Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells

Notch signaling in bone marrow–derived FSP-1 cells initiates neointima formation in arteriovenous fistulas

(2019) Ming Liang et al.   KIDNEY INTERNATIONAL

Adipose-derived stem cell extracellular vesicles: a systematic review

(2019) Daniel E. Wong et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Perivascular adipose tissue‐derived stromal cells contribute to vascular remodeling during aging

(2019) Xiao‐Xi Pan et al.   AGING CELL

Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling

(2019) Wenduo Gu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adventitial Cell Atlas of wt (Wild Type) and ApoE (Apolipoprotein E)-Deficient Mice Defined by Single-Cell RNA Sequencing

(2019) Wenduo Gu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired function of aorta and perivascular adipose tissue in IL-18-deficient mice

(2019) Wen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neural Crest Cells Differentiate Into Brown Adipocytes and Contribute to Periaortic Arch Adipose Tissue Formation

(2019) Mengxia Fu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Perivascular adipose tissue–derived extracellular vesicle miR-221-3p mediates vascular remodeling

(2019) Xinzhi Li et al.   FASEB JOURNAL

Perivascular adipose tissue contributes to lethal sepsis-induced vasoplegia in rats

(2019) Wanessa M.C. Awata et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Perivascular adipose tissue modulation of neurogenic vasorelaxation of rat mesenteric arteries

(2019) Hsi-Hsien Chang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulphide and cystathionine-β-synthase

(2018) J. Donovan et al.   Acta Physiologica

Role of Sympathetic Nerves and Adipocyte Catecholamine Uptake in the Vasorelaxant Function of Perivascular Adipose TissueHighlights

(2018) Sophie N. Saxton et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MitoNEET in Perivascular Adipose Tissue Prevents Arterial Stiffness in Aging Mice

(2018) Lin Chang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen

(2018) Lin Chang et al.   CIRCULATION

Noctural dipping status and left ventricular hypertrophy: A cardiac magnetic resonance imaging study

(2018) Jonathan C. L. Rodrigues et al.   Journal of Clinical Hypertension

Depletion of dendritic cells in perivascular adipose tissue improves arterial relaxation responses in type 2 diabetic mice

(2018) Tianyi Qiu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Physiologic levels of resistin induce a shift from proliferation to apoptosis in macrophage and VSMC co-culture

(2018) Mary C. Zuniga et al.   SURGERY

Renal perivascular adipose tissue: Form and function

(2018) Carolina Baraldi A. Restini et al.   VASCULAR PHARMACOLOGY

The differentiation of mesenchymal stem cells to vascular cells regulated by the HMGB1/RAGE axis: its application in cell therapy for transplant arteriosclerosis

(2018) Xiaohu Meng et al.   Stem Cell Research & Therapy

Palmitic Acid Methyl Ester and Its Relation to Control of Tone of Human Visceral Arteries and Rat Aortas by Perivascular Adipose Tissue

(2018) Ning Wang et al.   Frontiers in Physiology

High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion

(2018) Tarek A. M. Almabrouk et al.   Frontiers in Physiology

PVAT and Its Relation to Brown, Beige, and White Adipose Tissue in Development and Function

(2018) Staffan Hildebrand et al.   Frontiers in Physiology

Rab27a Regulates Human Perivascular Adipose Progenitor Cell Differentiation

(2018) Joshua M. Boucher et al.   CARDIOVASCULAR DRUGS AND THERAPY

miR-143 and miR-145 promote hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells through regulating ABCA1 expression

(2018) Yuxia Yue et al.   CARDIOVASCULAR PATHOLOGY

The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm

(2018) Jichong Xu et al.   GENE

Genetic lineage tracing analysis of c-kit+ stem/progenitor cells revealed a contribution to vascular injury-induced neointimal lesions

(2018) Qishan Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fenfluramine-induced PVAT-dependent contraction depends on norepinephrine and not serotonin

(2018) Ramya K. Kumar et al.   PHARMACOLOGICAL RESEARCH

Developmental and functional characteristics of the thoracic aorta perivascular adipocyte

(2018) Maoqing Ye et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting white, brown and perivascular adipose tissue in atherosclerosis development

(2017) Andrea D. van Dam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased coronary heart disease and stroke hospitalisations from ambient temperatures in Ontario

(2017) Li Bai et al.   HEART

‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk

(2017) Peter Aldiss et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The mechanism of action and role of hydrogen sulfide in the control of vascular tone

