by Ascorbate In Vitro and In Vivo

(2010) Patrick F. Dillon et al.   PLoS One

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma

(2009) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chronic Activation in Shortened Airway Smooth Muscle

(2009) Ynuk Bossé et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

p70 Ribosomal S6 Kinase Is Required for Airway Smooth Muscle Cell Size Enlargement but Not Increased Contractile Protein Expression

(2009) Huan Deng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Airway smooth muscle thickness in asthma is related to severity but not duration of asthma

(2009) A. L. James et al.   EUROPEAN RESPIRATORY JOURNAL

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation

(2008) Dedmer Schaafsma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Increased Airway Smooth Muscle Mass in Children with Asthma, Cystic Fibrosis, and Non-Cystic Fibrosis Bronchiectasis

(2008) Nicolas Regamey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased Circulating Fibrocytes in Asthma with Chronic Airflow Obstruction

(2008) Chun-Hua Wang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Daclizumab Improves Asthma Control in Patients with Moderate to Severe Persistent Asthma

(2008) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Airway Inflammation in Asthma

(2008) Nicola A. Hanania   CHEST

Rho kinase inhibitors: A novel therapeutical intervention in asthma?

(2008) Dedmer Schaafsma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma

(2008) O. J. Lakser et al.   EUROPEAN RESPIRATORY JOURNAL

Fibrocyte localization to the airway smooth muscle is a feature of asthma

(2008) Ruth Saunders et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway smooth muscle as an immunomodulatory cell

(2008) Gautam Damera et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Chronic inflation of ferret lungs with CPAP reduces airway smooth muscle contractility in vivo and in vitro

(2007) Z. Xue et al.   JOURNAL OF APPLIED PHYSIOLOGY