(2017) Eleni Dongó et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft

(2017) Ekene Onwuka et al.   Regenerative Medicine

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality

(2017) Sarah B. Withers et al.   Scientific Reports

Perivascular Adipose Tissue's Impact on Norepinephrine-Induced Contraction of Mesenteric Resistance Arteries

(2017) Nadia Ayala-Lopez et al.   Frontiers in Physiology

MitoNEET in Perivascular Adipose Tissue Blunts Atherosclerosis under Mild Cold Condition in Mice

(2017) Wenhao Xiong et al.   Frontiers in Physiology

Contribution of Vascular Cells to Neointimal Formation

(2017) Falei Yuan et al.   PLoS One

The adipokine chemerin amplifies electrical field-stimulated contraction in the isolated rat superior mesenteric artery

(2016) Emma S. Darios et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PKCε mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia

(2016) Gayatri Raghuraman et al.   ATHEROSCLEROSIS

Do KV7.1 channels contribute to control of arterial vascular tone?

(2016) Dmitry Tsvetkov et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk

(2016) Xiaoming Lian et al.   CURRENT HYPERTENSION REPORTS

Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II–Dependent Hypertension in Mice

(2016) Paramita Pati et al.   HYPERTENSION

Loss of anti-contractile effect of perivascular adipose tissue in offspring of obese rats

(2016) K E Zaborska et al.   INTERNATIONAL JOURNAL OF OBESITY

Endothelial-like cells differentiated from mesenchymal stem cells attenuate neointimal hyperplasia after vascular injury

(2016) Jianzhong Xu et al.   Molecular Medicine Reports

H 2 O 2 generated from mitochondrial electron transport chain in thoracic perivascular adipose tissue is crucial for modulation of vascular smooth muscle contraction

(2016) Rafael M. Costa et al.   VASCULAR PHARMACOLOGY

The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of Vascular Tone

(2016) Dmitry Tsvetkov et al.   Frontiers in Physiology

Different Anti-Contractile Function and Nitric Oxide Production of Thoracic and Abdominal Perivascular Adipose Tissues

(2016) Jamaira A. Victorio et al.   Frontiers in Physiology

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese MiceSignificance

(2015) Ning Xia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hydrogen-sulfide-mediated vasodilatory effect of nucleoside 5′-monophosphorothioates in perivascular adipose tissue

(2015) Jerzy Bełtowski et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure

(2015) Reza Aghamohammadzadeh et al.   JOURNAL OF VASCULAR RESEARCH

Perivascular Adipose Tissue in Vascular Function and Disease

(2014) Nicholas K. Brown et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth muscle cells from the anastomosed artery are the major precursors for neointima formation in both artery and vein grafts

(2014) Ming Liang et al.   BASIC RESEARCH IN CARDIOLOGY

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells

(2014) Dorothea I. Siegel-Axel et al.   DIABETOLOGIA

Perivascular adipose tissue-derived leptin promotes vascular smooth muscle cell phenotypic switching via p38 mitogen-activated protein kinase in metabolic syndrome rats

(2014) Hao Li et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation

(2014) Zhongwen Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Imbalance between Pro and Anti-Oxidant Mechanisms in Perivascular Adipose Tissue Aggravates Long-Term High-Fat Diet-Derived Endothelial Dysfunction

(2014) Marta Gil-Ortega et al.   PLoS One

Perivascular Adipose Tissue Inhibits Endothelial Function of Rat Aortas via Caveolin-1

(2014) Michelle Hui-Hsin Lee et al.   PLoS One

Perivascular adipose tissue-derived adiponectin activates BKCa channels to induce anticontractile responses

(2013) Fiona M. Lynch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues

(2013) Jaume Padilla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Chemerin Connects Fat to Arterial Contraction

(2013) Stephanie W. Watts et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rictor in Perivascular Adipose Tissue Controls Vascular Function by Regulating Inflammatory Molecule Expression

(2013) Indranil Bhattacharya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leptin-Dependent and Leptin-Independent Paracrine Effects of Perivascular Adipose Tissue on Neointima Formation

(2013) Marco R. Schroeter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCachannels and adiponectin

(2013) A H Weston et al.   BRITISH JOURNAL OF PHARMACOLOGY

cGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue

(2013) Sarah B. Withers et al.   CARDIOVASCULAR RESEARCH

Perivascular Adipose Tissue Potentiates Contraction of Coronary Vascular Smooth Muscle

(2013) Meredith Kohr Owen et al.   CIRCULATION

C-reactive protein promotes vascular endothelial dysfunction partly via activating adipose tissue inflammation in hyperlipidemic rabbits

(2013) YangXin Chen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effect of high free fatty acids on the anti-contractile response of perivascular adipose tissue in rat aorta

(2013) Xiaodong Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Resistin derived from diabetic perivascular adipose tissue up-regulates vascular expression of osteopontin via the AP-1 signalling pathway

(2013) So Youn Park et al.   JOURNAL OF PATHOLOGY

Tumor Necrosis Factor-a Induces Aortic Intima-Media Thickening via Perivascular Adipose Tissue Inflammation

(2013) Kyaw Thu Moe et al.   JOURNAL OF VASCULAR RESEARCH

VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells: Depot-Specific Release from Visceral and Perivascular Adipose Tissue

(2013) Raphaela Schlich et al.   MEDIATORS OF INFLAMMATION

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of human vascular tone by prostanoids derived from perivascular adipose tissue

(2013) Gulsev Ozen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis

(2012) Lin Chang et al.   CIRCULATION

The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells

(2012) K. Rittig et al.   DIABETOLOGIA

Reduced anti-contractile effect of perivascular adipose tissue on mesenteric small arteries from spontaneously hypertensive rats: Role of Kv7 channels

(2012) Rui Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation

(2012) Yusuke Uemura et al.   FASEB JOURNAL

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells

(2012) Sindura B. Ganapathi et al.   HYPERTENSION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Exacerbates Obesity-Induced Oxidative Stress and Inflammation in Perivascular Adipose Tissue in Mice: A Paracrine Mechanism Contributing to Vascular Redox Dysregulation and Inflammation

(2012) L. C. Bailey-Downs et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Differential Effects of Cystathionine-γ-lyase–Dependent Vasodilatory H2S in Periadventitial Vasoregulation of Rat and Mouse Aortas

(2012) Carolin Köhn et al.   PLoS One

Differentiation of multipotent vascular stem cells contributes to vascular diseases

(2012) Zhenyu Tang et al.   Nature Communications

Anticontractile Effect of Perivascular Adipose Tissue and Leptin are Reduced in Hypertension

(2012) Beatriz Gálvez-Prieto et al.   Frontiers in Pharmacology

Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation

(2011) Timothy P. Fitzgibbons et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells

(2011) Qinxue Ding et al.   JOURNAL OF VASCULAR SURGERY

Baseline severity but not gender modulates quantified Crataegus extract effects in early heart failure – A pooled analysis of clinical trials

(2011) Thomas Eggeling et al.   PHYTOMEDICINE

Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via Oxidative Stress in Diet-Induced Obese C57Bl/6 Mice

(2010) Juha Ketonen et al.   CIRCULATION JOURNAL

Crosstalk between perivascular adipose tissue and blood vessels

(2010) Srinivas Rajsheker et al.   CURRENT OPINION IN PHARMACOLOGY

Adaptative Nitric Oxide Overproduction in Perivascular Adipose Tissue during Early Diet-Induced Obesity

(2010) Marta Gil-Ortega et al.   ENDOCRINOLOGY

Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: The role of adipocyte-derived angiotensin II

(2010) Chao Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats

(2010) Liqun Ma et al.   HYPERTENSION RESEARCH

Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin

(2009) Changtao Jiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Vascular Smooth Muscle Cell–Selective Peroxisome Proliferator–Activated Receptor-γ Deletion Leads to Hypotension

(2009) Lin Chang et al.   CIRCULATION

Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling

(2009) Minoru Takaoka et al.   CIRCULATION RESEARCH

The Functional Changes of the Perivascular Adipose Tissue in Spontaneously Hypertensive Rats and the Effects of Atorvastatin Therapy

(2009) Zhao-Hua Zeng et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Endothelium-dependent relaxation factor released by perivascular adipose tissue

(2009) Robert MKW Lee et al.   JOURNAL OF HYPERTENSION

Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide

(2008) Pei Wang et al.   CARDIOVASCULAR RESEARCH

Vascular PPARγ Controls Circadian Variation in Blood Pressure and Heart Rate through Bmal1

(2008) Ningning Wang et al.   Cell Metabolism

Interference with PPARγ Function in Smooth Muscle Causes Vascular Dysfunction and Hypertension

(2008) Carmen M. Halabi et al.   Cell Metabolism

Causes and Mechanisms of Nondipping Hypertension

(2008) Mehmet Kanbay et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin

(2008) G. William Wong et al.   FASEB JOURNAL

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE